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Invitrogen
MSX2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78064
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human MSX2. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: HL-60, 293T, A431, HeLa, HepG2, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12
Predicted Reactivity: Rat (86%), Dog (86%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box, msh-like 2; homeobox protein; homeobox protein Hox-8; homeobox protein Hox-8-1; homeobox, msh-like 2; msh homeo box 2; msh homeobox homolog 2; unnamed protein product
基因别名: CRS2; FPP; Hox-8; HOX8; Hox8.1; MSH; PFM; PFM1
UniProt ID: (Human) P35548, (Mouse) Q03358
Entrez Gene ID: (Human) 4488, (Mouse) 17702
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
cardiac conduction system development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
organ morphogenesis
negative regulation of transcription, DNA-templated
embryonic morphogenesis
cranial suture morphogenesis
ossification
chondrocyte development
osteoblast development
outflow tract septum morphogenesis
outflow tract morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endochondral bone growth
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
anterior/posterior pattern specification
signal transduction involved in regulation of gene expression
embryonic limb morphogenesis
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of epithelial cell differentiation
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
wound healing, spreading of epidermal cells
embryonic nail plate morphogenesis
wound healing
odontogenesis of dentin-containing tooth
odontogenesis
embryonic digit morphogenesis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of fat cell differentiation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
stem cell differentiation
cartilage development
positive regulation of catagen
bone trabecula formation
bone morphogenesis
frontal suture morphogenesis
branching involved in mammary gland duct morphogenesis
mammary gland epithelium development
enamel mineralization
cellular response to growth factor stimulus
cellular response to estradiol stimulus
activation of meiosis
positive regulation of mesenchymal cell apoptotic process
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