Product References
Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model.
Scientific reports
Patel RS,Lui A,Hudson C,Moss L,Sparks RP,Hill SE,Shi Y,Cai J,Blair LJ,Bickford PC,Patel NA
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Fri Jan 06 00:00:00 UTC 2023
Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo.
Frontiers in molecular neuroscience
Vemula P,Schoch KM,Miller TM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Sat Feb 10 00:00:00 UTC 2024
Aberrant accumulation of age- and disease-associated factors following neural probe implantation in a mouse model of Alzheimer's disease.
Journal of neural engineering
Wellman SM,Coyne OA,Douglas MM,Kozai TDY
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Fri Sep 01 00:00:00 UTC 2023
APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading.
The Journal of clinical investigation
Wang C,Nambiar A,Strickland MR,Lee C,Parhizkar S,Moore AC,Musiek ES,Ulrich JD,Holtzman DM
MN1020B was used in Immunohistochemistry to suggest that the APOE-ε4 genotype is a critical modifier in the development of AD pathology in response to SD.
Mon Jul 17 00:00:00 UTC 2023
NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase.
Phytotherapy research : PTR
Lv J,Shen X,Shen X,Zhao S,Xu R,Yan Q,Lu J,Zhu D,Zhao Y,Dong J,Wang J,Shen X
MN1020B was used in Immunohistochemistry to determine the effect of triterpene saponin NPLC0393 from G. pentaphyllum on AD-like pathology in 3Tg-AD mice and elucidate the underlying mechanisms.
Sun Oct 01 00:00:00 UTC 2023
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration.
The Journal of experimental medicine
Ishida K,Yamada K,Nishiyama R,Hashimoto T,Nishida I,Abe Y,Yasui M,Iwatsubo T
MN1020B was used in Immunohistochemistry to study the mechanisms facilitating the elimination of extracellular tau from the brain to CSF and subsequently to deep cervical lymph node, in the Glymphatic clearance system.
Mon Mar 07 00:00:00 UTC 2022
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration.
The Journal of experimental medicine
Ishida K,Yamada K,Nishiyama R,Hashimoto T,Nishida I,Abe Y,Yasui M,Iwatsubo T
MN1020B was used in Immunohistochemistry to study the mechanisms facilitating the elimination of extracellular tau from the brain to CSF and subsequently to deep cervical lymph node, in the Glymphatic clearance system.
Mon Mar 07 00:00:00 UTC 2022
APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model.
Annals of neurology
Gratuze M,Jiang H,Wang C,Xiong M,Bao X,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Wed Jun 01 00:00:00 UTC 2022
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
Scientific reports
McKee CA,Lee J,Cai Y,Saito T,Saido T,Musiek ES
MN1020B was used in Immunohistochemistry to demonstrate that the astrocyte activation induced by Bmal1 knockout does not influence Aβ deposition.
Wed Feb 02 00:00:00 UTC 2022
Inhibition of unfolded protein response prevents post-anesthesia neuronal hyperactivity and synapse loss in aged mice.
Aging cell
Chen K,Hu Q,Gupta R,Stephens J,Xie Z,Yang G
MN1020B was used in Immunohistochemistry to suggest that sevoflurane anesthesia causes abnormal UPR in the aged brain, which contributes to neuronal hyperactivity, synapse loss and cognitive decline in aged mice.
Fri Apr 01 00:00:00 UTC 2022
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
The Journal of clinical investigation
Sandusky-Beltran LA,Kovalenko A,Placides DS,Ratnasamy K,Ma C,Hunt JB,Liang H,Calahatian JIT,Michalski C,Fahnestock M,Blair LJ,Darling AL,Baker JD,Fontaine SN,Dickey CA,Gamsby JJ,Nash KR,Abner E,Selenica MB,Lee DC
MN1020B was used in Immunohistochemistry (Frozen) to report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate.
Mon Feb 15 00:00:00 UTC 2021
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Neuron
Wang C,Xiong M,Gratuze M,Bao X,Shi Y,Andhey PS,Manis M,Schroeder C,Yin Z,Madore C,Butovsky O,Artyomov M,Ulrich JD,Holtzman DM
MN1020B was used in Immunocytochemistry-immunoflourescence to investigate The cell-specific role of each form of apoE in the setting of neurodegeneration.
Wed May 19 00:00:00 UTC 2021
Activated microglia mitigate Aβ-associated tau seeding and spreading.
The Journal of experimental medicine
Gratuze M,Chen Y,Parhizkar S,Jain N,Strickland MR,Serrano JR,Colonna M,Ulrich JD,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Aug 02 00:00:00 UTC 2021
Activated microglia mitigate Aβ-associated tau seeding and spreading.
The Journal of experimental medicine
Gratuze M,Chen Y,Parhizkar S,Jain N,Strickland MR,Serrano JR,Colonna M,Ulrich JD,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Aug 02 00:00:00 UTC 2021
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Annals of neurology
Litvinchuk A,Huynh TV,Shi Y,Jackson RJ,Finn MB,Manis M,Francis CM,Tran AC,Sullivan PM,Ulrich JD,Hyman BT,Cole T,Holtzman DM
MN1020B was used in Immunohistochemistry, ELISA to conclude that reducing ApoE4 levels should be explored further as a therapeutic approach for APOE4 carriers with tauopathy including Alzheimer's disease.
Sat May 01 00:00:00 UTC 2021
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Annals of neurology
Litvinchuk A,Huynh TV,Shi Y,Jackson RJ,Finn MB,Manis M,Francis CM,Tran AC,Sullivan PM,Ulrich JD,Hyman BT,Cole T,Holtzman DM
MN1020B was used in Immunohistochemistry, ELISA to conclude that reducing ApoE4 levels should be explored further as a therapeutic approach for APOE4 carriers with tauopathy including Alzheimer's disease.
Sat May 01 00:00:00 UTC 2021
Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets.
Journal of neuropathology and experimental neurology
Schwerin SC,Chatterjee M,Hutchinson EB,Djankpa FT,Armstrong RC,McCabe JT,Perl DP,Juliano SL
MN1020B was used in Immunohistochemistry to evaluate glia and forms of tau following blast exposure in the cerebral cortex of ferrets.
Wed Jan 20 00:00:00 UTC 2021
Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer's Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques.
Frontiers in pharmacology
Su D,Chai Y,Yang J,Wang X,Liu Y,Ma J,Tang X,Mishra C,Chandra SR,Yue W,Ai J
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Fri May 14 00:00:00 UTC 2021
Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer's Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques.
Frontiers in pharmacology
Su D,Chai Y,Yang J,Wang X,Liu Y,Ma J,Tang X,Mishra C,Chandra SR,Yue W,Ai J
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Fri May 14 00:00:00 UTC 2021
Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer's Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques.
Frontiers in pharmacology
Su D,Chai Y,Yang J,Wang X,Liu Y,Ma J,Tang X,Mishra C,Chandra SR,Yue W,Ai J
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Fri May 14 00:00:00 UTC 2021
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Communications biology
Dong Y,Liang F,Huang L,Fang F,Yang G,Tanzi RE,Zhang Y,Quan Q,Xie Z
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Wed May 12 00:00:00 UTC 2021
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Communications biology
Dong Y,Liang F,Huang L,Fang F,Yang G,Tanzi RE,Zhang Y,Quan Q,Xie Z
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Wed May 12 00:00:00 UTC 2021
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Communications biology
Dong Y,Liang F,Huang L,Fang F,Yang G,Tanzi RE,Zhang Y,Quan Q,Xie Z
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Wed May 12 00:00:00 UTC 2021
Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease.
ASN neuro
York A,Everhart A,Vitek MP,Gottschalk KW,Colton CA
MN1020B was used in Immunohistochemistry to demonstrate that metabolic adaptations in the brain are critical to the establishment and maintenance of normal cellular functions and to the pathological responses to disease processes.
Thu Jan 13 00:00:00 UTC 2022
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
The Journal of biological chemistry
Nies SH,Takahashi H,Herber CS,Huttner A,Chase A,Strittmatter SM
MN1020B was used in Immunohistochemistry to assesses the impact of Aβ copathology, of deleting loci known to modify Alzheimer's disease risk (Ptk2b, Grn, and Tmem106b) and of pharmacological intervention with an Fyn kinase inhibitor on tau spreading after injection of AD tau extracts.
Fri Oct 01 00:00:00 UTC 2021
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.
