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Gibco

Mouse IL-4 Recombinant Protein

查看其它 Mouse IL-4 Protein货号
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产品信息

PMC0046

应用 建议稀释比 已发表文章

免疫印迹 (WB)

 Assay-dependent -

免疫组化 (IHC)

 Assay-dependent -

酶联免疫吸附实验 (ELISA)

 Assay-dependent -

功能检测 (FN)

 Assay-dependent -

对照试剂 (Ctrl)

 Assay-dependent -
产品规格

种属

 Mouse

表达系统

 E. coli

氨基酸序列

 MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S

分子量

 14 kDa

分类

 Recombinant

类型

 Protein

纯度

 >95% by SDS-PAGE and RP-HPLC

活性

 ED50 ≤ 2 ng/mL; determined by the dose-dependent proliferation of mouse HT-2 cells.

偶联物

 Unconjugated

形式

 Lyophilized

纯化类型

 sequential chromatography

保存液

 10mM sodium citrate, pH 3

内含物

 no preservative

保存条件

 -20°C

产品详细信息

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Lyophilized mIL-4 should be reconstituted in sterile, deionized water to a concentration of 0.1-1.0 mg/mL to regain full activity. For long term storage, it is recommended to add a carrier protein, such as 0.1% HSA or BSA.

Storage: This lyophilized preparation is stable at room temperature for 3 weeks, but should be stored desiccated below -18°C. Upon reconstitution, the preparation is stable at 4°C for up to 1 week, but should be stored below -18°C for long term storage. Avoid repeated freeze/thaw cycles.

靶标信息

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; H-IL-4; IGG1 induction factor; IL-4; ILN; Interleukin; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402

基因别名: BSF-1; Il-4; Il4

UniProt ID: (Mouse) P07750

Entrez Gene ID: (Mouse) 16189

分子生物学功能: interleukin superfamily

功能
microglial cell activation positive regulation of protein phosphorylation innate immune response in mucosa positive regulation of defense response to virus by host T-helper 1 cell lineage commitment positive regulation of immunoglobulin production negative regulation of acute inflammatory response negative regulation of chronic inflammatory response immune response cholesterol metabolic process positive regulation of cell proliferation regulation of proton transport negative regulation of epithelial cell migration positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production T-helper 2 cell cytokine production positive regulation of T cell proliferation positive regulation of activated T cell proliferation B cell activation positive regulation of tyrosine phosphorylation of Stat5 protein defense response to protozoan negative regulation of macrophage activation positive regulation of mast cell degranulation negative regulation of nitric oxide biosynthetic process T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response negative regulation of T cell activation positive regulation of B cell activation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of mononuclear cell migration dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of myoblast fusion negative regulation of complement-dependent cytotoxicity negative regulation of T-helper 17 cell differentiation negative regulation of endothelial cell apoptotic process positive regulation of eosinophil chemotaxis negative regulation of extrinsic apoptotic signaling pathway
参与通路
cytokine activity cytokine receptor binding interleukin-4 receptor binding growth factor activity

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