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Invitrogen
PLSCR1 Monoclonal Antibody (13A6 [TEC-23])
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![PLSCR1 Monoclonal Antibody (13A6 [TEC-23])](https://www.thermofisher.cn/antibody/images/magellan/antigen/MA5-28630_PLSCR1_P58195-1_House_mouse_PDP.jpeg)
产品信息
MA5-28630
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
13A6 [TEC-23]
抗原
Pooled lipid rafts isolated from RBL-2H3 cells
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
15mM sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody binds to an intracellular epitope of rat Phospholipid Scramblase 1 (PLSCR1), an 37-49 kDa protein, accelerating bidirectional movement of plasma membrane phospholipids under conditions of elevated calcium.
Western Blot: Both reducing and non-reducing conditions.
靶标信息
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca(2+)-dependent phospholipid scramblase 1; Mg(2+)-dependent nuclease; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1
基因别名: Plscr1
UniProt ID: (Rat) P58195
Entrez Gene ID: (Rat) 117540
phosphatidylserine biosynthetic process
apoptotic process
acute-phase response
immune response
positive regulation of gene expression
phospholipid transport
phospholipid scrambling
myeloid cell differentiation
negative regulation of protein binding
regulation of mast cell activation
response to interferon-alpha
response to interferon-beta
positive regulation of apoptotic process
negative regulation of viral genome replication
positive regulation of innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of Fc receptor mediated stimulatory signaling pathway
phosphatidylserine exposure on apoptotic cell surface
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