Acta neuropathologica communications
Lam S,Petit F,Hérard AS,Boluda S,Eddarkaoui S,Guillermier M,Buée L,Duyckaerts C,Haïk S,Picq JL,Dhenain M
MN1020B was used in Immunohistochemistry to understand the cognitive repercussions of tau in individuals who do not develop cerebral hemorrhages.
Tue Oct 12 00:00:00 UTC 2021
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Nature aging
Dehkordi SK,Walker J,Sah E,Bennett E,Atrian F,Frost B,Woost B,Bennett RE,Orr TC,Zhou Y,Andhey PS,Colonna M,Sudmant PH,Xu P,Wang M,Zhang B,Zare H,Orr ME
MN1020B was used in Immunohistochemistry to show that CDKN2D/p19-expressing neurons with NFTs represent a unique cellular population in human AD with a senescence phenotype.
Wed Dec 01 00:00:00 UTC 2021
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
MN1020B was used in Immunohistochemistry, ELISA to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 UTC 2020
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
MN1020B was used in Immunohistochemistry, ELISA to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 UTC 2020
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
MN1020B was used in Immunohistochemistry, ELISA to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 UTC 2020
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
MN1020B was used in Immunohistochemistry, ELISA to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 UTC 2020
Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.
Neurobiology of aging
Guillemaud O,Ceyzériat K,Saint-Georges T,Cambon K,Petit F,Ben Haim L,Carrillo-de Sauvage MA,Guillermier M,Bernier S,Hérard AS,Joséphine C,Bémelmans AP,Brouillet E,Hantraye P,Bonvento G,Escartin C
MN1020B was used in Immunohistochemistry to evaluate whether reactive astrocytes contribute to tau as well as amyloid pathologies in the hippocampus of 3xTg-AD mice, an AD model that develops tau hyper-phosphorylation and amyloid deposition.
Mon Jun 01 00:00:00 UTC 2020
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Acta neuropathologica communications
Laversenne V,Nazeeruddin S,Källstig EC,Colin P,Voize C,Schneider BL
MN1020B was used in Immunohistochemistry (Frozen) to enhance microglial activity around neuritic plaques, mitigating part of the tau-induced pathological manifestations.
Mon Nov 23 00:00:00 UTC 2020
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Acta neuropathologica communications
Laversenne V,Nazeeruddin S,Källstig EC,Colin P,Voize C,Schneider BL
MN1020B was used in Immunohistochemistry (Frozen) to enhance microglial activity around neuritic plaques, mitigating part of the tau-induced pathological manifestations.
Mon Nov 23 00:00:00 UTC 2020
Morphological and molecular alterations of reactive astrocytes without proliferation in cerebral cortex of an APP/PS1 transgenic mouse model and Alzheimer's patients.
Glia
Li KY,Gong PF,Li JT,Xu NJ,Qin S
MN1020B was used in ELISA, Immunohistochemistry (Paraffin) to provide a morphological and molecular basis with which to understand the function and mechanism of reactive astrocytes in the progression of AD.
Sun Nov 01 00:00:00 UTC 2020
NLRP3 inflammasome activation drives tau pathology.
Nature
Ising C,Venegas C,Zhang S,Scheiblich H,Schmidt SV,Vieira-Saecker A,Schwartz S,Albasset S,McManus RM,Tejera D,Griep A,Santarelli F,Brosseron F,Opitz S,Stunden J,Merten M,Kayed R,Golenbock DT,Blum D,Latz E,Buée L,Heneka MT
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Fri Nov 01 00:00:00 UTC 2019
NLRP3 inflammasome activation drives tau pathology.
Nature
Ising C,Venegas C,Zhang S,Scheiblich H,Schmidt SV,Vieira-Saecker A,Schwartz S,Albasset S,McManus RM,Tejera D,Griep A,Santarelli F,Brosseron F,Opitz S,Stunden J,Merten M,Kayed R,Golenbock DT,Blum D,Latz E,Buée L,Heneka MT
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Fri Nov 01 00:00:00 UTC 2019
TREM2 function impedes tau seeding in neuritic plaques.
Nature neuroscience
Leyns CEG,Gratuze M,Narasimhan S,Jain N,Koscal LJ,Jiang H,Manis M,Colonna M,Lee VMY,Ulrich JD,Holtzman DM
MN1020B was used in Immunohistochemistry to demonstrate a key role for triggering receptor expressed on myeloid cells 2 and microglia in limiting the development of peri-plaque tau pathologies.
Thu Aug 01 00:00:00 UTC 2019
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
The Journal of experimental medicine
Shi Y,Manis M,Long J,Wang K,Sullivan PM,Remolina Serrano J,Hoyle R,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Nov 04 00:00:00 UTC 2019
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
The Journal of experimental medicine
Shi Y,Manis M,Long J,Wang K,Sullivan PM,Remolina Serrano J,Hoyle R,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Nov 04 00:00:00 UTC 2019
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
The Journal of experimental medicine
Shi Y,Manis M,Long J,Wang K,Sullivan PM,Remolina Serrano J,Hoyle R,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Nov 04 00:00:00 UTC 2019
Distribution of endogenous normal tau in the mouse brain.
The Journal of comparative neurology
Kubo A,Misonou H,Matsuyama M,Nomori A,Wada-Kakuda S,Takashima A,Kawata M,Murayama S,Ihara Y,Miyasaka T
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Mon Apr 01 00:00:00 UTC 2019
Distribution of endogenous normal tau in the mouse brain.
The Journal of comparative neurology
Kubo A,Misonou H,Matsuyama M,Nomori A,Wada-Kakuda S,Takashima A,Kawata M,Murayama S,Ihara Y,Miyasaka T
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Mon Apr 01 00:00:00 UTC 2019
Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients.
Frontiers in cellular neuroscience
Metaxas A,Thygesen C,Briting SRR,Landau AM,Darvesh S,Finsen B
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Thu Oct 01 00:00:00 UTC 2020
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.
Acta neuropathologica communications
Gary C,Lam S,Hérard AS,Koch JE,Petit F,Gipchtein P,Sawiak SJ,Caillierez R,Eddarkaoui S,Colin M,Aujard F,Deslys JP,Brouillet E,Buée L,Comoy EE,Pifferi F,Picq JL,Dhenain M
MN1020B was used in Immunohistochemistry to demonstrate long term memory and learning impairments in a non-human primate following intracerebral injections with Alzheimer human brain extracts.
Wed Sep 04 00:00:00 UTC 2019
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Science advances
Dominy SS,Lynch C,Ermini F,Benedyk M,Marczyk A,Konradi A,Nguyen M,Haditsch U,Raha D,Griffin C,Holsinger LJ,Arastu-Kapur S,Kaba S,Lee A,Ryder MI,Potempa B,Mydel P,Hellvard A,Adamowicz K,Hasturk H,Walker GD,Reynolds EC,Faull RLM,Curtis MA,Dragunow M,Potempa J
MN1020B was used in Immunohistochemistry to study porphyromonas gingivalis in Alzheimer's disease brains.
Tue Jan 01 00:00:00 UTC 2019
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Cell reports
Wu T,Dejanovic B,Gandham VD,Gogineni A,Edmonds R,Schauer S,Srinivasan K,Huntley MA,Wang Y,Wang TM,Hedehus M,Barck KH,Stark M,Ngu H,Foreman O,Meilandt WJ,Elstrott J,Chang MC,Hansen DV,Carano RAD,Sheng M,Hanson JE
MN1020B was used in Immunohistochemistry to demonstrate that complement activation contributes to neurodegeneration caused by tau pathology and suggest that blocking C3 function might be protective in AD and other tauopathies.
Tue Aug 20 00:00:00 UTC 2019
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.
Acta neuropathologica communications
Christensen KR,Beach TG,Serrano GE,Kanaan NM
MN1020B was used in Immunohistochemistry-immunofluorescence to study the importance of targeting tau deposition in Alzheimer's disease, ideally in the initial phases of its deposition in axons.
Thu Feb 28 00:00:00 UTC 2019
Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system.
