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Kindlin Antibody (710862) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized A-431 cells for detection of Kindlin1 using Kindlin1 Recombinant Rabbit Superclonal™ Antibody (Product # 710862, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Kindlin1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Pa... View More
产品信息
710862
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Protein corresponding to Human FERMT1 (aa 200-409).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Cat, Dog and Horse.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fermitin family homolog 1; FLJ20116; FLJ23423; Kindlerin; kindlin 1; Kindlin syndrome protein; Kindlin-1; RP5-1056H1.1; Unc-112-related protein 1; UNC112 related protein 1
基因别名: C20orf42; DTGCU2; FERMT1; KIND1; UNC112A; URP1
UniProt ID: (Human) Q9BQL6
Entrez Gene ID: (Human) 55612
