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Invitrogen
Phospho-Rb (Thr356) Polyclonal Antibody
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Product Details
OPA1-03200
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide based on the threonine 356 region of human Rb.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
RRID
Product Specific Information
OPA1-03200 detects phosphorylated Rb (retinoblastoma protein) (Thr356) from human samples.
OPA1-03200 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~110 kDa protein representing phospho-Rb from Jurkat cell lysate.
The OPA1-03200 immunizing peptide is based on the threonine 356 region of human Rb. This sequence is 80% and 87% conserved in mice and rat, respectively.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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