The Journal of biological chemistry
Murphy K,Llewellyn K,Wakser S,Pontasch J,Samanich N,Flemer M,Hensley K,Kim DS,Park J
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Western Blot
Fri Nov 23 00:00:00 UTC 2018
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature
Shi Y,Yamada K,Liddelow SA,Smith ST,Zhao L,Luo W,Tsai RM,Spina S,Grinberg LT,Rojas JC,Gallardo G,Wang K,Roh J,Robinson G,Finn MB,Jiang H,Sullivan PM,Baufeld C,Wood MW,Sutphen C,McCue L,Xiong C,Del-Aguila JL,Morris JC,Cruchaga C,Fagan AM,Miller BL,Boxer AL,Seeley WW,Butovsky O,Barres BA,Paul SM,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Thu Sep 28 00:00:00 UTC 2017
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature
Shi Y,Yamada K,Liddelow SA,Smith ST,Zhao L,Luo W,Tsai RM,Spina S,Grinberg LT,Rojas JC,Gallardo G,Wang K,Roh J,Robinson G,Finn MB,Jiang H,Sullivan PM,Baufeld C,Wood MW,Sutphen C,McCue L,Xiong C,Del-Aguila JL,Morris JC,Cruchaga C,Fagan AM,Miller BL,Boxer AL,Seeley WW,Butovsky O,Barres BA,Paul SM,Holtzman DM
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Thu Sep 28 00:00:00 UTC 2017
Neurodegeneration Enhances the Development of Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Lang SC,Harre U,Purohit P,Dietel K,Kienhöfer D,Hahn J,Baum W,Herrmann M,Schett G,Mielenz D
MN1020B was used in immunohistochemistry to report that neurodegenerative disease enhances arthritis development
Wed Mar 15 00:00:00 UTC 2017
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy.
Brain research
Puvenna V,Engeler M,Banjara M,Brennan C,Schreiber P,Dadas A,Bahrami A,Solanki J,Bandyopadhyay A,Morris JK,Bernick C,Ghosh C,Rapp E,Bazarian JJ,Janigro D
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Fri Jan 01 00:00:00 UTC 2016
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy.
Brain research
Puvenna V,Engeler M,Banjara M,Brennan C,Schreiber P,Dadas A,Bahrami A,Solanki J,Bandyopadhyay A,Morris JK,Bernick C,Ghosh C,Rapp E,Bazarian JJ,Janigro D
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Fri Jan 01 00:00:00 UTC 2016
Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism.
Cell death & disease
Foxton R,Osborne A,Martin KR,Ng YS,Shima DT
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunofluorescence
Thu May 05 00:00:00 UTC 2016
BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR.
PloS one
Makani V,Jang YG,Christopher K,Judy W,Eckstein J,Hensley K,Chiaia N,Kim DS,Park J
MN1020B was used in western blot to study Midi-GAGR for neuroprotection, neurotrophic polysaccharide, and BBB-permeable
Tue Aug 09 00:00:00 UTC 2016
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.
Alzheimer's & dementia (New York, N. Y.)
Levenson JM,Schroeter S,Carroll JC,Cullen V,Asp E,Proschitsky M,Chung CH,Gilead S,Nadeem M,Dodiya HB,Shoaga S,Mufson EJ,Tsubery H,Krishnan R,Wright J,Solomon B,Fisher R,Gannon KS
MN1020B was used in Immunohistochemistry to establish NPT088 as a novel therapeutic approach and potential drug class that targets both Aβ and tau.
Thu Sep 01 00:00:00 UTC 2016
Expanding the spectrum of neuronal pathology in multiple system atrophy.
Brain : a journal of neurology
Cykowski MD,Coon EA,Powell SZ,Jenkins SM,Benarroch EE,Low PA,Schmeichel AM,Parisi JE
MN1020B was used in Immunohistochemistry to suggest that alongside glial inclusions, neuronal pathology plays an important role in the developmental and progression of multiple system atrophy.
Sat Aug 01 00:00:00 UTC 2015
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Human molecular genetics
Blum D,Herrera F,Francelle L,Mendes T,Basquin M,Obriot H,Demeyer D,Sergeant N,Gerhardt E,Brouillet E,Buée L,Outeiro TF
MN1020B was used in immunocytochemistry to investigate the relationship between mutant huntingtin and Tau in murine models of Huntington's disease
Thu Jan 01 00:00:00 UTC 2015
Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.
Journal of neuropathology and experimental neurology
Tousseyn T,Bajsarowicz K,Sánchez H,Gheyara A,Oehler A,Geschwind M,DeArmond B,DeArmond SJ
MN1020B was used in immunohistochemistry to investigate the link between prion disease and Alzheimer disease
Tue Sep 01 00:00:00 UTC 2015
Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile.
PloS one
Liu P,Paulson JB,Forster CL,Shapiro SL,Ashe KH,Zahs KR
MN1020B was used in immunohistochemistry to develop and characterize a novel transgenic mouse model of Abeta toxicity.
Mon Apr 25 00:00:00 UTC 2016
Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile.
PloS one
Liu P,Paulson JB,Forster CL,Shapiro SL,Ashe KH,Zahs KR
MN1020B was used in immunohistochemistry to develop and characterize a novel transgenic mouse model of Abeta toxicity.
Mon Apr 25 00:00:00 UTC 2016
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications
Takeda S,Wegmann S,Cho H,DeVos SL,Commins C,Roe AD,Nicholls SB,Carlson GA,Pitstick R,Nobuhara CK,Costantino I,Frosch MP,Müller DJ,Irimia D,Hyman BT
MN1020B was used in Immunofluorescence to study the inter-neuron propagation of PBS-soluble phosphorylated high-molecular-weight tau in mice and humans.
Tue Oct 13 00:00:00 UTC 2015
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications
Takeda S,Wegmann S,Cho H,DeVos SL,Commins C,Roe AD,Nicholls SB,Carlson GA,Pitstick R,Nobuhara CK,Costantino I,Frosch MP,Müller DJ,Irimia D,Hyman BT
MN1020B was used in Immunofluorescence to study the inter-neuron propagation of PBS-soluble phosphorylated high-molecular-weight tau in mice and humans.
Tue Oct 13 00:00:00 UTC 2015
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
The EMBO journal
Kondadi AK,Wang S,Montagner S,Kladt N,Korwitz A,Martinelli P,Herholz D,Baker MJ,Schauss AC,Langer T,Rugarli EI
MN1020B was used in immunohistochemistry and western blot to study the mitochondrial import defects and hyperphosphorylation of tau that result from depletion of the AFG(3)L(2) subunit of the m-AAA proteinase in neurons
Fri May 02 00:00:00 UTC 2014
P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.
Aging cell
Pehar M,Ko MH,Li M,Scrable H,Puglielli L
MN1020B was used in western blot to study the role of the short p44 isoform of p53 in driving the expression of tau-phosphorylating protein kinases and the age-dependent increase in nuclear p44
Sun Jun 01 00:00:00 UTC 2014
Visualizing the microtubule-associated protein tau in the nucleus.
Science China. Life sciences
Lu J,Li T,He R,Bartlett PF,Götz J
MN1020B was used in western blot to perform a comparative study of methods for the detection of nuclear tau protein
Tue Apr 01 00:00:00 UTC 2014
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1020B was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 UTC 2014
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R
MN1020B was used in ELISA, immunohistochemistry, and western blot to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model
Wed Mar 19 00:00:00 UTC 2014
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK
MN1020B was used in immunohistochemistry and western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease
Wed May 14 00:00:00 UTC 2014
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
The American journal of pathology
Abbondante S,Baglietto-Vargas D,Rodriguez-Ortiz CJ,Estrada-Hernandez T,Medeiros R,Laferla FM
MN1020B was used in western blot to study the cognitive defects observed in type 1 diabetes and the role of tau in mediating these effects
Sat Mar 01 00:00:00 UTC 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1020B was used in immunohistochemistry and western blot to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 UTC 2014
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Journal of neurochemistry
Bonda DJ,Stone JG,Torres SL,Siedlak SL,Perry G,Kryscio R,Jicha G,Casadesus G,Smith MA,Zhu X,Lee HG
MN1020B was used in immunohistochemistry to study the involvement of neuronal leptin resistance in Alzheimer's disease
Wed Jan 01 00:00:00 UTC 2014
Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.
