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Proteintech
PDK1 Polyclonal Antibody
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产品信息
18262-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PDK1 Fusion Protein Ag13121 (1-436 aa encoded by BC039158)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is specific to PDK1.
Immunogen sequence: MRLARLLRG AALAGPGPGL RAAGFSRSFS SDSGSSPASE RGVPGQVDFY ARFSPSPLSM KQFLDFGSVN ACEKTSFMFL RQELPVRLAN IMKEISLLPD NLLRTPSVQL VQSWYIQSLQ ELLDFKDKSA EDAKAIYDFT DTVIRIRNRH NDVIPTMAQG VIEYKESFGV DPVTSQNVQY FLDRFYMSRI SIRMLLNQHS LLFGGKGKGS PSHRKHIGSI NPNCNVLEVI KDGYENARRL CDLYYINSPE LELEELNAKS PGQPIQVVYV PSHLYHMVFE LFKNAMRATM EHHANRGVYP PIQVHVTLGN EDLTVKMSDR GGGVPLRKID RLFNYMYSTA PRPRVETSRA VPLAGFGYGL PISRLYAQYF QGDLKLYSLE GYGTDAVIYI KALSTDSIER LPVYNKAAWK HYNTNHEADD WCVPSREPKD MTTFRSA (1-436 aa encoded by BC039158)
靶标信息
PDK1 (pyruvate dehydrogenase kinase, isozyme 1) gene, located on chromosome 2q31.1, encodes a member of the pyruvate dehydrogenase kinase family. This kinase plays a crucial role in the regulation of glucose metabolism by phosphorylating and inactivating the pyruvate dehydrogenase complex (PDC), which converts pyruvate to acetyl-CoA, linking glycolysis to the Krebs cycle. Structurally, the PDK1 protein contains a kinase domain that is essential for its enzymatic activity. PDK1 acts as a gatekeeper of glucose oxidation and is tightly regulated by various metabolic signals, including insulin and hypoxia. Dysregulation of PDK1 activity has been implicated in metabolic disorders such as diabetes and cancer, where it contributes to altered cellular energy homeostasis and metabolic reprogramming.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; isoenzyme 1; kinase isoenzyme 1; lipoamide; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; PDK p48; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 1; Pyruvate dehydrogenase kinase isoform 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
基因别名: B830012B01; D530020C15Rik; PDHK1; PDK1
UniProt ID: (Human) Q15118, (Mouse) Q8BFP9
Entrez Gene ID: (Human) 5163, (Rat) 116551, (Mouse) 228026
protein kinase activity
pyruvate dehydrogenase (acetyl-transferring) kinase activity
protein binding
ATP binding
protein serine/threonine kinase activity
protein complex binding
protein homodimerization activity
protein heterodimerization activity
nucleotide binding
kinase activity
transferase activity
non-receptor serine/threonine protein kinase
glucose metabolic process
protein phosphorylation
cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of glucose metabolic process
hypoxia-inducible factor-1alpha signaling pathway
mitophagy in response to mitochondrial depolarization
cell surface receptor signaling pathway
peptidyl-serine phosphorylation
carbohydrate metabolic process
phosphorylation
intracellular signal transduction
