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Invitrogen
Phospho-PLCg1 (Tyr783) Recombinant Rabbit Monoclonal Antibody (PLCG1Y783-C4)
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Phospho-PLCg1 (Tyr783) Antibody (MA5-37026) in Flow
Flow cytometry of Phospho-PLCg1 (Tyr783) using HeLa cells. Samples were incubated in monoclonal Phospho-PLCg1 (Tyr783) antibody (Product # MA5-37026) with a dilution of 0.05 µg/mL. Images correspond with the following conditions: negative control (blue) treated with imatinib (red) treated with pervanadate (green) treated with PV/blocked with non-phospho- peptide (violet), treated with PV/blocked with phosph... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-37026
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PLCG1Y783-C4
抗原
A synthetic phospho-peptide corresponding to residues surrounding Tyr783 of human phospho PLCg1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with 50% glycerol, 0.10% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The mammalian Phospholipase Cg (PLCg) family has two closely related proteins, PLCg1 and PLCg2. The PLCg isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; cell differentiation and embryonic development; EC 3.1.4.11; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; OTTHUMP00000178982; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-1; phospholipase C-148; phospholipase C-gamma; phospholipase C-II; Phospholipase C2; PLC gamma1; PLC-148; PLC-gamma-1; PLC2I; similar to PLC gamma 1; triphosphoinositide phosphodiesterase; unnamed protein product
基因别名: Cded; IDAA; NCKAP3; Plc-1; Plc-gamma1; PLC-II; PLC1; PLC148; Plcg-1; PLCgamma1
UniProt ID: (Human) P19174, (Mouse) Q62077
Entrez Gene ID: (Human) 5335, (Mouse) 18803
phosphatidylinositol phospholipase C activity
phospholipase C activity
guanyl-nucleotide exchange factor activity
neurotrophin TRKA receptor binding
calcium ion binding
protein binding
phosphoric diester hydrolase activity
protein kinase binding
phosphatidylinositol phospholipase C activity
lysophospholipase C activity
insulin receptor binding
receptor tyrosine kinase binding
glutamate receptor binding
phosphoprotein binding
negative regulation of inflammatory response to antigenic stimulus
lipid metabolic process
signal transduction
epidermal growth factor receptor signaling pathway
phospholipid catabolic process
positive regulation of epithelial cell migration
cell migration
calcium-mediated signaling
intracellular signal transduction
Fc-epsilon receptor signaling pathway
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
phosphatidylinositol metabolic process
phosphatidylinositol-mediated signaling
antigen receptor-mediated signaling pathway
T cell receptor signaling pathway
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
cellular response to epidermal growth factor stimulus
positive regulation of vascular endothelial cell proliferation
positive regulation of endothelial cell apoptotic process
in utero embryonic development
calcium ion transport
positive regulation of cell migration
phosphatidylinositol catabolic process
inositol trisphosphate metabolic process
inositol trisphosphate biosynthetic process
positive regulation of cell size
modulation of synaptic transmission
positive regulation of wound healing
regulation of store-operated calcium channel activity
response to curcumin
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