Journal of neurochemistry
Palm R,Chang J,Blair J,Garcia-Mesa Y,Lee HG,Castellani RJ,Smith MA,Zhu X,Casadesus G
MN1020B was used in immunohistochemistry to study the improvement in neuronal plasticity and cognition in ovariectomized Alzheimer's disease mice following serum gonadotropin down regulation
Tue Jul 01 00:00:00 UTC 2014
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Neuropharmacology
Graham DL,Gray AJ,Joyce JA,Yu D,O'Moore J,Carlson GA,Shearman MS,Dellovade TL,Hering H
MN1020B was used in immunohistochemistry and western blot to study the mechanism by which O-GlcNAcylation prevents pathological agregation of tau in a murine tauopathy model
Tue Apr 01 00:00:00 UTC 2014
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Neuropharmacology
Jiang T,Yu JT,Zhu XC,Zhang QQ,Cao L,Wang HF,Tan MS,Gao Q,Qin H,Zhang YD,Tan L
MN1020B was used in immunohistochemistry and western blot to study the ability of the rapamycin analog temsirolimus to promote autophagic clearance of hyperphosphorylated tau and improve memory deficits in animal models
Wed Oct 01 00:00:00 UTC 2014
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Neurobiology of aging
Huang XT,Qian ZM,He X,Gong Q,Wu KC,Jiang LR,Lu LN,Zhu ZJ,Zhang HY,Yung WH,Ke Y
MN1020B was used in immunohistochemistry to study the role of reduced brain iron levels in the neuroprotective effects of huperzine A in a murine model of Alzheimer's disease
Thu May 01 00:00:00 UTC 2014
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Neurobiology of aging
Orr ME,Salinas A,Buffenstein R,Oddo S
MN1020B was used in western blot to study the role of mTOR hyperactivation in the mechanism by which a high-sucrose diet promotes beta-amyloid pathology in Alzheimer's disease
Sun Jun 01 00:00:00 UTC 2014
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
Psychoneuroendocrinology
García-Mesa Y,Pareja-Galeano H,Bonet-Costa V,Revilla S,Gómez-Cabrera MC,Gambini J,Giménez-Llort L,Cristòfol R,Viña J,Sanfeliu C
MN1020B was used in western blot to study the role of BDNF in the neuropretoective effects of aerobic physical exercise in a murine model of Alzheimer's disease
Tue Jul 01 00:00:00 UTC 2014
Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?
Parkinsonism & related disorders
Pan JJ,Lee M,Honig LS,Vonsattel JP,Faust PL,Louis ED
MN1020B was used in immunohistochemistry to study the relationships between essential tremor, tau pathology and Alzheimer's disease
Sun Jun 01 00:00:00 UTC 2014
Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.
Journal of Alzheimer's disease : JAD
Dalby NO,Volbracht C,Helboe L,Larsen PH,Jensen HS,Egebjerg J,Elvang AB
MN1020B was used in immunohistochemistry to study hippocampal CA1 pyramidal neuron function in a murine tauopathy model
Thu Jan 15 00:00:00 UTC 2015
Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.
Journal of Alzheimer's disease : JAD
Lin L,Yang SS,Chu J,Wang L,Ning LN,Zhang T,Jiang Q,Tian Q,Wang JZ
MN1020B was used in western blot to study the regional expression of proteins involved in Alzheimer's disease pathology and the effect of indicung ER stress
Mon Mar 30 00:00:00 UTC 2015
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Journal of Alzheimer's disease : JAD
Yanagisawa D,Taguchi H,Ibrahim NF,Morikawa S,Shiino A,Inubushi T,Hirao K,Shirai N,Sogabe T,Tooyama I
MN1020B was used in immunohistochemistry to study the probe structural requirements for [19F] MRI detection of brain amyloid
Mon Oct 06 00:00:00 UTC 2014
Distribution of pathology in frontal variant Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Blennerhassett R,Lillo P,Halliday GM,Hodges JR,Kril JJ
MN1020B was used in immunohistochemistry to study the spacial distribution of neurodegeneration in the brains of patients with frontal variant Alzheimer's disease
Wed Sep 03 00:00:00 UTC 2014
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
FEBS letters
Inoue H,Hiradate Y,Shirakata Y,Kanai K,Kosaka K,Gotoh A,Fukuda Y,Nakai Y,Uchida T,Sato E,Tanemura K
MN1020B was used in immunohistochemistry and western blot to study the role of Tau phosphorylation in murine spermatogenesis during meiosis
Thu May 29 00:00:00 UTC 2014
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Biochimica et biophysica acta
Torres M,Price SL,Fiol-Deroque MA,Marcilla-Etxenike A,Ahyayauch H,Barceló-Coblijn G,Terés S,Katsouri L,Ordinas M,López DJ,Ibarguren M,Goñi FM,Busquets X,Vitorica J,Sastre M,Escribá PV
MN1020B was used in western blot to study the role of changes in membrane lipid composition in the therapeutic effects of 2-hydroxydocosahexaenoic acid in a murine model of Alzheimer's disease
Sun Jun 01 00:00:00 UTC 2014
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.
Acta neuropathologica communications
Lasagna-Reeves CA,Sengupta U,Castillo-Carranza D,Gerson JE,Guerrero-Munoz M,Troncoso JC,Jackson GR,Kayed R
MN1020B was used in immunohistochemistry to study the formation of tau annular protofibrils and the significance for different neurodegenerative tauopathic diseases
Thu May 29 00:00:00 UTC 2014
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
PloS one
Kim HJ,Chang KA,Ha TY,Kim J,Ha S,Shin KY,Moon C,Nacken W,Kim HS,Suh YH
MN1020B was used in immunohistochemistry to study the beneficial effects of S100A9 deletion on memory and beta-amyloid pathology in a murine model of Alzheimer's disease
Mon Dec 22 00:00:00 UTC 2014
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Biological psychiatry
Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN
MN1020B was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone
Sun Sep 01 00:00:00 UTC 2013
Clinical correlates in an experimental model of repetitive mild brain injury.
Annals of neurology
Mannix R,Meehan WP,Mandeville J,Grant PE,Gray T,Berglass J,Zhang J,Bryant J,Rezaie S,Chung JY,Peters NV,Lee C,Tien LW,Kaplan DL,Feany M,Whalen M
MN1020B was used in immunohistochemistry to use a murine model of repetetive mild brain injury to study whether the observed congnitive deficits are associated with beta-amyloid/tau pathology or ApoE allele
Mon Jul 01 00:00:00 UTC 2013
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.
Aging cell
Parrella E,Maxim T,Maialetti F,Zhang L,Wan J,Wei M,Cohen P,Fontana L,Longo VD
MN1020B was used in immunohistochemistry to study the effect of periodic protein restriction cycles on levels of IGF-1, phosphorylated tau, and cognitive performance in a murine model of Alzheimer's disease
Mon Apr 01 00:00:00 UTC 2013
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barron AM,Garcia-Segura LM,Caruso D,Jayaraman A,Lee JW,Melcangi RC,Pike CJ
MN1020B was used in immunohistochemistry to study the ability of the Ro5-4864 translocator protein ligand to protect against disease pathology and behaviour deficit in a murine model of Alzheimer's disease
Wed May 15 00:00:00 UTC 2013
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
The Journal of nutritional biochemistry
Vepsäläinen S,Koivisto H,Pekkarinen E,Mäkinen P,Dobson G,McDougall GJ,Stewart D,Haapasalo A,Karjalainen RO,Tanila H,Hiltunen M
MN1020B was used in western blot to study the beneficial effects of anthacyanin-rich bilberry and blackberry extracts on APP processing and behavioural deficits in a murine model of Alzheimer's disease
Tue Jan 01 00:00:00 UTC 2013
Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.
ACS chemical neuroscience
Chen RJ,Chang WW,Lin YC,Cheng PL,Chen YR
MN1020B was used in western blot to study the role of the Fyn pathway in the mechanism by which beta-amyloid oligomers modulate the down regulation of tau by cellular prion protein
Wed Sep 18 00:00:00 UTC 2013
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
ACS chemical neuroscience
Alonso E,Vale C,Vieytes MR,Botana LM
MN1020B was used in western blot to study the role of PKC activation in the mechanism underyling the beneficial effects of yessotoxin on tau and Abeta pathology in a cellular model of Alzheimer's disease
Wed Jul 17 00:00:00 UTC 2013
Making the diagnosis of frontotemporal lobar degeneration.
Archives of pathology & laboratory medicine
Bigio EH
MN1020B was used in immunohistochemistry to review the diagnosis of frontotemporal lobar degeneration
Fri Mar 01 00:00:00 UTC 2013
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Neurobiology of aging
Geekiyanage H,Upadhye A,Chan C
MN1020B was used in western blot to study the reduction in beta-amyloid levels and tau hyperphosphorylation in response to inhibition of serine palmitoyltransferase in a mouse model of Alzheimer's disease
Thu Aug 01 00:00:00 UTC 2013
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.
