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Invitrogen

Phospho-CaMKII beta/gamma/delta (Thr287) Polyclonal Antibody

高级验证

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

4个已发表图片
6 篇参考文献
查看其他6个CaMKII beta/gamma/delta抗体
Datasheet Created with sketchtool. 说明书
Protocols 实验方案
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Datasheet Created with sketchtool. 说明书
Protocols 实验方案
Tech Support Created with sketchtool. 技术支持

产品信息

PA5-37833

应用 建议稀释比 已发表文章

免疫印迹 (WB)

 1:500-1:1,000 查看5篇已发表文章 5篇已发表文章

其他PubMed (Misc)

 - 查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

 Rabbit / IgG

分类

 Polyclonal

类型

 Antibody

抗原

Peptide sequence around phosphorylation site of Threonine 287 (Q-E-T(p)-V-E) derived from Human CaMK2- beta/ gamma/ delta

偶联物

 Unconjugated

形式

 Liquid

浓度

 1 mg/mL

纯化类型

 Affinity chromatography

保存液

 PBS, pH 7.4, with 50% glycerol, 150mM NaCl

内含物

 0.02% sodium azide

保存条件

 -20°C

RRID

AB_2554441

产品详细信息

A suggested positive control for Western blot is rat brain cells.

靶标信息

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II beta subunit; CaM kinase II delta subunit; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM kinase II subunit gamma; CaM-kinase II beta chain; CaM-kinase II delta chain; caM-kinase II gamma chain; CaMK II; CaMK-II delta subunit; caMK-II subunit beta; caMK-II subunit delta; caMK-II subunit gamma; proline rich calmodulin-dependent protein kinase

基因别名: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CAMK; CaMK II; CAMK-II; CAMK1; CAMK2; CAMK2B; CAMK2D; CAMK2G; CAMKB; CAMKD; CAMKG; Camki; Ck2b; Kiaa4163; RATCAMKI

UniProt ID: (Human) Q13554, (Human) Q13557, (Human) Q13555, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2, (Mouse) Q923T9, (Rat) P11730

Entrez Gene ID: (Human) 816, (Human) 817, (Human) 818, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058, (Mouse) 12325, (Rat) 171140

分子生物学功能: non-receptor serine/threonine protein kinase

功能
MAPK cascade protein phosphorylation signal transduction positive regulation of neuron projection development regulation of skeletal muscle adaptation positive regulation of phospholipase A2 activity positive regulation of GTPase activity protein autophosphorylation regulation of long-term neuronal synaptic plasticity cell projection morphogenesis regulation of synapse structural plasticity regulation of calcium ion transport interferon-gamma-mediated signaling pathway regulation of dendritic spine development positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation regulation of cellular response to heat G1/S transition of mitotic cell cycle regulation of cell growth response to hypoxia regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter calcium ion transport regulation of heart contraction regulation of G2/M transition of mitotic cell cycle positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of smooth muscle cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular potassium ion homeostasis endoplasmic reticulum calcium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of smooth muscle cell proliferation protein oligomerization relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of histone deacetylase activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of sodium ion transmembrane transporter activity protein dephosphorylation nervous system development insulin secretion cell differentiation inhibitory G-protein coupled receptor phosphorylation regulation of synaptic transmission, cholinergic response to cadmium ion neuromuscular process controlling balance long-term synaptic potentiation activation of meiosis involved in egg activation positive regulation of apoptotic signaling pathway phosphorylation regulation of sodium ion transport cardiac muscle contraction response to oxidative stress multicellular organism development
参与通路
actin binding protein serine/threonine kinase activity calmodulin-dependent protein kinase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding protein kinase binding protein homodimerization activity phospholipase binding sodium channel inhibitor activity titin binding ion channel binding nitric-oxide synthase binding calcium-dependent protein serine/threonine phosphatase activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

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