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MARCKS Antibody (PA5-143575) in ICC/IF
Immunofluorescent analysis of MARCKS in HeLa cells. Samples were stained with MARCKS polyclonal antibody (Product # PA5-143575) using a dilution of 1:5,000 (red). Costained with mouse mAb to beta tubulin (Product # MA5-47383) dilution 1:10,000 in green. The blue is Hoechst staining of nuclear DNA. The MARKS antibody binds to MARCKS protein expressed in the plasma membrane and cytoplasm, while the beta tubulin antibody stains cytoplasmic microtubules.
产品信息
PA5-143575
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Full length recombinant human MARCKS expressed in and purified from E. coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
PBS
内含物
5mM sodium azide
保存条件
4° C
运输条件
Wet ice
RRID
AB_2942804
靶标信息
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 80K-L protein; FLJ14368; FLJ90045; MARCKS; MARCS; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; Protein kinase C substrate, 80 kDa protein, light chain
基因别名: 80K-L; MACS; MARCKS; PKCSL; PRKCSL
UniProt ID: (Human) Q2LA83
Entrez Gene ID: (Human) 4082
ventricular cardiac muscle tissue development
intracellular protein transport
actin filament organization
brain development
activation of phospholipase D activity
cell-substrate adhesion
regulation of insulin secretion
positive regulation of dendritic spine morphogenesis
positive regulation of protein kinase C activity
positive regulation of glucose import in response to insulin stimulus
