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Immunogen sequence: QLKESQTEV NAKASEILGL KAQLKDTRGK LEGLELRTQD LEGALRTKGL ELEVCENELQ RKKNEAELLR EKVNLLEQEL QELRAQAALA RDMGPPTFPE DVPALQRELE RLRAELREER QGHDQMSSGF QHERLVWKEE KEKVIQYQKQ LQQSYVAMYQ RNQRLEKALQ QLARGDSAGE PLEVDLEGAD IPYEDIIATE I (397-596 aa encoded by BC075007)
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: F37 esophageal cancer-related leucine zipper motif 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; Fez1; Leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1; leucine-zipper protein FEZ1; PSD-Zip70
基因别名: F37; FEZ1; LZTS1; Psdzip70
UniProt ID: (Human) Q9Y250, (Mouse) P60853, (Rat) Q8CFC9
Entrez Gene ID: (Human) 11178, (Mouse) 211134, (Rat) 266711