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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
This antibody detects endogenous protein at a molecular weight of 121 kDa.
Purity is >95% by SDS-PAGE.
POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121) or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spiced isoforms and belongs to the POM121 family. Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to nucleus membrane and endoplasmic reticulum membrane. An essential component of the nuclear pore complex (NPC), POM121 is mandatory for nuclear envelope formation and may play a role in biogenesis of the NPC. POM121 associates with the central spoke ring complex and is involved in anchoring components of the pore complex to the pore membrane by way of its F-X-F-G repeat-containing domain. POM121 overexpression induces the formation of cytoplasmic annulate lamellae (AL).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Nuclear envelope pore membrane protein POM 121; nuclear pore membrane glycoprotein 121 kD; nuclear pore membrane protein 121; Nucleoporin Nup121; P145; POM121 membrane glycoprotein; POM121B; Pore membrane protein of 121 kDa
基因别名: 2610027A18Rik; C80273; mKIAA0618; Nup121; Pom121
UniProt ID: (Rat) P52591, (Mouse) Q8K3Z9
Entrez Gene ID: (Rat) 113975, (Mouse) 107939