Neurobiology of aging
Colom-Cadena M,Gelpi E,Martí MJ,Charif S,Dols-Icardo O,Blesa R,Clarimón J,Lleó A
MN1020B was used in immunohistochemistry to study the relationship between MAPT haplotype and enhanced alpha-synuclein deposition in dementia with Lewy bodies
Fri Mar 01 00:00:00 UTC 2013
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Neurobiology of aging
Cancino GI,Miller FD,Kaplan DR
MN1020B was used in western blot to study the effects of p73 haploinsufficiency on tau phosphorylation status and the activity of GSK3-beta, c-Abl and Cdk5 in murine models of ageing and Alzheimer's disease
Fri Feb 01 00:00:00 UTC 2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurobiology of aging
Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D
MN1020B was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine
Sat Jun 01 00:00:00 UTC 2013
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Neurobiology of aging
Köhler C,Dinekov M,Götz J
MN1020B was used in immunohistochemistry to study the association of GSK3 activity with tau phosphorylation and neuronal tyrosine phosphorylation in a murine model expressing human P301L tau
Wed May 01 00:00:00 UTC 2013
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
Neurobiology of aging
Braak H,Thal DR,Matschke J,Ghebremedhin E,Del Tredici K
MN1020B was used in immunohistochemistry to study the presence of dendritic inclusions in catecholaminergic brainstem neurons and their increased prevalence with advancing age
Tue Jan 01 00:00:00 UTC 2013
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.
Parkinsonism & related disorders
Pirker S,Perju-Dumbrava L,Kovacs GG,Traub-Weidinger T,Asenbaum S,Pirker W
MN1020B was used in immunohistochemistry to study striatal dopamine D2 receptor binding in corticobasal syndrome
Fri Feb 01 00:00:00 UTC 2013
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Capsoni S,Carlo AS,Vignone D,Amato G,Criscuolo C,Willnow TE,Cattaneo A
MN1020B was used in immunohistochemistry to study the effect of SorLA-deficiency to dissociate amyloid and tau neurodegeneration in a novel murine model of Alzheimer's disease
Tue May 28 00:00:00 UTC 2013
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.
Journal of Alzheimer's disease : JAD
Manczak M,Reddy PH
MN1020B was used in immunohistochemistry to study the interaction of monomeric and oligomeric beta-amyloid with phosphorylated tau in the brains of Alzheimer's disease patients
Mon Jan 27 00:00:00 UTC 2014
Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.
Journal of Alzheimer's disease : JAD
Levarska L,Zilka N,Jadhav S,Neradil P,Novak M
MN1020B was used in immunohistochemistry to study the infectivity and spreading propensity of tau complexes containing the 3R or 4R human tau misfolded truncates
Fri Jun 27 00:00:00 UTC 2014
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Natunen T,Parrado AR,Helisalmi S,Pursiheimo JP,Sarajärvi T,Mäkinen P,Kurkinen KM,Mullin K,Alafuzoff I,Haapasalo A,Bertram L,Soininen H,Tanzi RE,Hiltunen M
MN1020B was used in western blot to study whether the BACE1-modulator GGA3 contributes to Alzheimer's disease pathology
Tue Apr 08 00:00:00 UTC 2014
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Brain research bulletin
Zufferey V,Vallet PG,Moeri M,Moulin-Sallanon M,Piotton F,Marin P,Savioz A
MN1020B was used in immunohistochemistry to study the neuropatholgy and behavioural abnormalities of a murine Alzheimer's disease model transgenically expressing P117L mutant presenilin-1
Wed May 01 00:00:00 UTC 2013
Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
ChemMedChem
Gu J,Anumala UR,Heyny-von Haußen R,Hölzer J,Goetschy-Meyer V,Mall G,Hilger I,Czech C,Schmidt B
MN1020B was used in immunohistochemistry to study the use of fluorescent trimethine cyanine dyes for the detection of tau fibrils in postmortem Alzheimer's disease brain
Sat Jun 01 00:00:00 UTC 2013
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
Bioorganic & medicinal chemistry
Anumala UR,Gu J,Lo Monte F,Kramer T,Heyny-von Haußen R,Hölzer J,Goetschy-Meyer V,Schön C,Mall G,Hilger I,Czech C,Herms J,Schmidt B
MN1020B was used in immunohistochemistry to study the detection of neurofibrilliary tangles in Alzheimer's disease brains using fluorescent rhodamine-3-acetic acid-based imaging probes
Sun Sep 01 00:00:00 UTC 2013
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Neuro-degenerative diseases
Flunkert S,Hierzer M,Löffler T,Rabl R,Neddens J,Duller S,Schofield EL,Ward MA,Posch M,Jungwirth H,Windisch M,Hutter-Paier B
MN1020B was used in western blot to study the role of soluble total and hyperphosphorylated tau in brain pathology and behaviour in a transgenic mouse model
Wed Nov 13 00:00:00 UTC 2013
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.
Journal of neuropathology and experimental neurology
Hensley K,Gabbita SP,Venkova K,Hristov A,Johnson MF,Eslami P,Harris-White ME
MN1020B was used in immunohistochemistry to study the beneficial effects of a bioavailable ester of lanthione ketimine in respect of cognition and pathology in a murine model of Alzheimer's disease
Tue Oct 01 00:00:00 UTC 2013
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.
Journal of neuroscience methods
Feldengut S,Del Tredici K,Braak H
MN1020B was used in immunohistochemistry to report on the use of 70-100 micrometer paraffin sections for studying the nervous system
Wed May 15 00:00:00 UTC 2013
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
Brain and language
Josephs KA,Dickson DW,Murray ME,Senjem ML,Parisi JE,Petersen RC,Jack CR,Whitwell JL
MN1020B was used in immunohistochemistry to study grey matter volume and neurofibrilliary tangle density in Alzheimer's disease patients including those presenting with logopenic progressive aphasia
Fri Nov 01 00:00:00 UTC 2013
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
PloS one
Rantamäki T,Kemppainen S,Autio H,Stavén S,Koivisto H,Kojima M,Antila H,Miettinen PO,Kärkkäinen E,Karpova N,Vesa L,Lindemann L,Hoener MC,Tanila H,Castrén E
MN1020B was used in immunohistochemistry to study the effects of Bdnf gene deficiency on memory, behaviour and disease pathology in a murine Alzheimer's disease model
Fri Feb 07 00:00:00 UTC 2014
Ubiquilin 2 is not associated with tau pathology.
PloS one
Nölle A,van Haastert ES,Zwart R,Hoozemans JJ,Scheper W
MN1020B was used in immunohistochemistry to study the lack of association of ubiquilin-2 with tau pathology in Alzheimer's disease
Mon Jun 16 00:00:00 UTC 2014
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.
Age (Dordrecht, Netherlands)
Manaye KF,Mouton PR,Xu G,Drew A,Lei DL,Sharma Y,Rebeck GW,Turner S
MN1020B was used in immunocytochemistry to investigate the changes of TH+ neurons in an Alzheimer disease mouse model
Fri Feb 01 00:00:00 UTC 2013
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
The Journal of biological chemistry
Hawkins BE,Krishnamurthy S,Castillo-Carranza DL,Sengupta U,Prough DS,Jackson GR,DeWitt DS,Kayed R
MN1020B was used in ELISA, immunohistochemistry, and western blot to study the generation of oligomeric and phosphorylated forms of tau in a rat model of traumatic brain injury
Fri Jun 07 00:00:00 UTC 2013
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Acta neuropathologica communications
Hoffmann NA,Dorostkar MM,Blumenstock S,Goedert M,Herms J
MN1020B was used in immunohistochemistry to study the potential involvement of pre-fibrilliary tau in the defective plasticity of cortical dendritic spines observed in transgenic mice bearing the P301S tau mutation
Tue Dec 17 00:00:00 UTC 2013
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
PloS one
Ozcelik S,Fraser G,Castets P,Schaeffer V,Skachokova Z,Breu K,Clavaguera F,Sinnreich M,Kappos L,Goedert M,Tolnay M,Winkler DT
MN1020B was used in immunohistochemistry and western blot to study the protective effects of rapamycin against tau pathology in a murine transgenic model
Mon Dec 09 00:00:00 UTC 2013
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Acta neuropathologica communications
Trujillo-Estrada L,Jimenez S,De Castro V,Torres M,Baglietto-Vargas D,Moreno-Gonzalez I,Navarro V,Sanchez-Varo R,Sanchez-Mejias E,Davila JC,Vizuete M,Gutierrez A,Vitorica J
MN1020B was used in western blot to study the beneficial effects of lithium treatment on beta-amyloid neuropathology in a murine model of Alzheimer's disease
Tue Nov 12 00:00:00 UTC 2013
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Cell death & disease
Tackenberg C,Grinschgl S,Trutzel A,Santuccione AC,Frey MC,Konietzko U,Grimm J,Brandt R,Nitsch RM
MN1020B was used in western blot to study the effect of the subunit composition of NMDA receptors on neurodegeneration and synaptic loss induced by beta-amyloid
Thu Apr 25 00:00:00 UTC 2013
PINCH in the cellular stress response to tau-hyperphosphorylation.
