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Proteintech
LRRFIP1 Polyclonal Antibody
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产品信息
31186-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LRRFIP1 fusion protein Ag34760
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: EEEGEETGLR DEKPIKTEVP GSPAGTEGNC QEATGPSTVD TQNEPLDMKE PDEEKSDQQG EAFDSSQKKT KNKKKKNKKK KSPVPVETLK DVKKELTYQN TDLSEIKEEE QVKSTDRKSA VEAQNEVTEN PKQKIAAESS ENVDCPENPK IKLDGKLDQE GDDVQTAAEE VLADGDTLDF EDDTVQSSGP RAGGEELDEG VAKDNAKIDG ATQSSPAEPK SEDADRCTLP EHESPSQDIS DACEAESTER CEMSEHPSQT VRKALDSNSL ENDDLSAPGR EPGHFNPESR EDTRGGNEKG KSKEDCTMS
靶标信息
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity. Flap-1 or LRRFIP1 was also shown to bind the TNF- -308 promoter polymorphism site, suggesting its possible role in the regulation of TNF- production. FLAP-1 along with LRRFIP2 and FLIIH serve as a balance in coordinating inflammatory response after infection, and may act as a novel target in the control of agonist-induced TLR-mediated inflammatory and autoimmune diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GC-binding factor 2; HUFI1; leucine rich repeat (in FLII) interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; NEDD8-conjugating enzyme; TAR RNA-interacting protein
基因别名: FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; LRRFIP1; TRIP
UniProt ID: (Human) Q32MZ4
Entrez Gene ID: (Human) 9208
