应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫组化(石蜡) (IHC (P)) |
1:50-1:100 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Peptide sequence around phosphorylation site of threonine 599 (L-A-T(p)-V-K) derived from Human B-RAF. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2554106 |
A suggested positive control for IHC is human breast carcinoma.
B-raf belongs to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in the gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 94 kDa B-raf protein; B-Raf proto-oncogene serine/threonine-protein kinase (p94); FLJ95109; MGC126806; murine sarcoma viral (v-raf) oncogene homolog B1; p94; Proto-oncogene B-Raf; Serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-Raf murine sarcoma viral oncogene homolog B1
基因别名: 9930012E13Rik; AA120551; AA387315; AA473386; B-raf; B-RAF1; BRAF; Braf-2; BRAF1; Braf2; C230098H17; C87398; D6Ertd631e; NS7; RAFB1
UniProt ID: (Human) P15056, (Mouse) P28028
Entrez Gene ID: (Human) 673, (Rat) 114486, (Mouse) 109880