PloS one
Ozdemir AY,Rom I,Kovalevich J,Yen W,Adiga R,Dave RS,Langford D
MN1020B was used in western blot to study the ability of PINCH in bind and stabilize hyperphoshorylated tau
Mon Sep 30 00:00:00 UTC 2013
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
The Journal of clinical investigation
Talbot K,Wang HY,Kazi H,Han LY,Bakshi KP,Stucky A,Fuino RL,Kawaguchi KR,Samoyedny AJ,Wilson RS,Arvanitakis Z,Schneider JA,Wolf BA,Bennett DA,Trojanowski JQ,Arnold SE
MN1020B was used in immunohistochemistry to study the role of IGF-1 and IRS-1 in brain insulin resistance and cognitive decline in Alzheimer's disease
Sun Apr 01 00:00:00 UTC 2012
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
The Journal of experimental medicine
Yao J,Ho D,Calingasan NY,Pipalia NH,Lin MT,Beal MF
MN1020B was used in immunohistochemistry to study the beneficial effects of hydroxy-beta-cyclodextrin on neuropathology and beta-amyloid levels in Alzheimer's disease models
Mon Dec 17 00:00:00 UTC 2012
Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.
Acta neuropathologica
Stefanits H,Budka H,Kovacs GG
MN1020B was used in immunohistochemistry to characterize Alzheimer disease associated pathology
Thu Mar 01 00:00:00 UTC 2012
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.
Acta neuropathologica
Okamoto Y,Yamamoto T,Kalaria RN,Senzaki H,Maki T,Hase Y,Kitamura A,Washida K,Yamada M,Ito H,Tomimoto H,Takahashi R,Ihara M
MN1020B was used in immunohistochemistry to investigate the effect of low cerebral perfusion on cerebral amyloid angiopathy
Thu Mar 01 00:00:00 UTC 2012
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.
Acta neuropathologica
Woehrer A,Laszlo L,Finsterer J,Stöllberger C,Furtner J,Rinner W,Molnar K,Budka H,Kovacs GG
MN1020B was used in immunohistochemistry to study crystalloid oligodendrogliopathy in hereditary spastic paraplegia
Mon Oct 01 00:00:00 UTC 2012
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Brain : a journal of neurology
Petratos S,Ozturk E,Azari MF,Kenny R,Lee JY,Magee KA,Harvey AR,McDonald C,Taghian K,Moussa L,Mun Aui P,Siatskas C,Litwak S,Fehlings MG,Strittmatter SM,Bernard CC
MN1020B was used in immunohistochemistry to study the effect of blocking the Nogo receptor and CRMP-2 phosphorylation on multiple sclerosis-related axonopathy
Fri Jun 01 00:00:00 UTC 2012
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
The Journal of pathology
Nijholt DA,van Haastert ES,Rozemuller AJ,Scheper W,Hoozemans JJ
MN1020B was used in immunohistochemistry to investigate the unfolded protein response in the hippocampus of tauopathies.
Sun Apr 01 00:00:00 UTC 2012
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
Journal of medicinal chemistry
Boländer A,Kieser D,Voss C,Bauer S,Schön C,Burgold S,Bittner T,Hölzer J,Heyny-von Haußen R,Mall G,Goetschy V,Czech C,Knust H,Berger R,Herms J,Hilger I,Schmidt B
MN1020B was used in immunohistochemistry to investigate the potential of fluorescent pyrazine, pyrimidine, and pyridazine derivatives for tau-based diagnosis of Alzhemer's disease
Thu Nov 08 00:00:00 UTC 2012
Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.
Brain pathology (Zurich, Switzerland)
Morawski M,Brückner G,Jäger C,Seeger G,Matthews RT,Arendt T
MN1020B was used in immunocytochemistry to investigate aggrecan-based perineuronal nets and brevican-based perisynaptic axonal coats in brains with amyloid plaques and neurofibrillary tangles
Sun Jul 01 00:00:00 UTC 2012
Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sundaram JR,Chan ES,Poore CP,Pareek TK,Cheong WF,Shui G,Tang N,Low CM,Wenk MR,Kesavapany S
MN1020B was used in immunohistochemistry to investigate the important roles of p25/Cdk5 in neuroinflammation and neurodegeneration
Wed Jan 18 00:00:00 UTC 2012
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang HY,Bakshi K,Frankfurt M,Stucky A,Goberdhan M,Shah SM,Burns LH
MN1020B was used in western blot to study the ability of a small molecule that binds filamin A with high affinity to reduce beta-amyloid-associated Alzheimer's disease pathology
Wed Jul 18 00:00:00 UTC 2012
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barten DM,Fanara P,Andorfer C,Hoque N,Wong PY,Husted KH,Cadelina GW,Decarr LB,Yang L,Liu V,Fessler C,Protassio J,Riff T,Turner H,Janus CG,Sankaranarayanan S,Polson C,Meredith JE,Gray G,Hanna A,Olson RE,Kim SH,Vite GD,Lee FY,Albright CF
MN1020B was used in immunohistochemistry to study the effects of a small molecule microtubule-stabilizer on microtubule hyperdynamics, cognitive performance and pathology in tau transgenic mice
Wed May 23 00:00:00 UTC 2012
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hong Y,Chan CB,Kwon IS,Li X,Song M,Lee HP,Liu X,Sompol P,Jin P,Lee HG,Yu SP,Ye K
MN1020B was used in immunohistochemistry to study the ability of the cell cycle-regulated kinase SRPK2 to phosphorylate tau and the significance for Alzheimer's disease cognitive decline
Wed Nov 28 00:00:00 UTC 2012
Hirano body-rich subtypes of Creutzfeldt-Jakob disease.
Neuropathology and applied neurobiology
Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R
MN1020B was used in immunohistochemistry to detect Hirano bodies in neurons of Creutzfeldt-Jakob disease
Sun Apr 01 00:00:00 UTC 2012
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
Neuropathology and applied neurobiology
Satoh J,Tabunoki H,Ishida T,Saito Y,Arima K
MN1020B was used in immunohistochemistry to investigate the changes of GSAP expression in Alzheimer disease patients
Sun Apr 01 00:00:00 UTC 2012
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lasagna-Reeves CA,Castillo-Carranza DL,Sengupta U,Sarmiento J,Troncoso J,Jackson GR,Kayed R
MN1020B was used in immunohistochemistry to investigate the important role of tau oligomers in Alzheimer disease brains
Tue May 01 00:00:00 UTC 2012
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
The American journal of pathology
Perez SE,Getova DP,He B,Counts SE,Geula C,Desire L,Coutadeur S,Peillon H,Ginsberg SD,Mufson EJ
MN1020B was used in immunohistochemistry to study the expression of Raclb in cholinergic nucleus basalis neurones and the correlation with tau pathology and Alzheimer's disease progression
Wed Feb 01 00:00:00 UTC 2012
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology
Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM
MN1020B was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model
Wed Aug 01 00:00:00 UTC 2012
(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.
European journal of pharmacology
Li L,Zhang ZF,Holscher C,Gao C,Jiang YH,Liu YZ
MN1020B was used in western blot to investigate the effect of glucagon-like peptide-1 on the Alzheimer disease phenotype induced by streptozotocin
Sun Jan 15 00:00:00 UTC 2012
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.
Neurobiology of aging
Gerhauser I,Wohlsein P,Ernst H,Germann PG,Baumgärtner W
MN1020B was used in immunohistochemistry to evaluate Syrian hamsters as a useful animal model for Alzheimer disease
Wed Aug 01 00:00:00 UTC 2012
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Neurobiology of aging
Sheppard O,Plattner F,Rubin A,Slender A,Linehan JM,Brandner S,Tybulewicz VL,Fisher EM,Wiseman FK
MN1020B was used in western blot to investigate the regulation of tau phosphorylation in Tc1 mice
Sun Apr 01 00:00:00 UTC 2012
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.
