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Invitrogen
MPZL1 Polyclonal Antibody
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MPZL1 Antibody (PA5-88952) in WB
Western blot analysis of MPZL1 in extracts of various cell lines. Samples were incubated with MPZL1 Polyclonal antibody (Product # PA5-88952) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-88952
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 195-269 of human MPZL1 (NP_0039441)
偶联物
形式
Liquid
浓度
1.95 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NSKRDYTGCS TSESLSPVKQ APRKSPSDTE GLVKSLPSGS HQGPVIYAQL DHSGGHHSDK INKSESVVYA DIRKN
Positive Samples: BxPC-3, HeLa, Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein
靶标信息
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ21047; immunoglobulin family transmembrane protein; myelin protein zero-like 1; Myelin protein zero-like protein 1; protein zero related; Protein zero-related
基因别名: 1110007A10Rik; MPZL1; MPZL1b; PZR; PZR1b; PZRa; PZRb; UNQ849/PRO1787
UniProt ID: (Human) O95297, (Rat) Q6AYT8, (Mouse) Q3TEW6
Entrez Gene ID: (Human) 9019, (Rat) 360871, (Mouse) 68481
