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Invitrogen
LYK5 Polyclonal Antibody
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产品信息
PA5-87821
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_6991662)
偶联物
形式
Liquid
浓度
1.98 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FLPEGGCYEL LTVIGKGFED LMTVNLARYK PTGEYVTVRR INLEACSNEM VTFLQGELHV SKLFNHPNIV PYRATFIADN ELWVVTSFMA YGSAKDLICT HFMDGMNELA IAYILQGVLK ALDYIHHMGY VHRSVKASHI LISVDGKVYL SGLRSNLSMI SHGQRQRVVH DFPKYSVKVL PWLSPE; Positive Samples: Mouse skeletal muscle; Cellular Location: Cytoplasm, Nucleus
靶标信息
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protein kinase LYK5; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
基因别名: 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; Lyk5; Strad; Strada
UniProt ID: (Mouse) Q3UUJ4
Entrez Gene ID: (Mouse) 72149
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
transferase activity, transferring phosphorus-containing groups
kinase binding
protein kinase activator activity
protein serine/threonine kinase activator activity
non-receptor serine/threonine protein kinase
protein phosphorylation
protein export from nucleus
cell cycle
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
regulation of MAPK cascade
protein heterooligomerization
positive regulation of protein serine/threonine kinase activity