Neurobiology of aging
Orejana L,Barros-Miñones L,Jordán J,Puerta E,Aguirre N
MN1020B was used in western blot to determine effect of sildenafil on age-related neurodeneration
Thu Mar 01 00:00:00 UTC 2012
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
Neurobiology of aging
García-Mesa Y,Giménez-Llort L,López LC,Venegas C,Cristòfol R,Escames G,Acuña-Castroviejo D,Sanfeliu C
MN1020B was used in western blot to investigate the efficacy of exercise and melatonin in AD therapy
Fri Jun 01 00:00:00 UTC 2012
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Neurobiology of aging
Lee HJ,Lee JK,Lee H,Carter JE,Chang JW,Oh W,Yang YS,Suh JG,Lee BH,Jin HK,Bae JS
MN1020B was used in immunohistochemistry to investigate the efficiency of human umbilical cord blood-derived mesenchymal stem cell transplantation in mouse model
Thu Mar 01 00:00:00 UTC 2012
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Neurobiology of aging
Krüger U,Wang Y,Kumar S,Mandelkow EM
MN1020B was used in western blot to investigate the effect of trehalose on tau accumulation in AD patients
Mon Oct 01 00:00:00 UTC 2012
Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.
Neurobiology of aging
Kantarci K,Yang C,Schneider JA,Senjem ML,Reyes DA,Lowe VJ,Barnes LL,Aggarwal NT,Bennett DA,Smith GE,Petersen RC,Jack CR,Boeve BF
MN1020B was used in immunohistochemistry to study the association of beta-amyloid and lewy body in a clinical case of dementia
Tue May 01 00:00:00 UTC 2012
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Human molecular genetics
Dumont M,Stack C,Elipenahli C,Jainuddin S,Gerges M,Starkova N,Calingasan NY,Yang L,Tampellini D,Starkov AA,Chan RB,Di Paolo G,Pujol A,Beal MF
MN1020B was used in immunohistochemistry to study the effects of the pan-PPAR agonist bezafibrate on inflammation, behaviour and tau pathology in a murine model
Sat Dec 01 00:00:00 UTC 2012
Frontal cortex neuropathology in dementia pugilistica.
Journal of neurotrauma
Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E
MN1020B was used in immunohistochemistry to investigate the neuropathological changes in dementia pugilistica patients
Tue Apr 10 00:00:00 UTC 2012
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Molecular and cellular neurosciences
Khandelwal PJ,Dumanis SB,Herman AM,Rebeck GW,Moussa CE
MN1020B was used in western blot to investigate the effects of wild type and P301L mutant tau on neuro-inflammation and alpha-synuclein accumulation in a rat model
Sun Jan 01 00:00:00 UTC 2012
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Neurotoxicology
Rahman A,Khan KM,Al-Khaledi G,Khan I,Al-Shemary T
MN1020B was used in western blot to study the role of hippocampal PP1 and PP2A activation in the deleterious effects of lead on learning and memory in a rat model
Fri Jun 01 00:00:00 UTC 2012
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Journal of Alzheimer's disease : JAD
Cuadrado-Tejedor M,Ricobaraza A,Frechilla D,Franco R,Pérez-Mediavilla A,Garcia-Osta A
MN1020B was used in immunohistochemistry to investigate the role of chronic mild stress in the pathogenesis of Alzheimer disease
Fri Jun 15 00:00:00 UTC 2012
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Journal of Alzheimer's disease : JAD
Clausen A,Xu X,Bi X,Baudry M
MN1020B was used in immunohistochemistry to study the role of oxidative stress in Alzheimer's disease pathogenesis and progression
Mon Sep 10 00:00:00 UTC 2012
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Journal of Alzheimer's disease : JAD
Venkataramani V,Wirths O,Budka H,Härtig W,Kovacs GG,Bayer TA
MN1020B was used in immunohistochemistry to characterize a conformation-dependent amyloid beta monoclonal antibody
Thu Jul 26 00:00:00 UTC 2012
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Journal of Alzheimer's disease : JAD
Elipenahli C,Stack C,Jainuddin S,Gerges M,Yang L,Starkov A,Beal MF,Dumont M
MN1020B was used in immunohistochemistry to study the behavioral benefit of coenzyme Q10 in P301S transgenic mice
Wed Sep 12 00:00:00 UTC 2012
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.
Journal of Alzheimer's disease : JAD
Giustiniani J,Sineus M,Sardin E,Dounane O,Panchal M,Sazdovitch V,Duyckaerts C,Chambraud B,Baulieu EE
MN1020B was used in immunohistochemistry to investigate the change of the immunophilin FKBP52 in human brains of neurodegenerative diseases
Thu Jul 26 00:00:00 UTC 2012
Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.
Journal of Alzheimer's disease : JAD
Antonell A,Gelpi E,Sánchez-Valle R,Martínez R,Molinuevo JL,Lladó A
MN1020B was used in immunohistochemistry to analyze the breakpoint sequence of an APP locus duplication associated with autosomal dominant Alzheimer disease
Thu May 24 00:00:00 UTC 2012
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
FEBS letters
Yokota T,Akatsu H,Miyauchi T,Heese K
MN1020B was used in western blot to study the potential involvement of the novel P9TLDR protein in Alzheimer's disease
Fri Dec 14 00:00:00 UTC 2012
Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996)
Schauer TH,Lochner M,Kovacs GG
MN1020B was used in immunohistochemistry to study the lack of association between striatal dopamine deficit and nigral tau pathology and striatal amyloid-beta deposition
Sat Dec 01 00:00:00 UTC 2012
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Metabolic brain disease
Kapas I,Majtenyi K,Törö K,Keller E,Voigtländer T,Kovacs GG
MN1020B was used in immunohistochemistry to study pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease
Fri Jun 01 00:00:00 UTC 2012
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
Behavioural brain research
Mustroph ML,King MA,Klein RL,Ramirez JJ
MN1020B was used in immunohistochemistry to study the role of tauopathy on spatial working memory in a rat model
Sun Jul 15 00:00:00 UTC 2012
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
Neuroscience letters
van Abel D,Abdulhamid O,Scheper W,van Dijk M,Oudejans CB
MN1020B was used in western blot to study the induction of tau phosphorylation at sites hyperphosphorylated in Alzheimer's disease by over expression of the STOX1A transcription factor
Wed Oct 24 00:00:00 UTC 2012
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Journal of molecular neuroscience : MN
Löffler T,Flunkert S,Taub N,Schofield EL,Ward MA,Windisch M,Hutter-Paier B
MN1020B was used in western blot to develop a cell line stably expressing mutant tau441 for screening Alzheimer's disease drug candidates
Tue May 01 00:00:00 UTC 2012
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
Rodriguez-Diehl R,Rey MJ,Gironell A,Martinez-Saez E,Ferrer I,Sánchez-Valle R,Jagüe J,Nos C,Gelpi E
MN1020B was used in immunohistochemistry to report on a case of co-existing multiple system atrophy and Creutzfeldt-Jakob disease
Sun Apr 01 00:00:00 UTC 2012
Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.
Journal of comparative pathology
Piccardo P,Cervenak J,Yakovleva O,Gregori L,Pomeroy K,Cook A,Muhammad FS,Seuberlich T,Cervenakova L,Asher DM
MN1020B was used in immunohistochemistry to study the tau pathology in squirrel monkeys after infection with the agent of bovine spongiform encephalopathy
Sun Jul 01 00:00:00 UTC 2012
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Acta biologica Hungarica
Rahman A,Khan KM,Al-Khaledi G,Khan I,Attur S
MN1020B was used in western blot to study tau phosphorylation in response to early post-natal exposure to lead
Sat Dec 01 00:00:00 UTC 2012
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
PloS one
Herzig MC,Bidinosti M,Schweizer T,Hafner T,Stemmelen C,Weiss A,Danner S,Vidotto N,Stauffer D,Barske C,Mayer F,Schmid P,Rovelli G,van der Putten PH,Shimshek DR
MN1020B was used in western blot to study the effect of high LRRK2 levels on neuronal alpha-synucleinopathy in transgenic mice
Fri Sep 14 00:00:00 UTC 2012
Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.
PloS one
Capsoni S,Marinelli S,Ceci M,Vignone D,Amato G,Malerba F,Paoletti F,Meli G,Viegi A,Pavone F,Cattaneo A
MN1020B was used in immunohistochemistry to study the therapeutic effect of intranasal delivery of nerve growth factor in a modelof Alzheimer's disease
Mon Oct 29 00:00:00 UTC 2012
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Molecular neurodegeneration
Inoue K,Rispoli J,Kaphzan H,Klann E,Chen EI,Kim J,Komatsu M,Abeliovich A
MN1020B was used in immunohistochemistry to study the role of the phospho-Tau pathway in the mechanism by which deficient macroautophagy promotes age-related neurodegeneration
Fri Sep 21 00:00:00 UTC 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1020B was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 UTC 2012
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
The Journal of biological chemistry
Mondragón-Rodríguez S,Trillaud-Doppia E,Dudilot A,Bourgeois C,Lauzon M,Leclerc N,Boehm J
MN1020B was used in immunocytochemistry to study the role of NMDA receptor-dependent tau phosphorylation in modulating the interaction of endogenous tau with synaptic proteins
Fri Sep 14 00:00:00 UTC 2012
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
The Journal of biological chemistry
Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T
MN1020B was used in western blot to study the role of phosphorylation in the membrane-microdomain localization of amyloid ?-precursor protein C-terminal fragments
Fri Jun 01 00:00:00 UTC 2012
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
PloS one
Schön C,Hoffmann NA,Ochs SM,Burgold S,Filser S,Steinbach S,Seeliger MW,Arzberger T,Goedert M,Kretzschmar HA,Schmidt B,Herms J
MN1020B was used in immunohistochemistry to develop an imaging system for long-term monitoring of retinal fibrillar tau in P301S tau transgenic mice and to study whether retinal tau is diagnostic in Alzheimer's disease
Mon Jun 24 00:00:00 UTC 2013
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
PloS one
Harris JA,Koyama A,Maeda S,Ho K,Devidze N,Dubal DB,Yu GQ,Masliah E,Mucke L
MN1020B was used in immunohistochemistry to study whether tau pathology caused by overexpression of mutant P301L tau in the murine entorhinal-hippocampal network leads to cognitive defects
Thu Feb 28 00:00:00 UTC 2013
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Journal of neuroinflammation
Britschgi M,Takeda-Uchimura Y,Rockenstein E,Johns H,Masliah E,Wyss-Coray T
MN1020B was used in immunohistochemistry to study the potential role of the central and terminal complement pathways in tau neuropathology
Tue Sep 18 00:00:00 UTC 2012
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
PloS one
Julien C,Marcouiller F,Bretteville A,El Khoury NB,Baillargeon J,Hébert SS,Planel E
MN1020B was used in immunohistochemistry to study the ability of DMSO to directly and indirectly induce hyperphosphorylation of tau
Tue Nov 27 00:00:00 UTC 2012
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
PLoS genetics
Merkwirth C,Martinelli P,Korwitz A,Morbin M,Brönneke HS,Jordan SD,Rugarli EI,Langer T
MN1020B was used in immunohistochemistry to study tau hyperphosphorylation and neurodegeneration induced by loss of murine neuronal PHB2
Mon May 13 00:00:00 UTC 2013
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Molecular neurodegeneration
Torres M,Jimenez S,Sanchez-Varo R,Navarro V,Trujillo-Estrada L,Sanchez-Mejias E,Carmona I,Davila JC,Vizuete M,Gutierrez A,Vitorica J
MN1020B was used in immunohistochemistry and western blot to study elevated APP metabolism and synaptic beta-amyloid accumulation in a murine transgenic model of Alzheimer's disease and the roles of axonal dystrophy and impaired lysosomal proteolysis
Thu Nov 22 00:00:00 UTC 2012
Microglial pathology in Down syndrome.
Acta neuropathologica
Xue QS,Streit WJ
MN1020B was used in immunohistochemistry to investigate the changes of microglial cells in Down syndrome patients
Sat Oct 01 00:00:00 UTC 2011
The pathological process underlying Alzheimer's disease in individuals under thirty.
Acta neuropathologica
Braak H,Del Tredici K
MN1020B was used in immunocytochemistry to investigate the changes of gene expression in young Alzheimer disease patients
Tue Feb 01 00:00:00 UTC 2011
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
The EMBO journal
Li X,Kumar Y,Zempel H,Mandelkow EM,Biernat J,Mandelkow E
MN1020B was used in western blot to investigate the mechanism for the tau missorting in Alzheimer disease
Tue Oct 18 00:00:00 UTC 2011
Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.
Biological psychiatry
Engmann O,Hortobágyi T,Thompson AJ,Guadagno J,Troakes C,Soriano S,Al-Sarraj S,Kim Y,Giese KP
MN1020B was used in immunohistochemistry to study the generation of the p25 Cdk5 activator during spatial memory formation and its reduction in early stage Alzheimer's disease
Fri Jul 15 00:00:00 UTC 2011
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Annals of neurology
Green KN,Khashwji H,Estrada T,Laferla FM
MN1020B was used in western blot to investigate the effect of ZSET 1446 on APP digestion in vivo
Sun May 01 00:00:00 UTC 2011
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Annals of neurology
Jayadev S,Nochlin D,Poorkaj P,Steinbart EJ,Mastrianni JA,Montine TJ,Ghetti B,Schellenberg GD,Bird TD,Leverenz JB
MN1020B was used in immunohistochemistry to study the Alzheimer disease-like clinical features and tau pathology in a familial prion disease
Fri Apr 01 00:00:00 UTC 2011
Rapidly progressive diffuse Lewy body disease.
Movement disorders : official journal of the Movement Disorder Society
Gaig C,Valldeoriola F,Gelpi E,Ezquerra M,Llufriu S,Buongiorno M,Rey MJ,Martí MJ,Graus F,Tolosa E
MN1020B was used in immunohistochemistry to evaluate clinical and neuropathological features of patients with a rapidly progressive diffuse Lewy body disease
Wed Jun 01 00:00:00 UTC 2011
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.
British journal of pharmacology
Cuadrado-Tejedor M,Hervias I,Ricobaraza A,Puerta E,Pérez-Roldán JM,García-Barroso C,Franco R,Aguirre N,García-Osta A
MN1020B was used in western blot to study the effect of sildenafil on neuroplasticity related to Alzheimer
Thu Dec 01 00:00:00 UTC 2011
WNT signaling in activated microglia is proinflammatory.
Glia
Halleskog C,Mulder J,Dahlström J,Mackie K,Hortobágyi T,Tanila H,Kumar Puli L,Färber K,Harkany T,Schulte G
MN1020B was used in immunohistochemistry to study the involvement of WNT signaling in inflammatory response in microglia
Sat Jan 01 00:00:00 UTC 2011
Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.
Brain pathology (Zurich, Switzerland)
Hagen MC,Murrell JR,Delisle MB,Andermann E,Andermann F,Guiot MC,Ghetti B
MN1020B was used in immunohistochemistry to investigate the role of PI12 mutation on neuronal pathologenesis
Thu Sep 01 00:00:00 UTC 2011
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Verhaar R,Andringa G,Bol JG,Cras P,Shan L,Hoozemans JJ,Drukarch B
MN1020B was used in immunohistochemistry to study the presence of tissue transglutaminase in melanized neurons in Parkinson's disease brain
Tue Mar 01 00:00:00 UTC 2011
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Brain pathology (Zurich, Switzerland)
Sepulveda-Falla D,Matschke J,Bernreuther C,Hagel C,Puig B,Villegas A,Garcia G,Zea J,Gomez-Mancilla B,Ferrer I,Lopera F,Glatzel M
MN1020B was used in immunohistochemistry to investigate the distribution of phosphorylated tau in Alzheimer disease patients
Fri Jul 01 00:00:00 UTC 2011
Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510).
NeuroImage
Yang D,Xie Z,Stephenson D,Morton D,Hicks CD,Brown TM,Sriram R,O'Neill S,Raunig D,Bocan T
MN1020B was used in immunohistochemistry to evaluate the MRI and MRS for the detection of brain changes in Tau transgenic mice
Mon Feb 14 00:00:00 UTC 2011
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Neurobiology of disease
Nunes A,Pressey SN,Cooper JD,Soriano S
MN1020B was used in western blot to study the status of amyloid precursor protein in a Niemann-Pick type C disease mouse model and its effect on tau homeostasis
Wed Jun 01 00:00:00 UTC 2011
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Neurobiology of disease
Belarbi K,Burnouf S,Fernandez-Gomez FJ,Laurent C,Lestavel S,Figeac M,Sultan A,Troquier L,Leboucher A,Caillierez R,Grosjean ME,Demeyer D,Obriot H,Brion I,Barbot B,Galas MC,Staels B,Humez S,Sergeant N,Schraen-Maschke S,Muhr-Tailleux A,Hamdane M,Buée L,Blum D
MN1020B was used in immunohistochemistry to investigate the influence of long-term voluntary exercise on a transgenic mouse model of Tau pathology
Mon Aug 01 00:00:00 UTC 2011
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
Neurobiology of disease
Perez SE,He B,Muhammad N,Oh KJ,Fahnestock M,Ikonomovic MD,Mufson EJ
MN1020B was used in immunohistochemistry to investigate the changes of cholinotrophic system in Alzheimer disease mouse model
Tue Feb 01 00:00:00 UTC 2011
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kanaan NM,Morfini GA,LaPointe NE,Pigino GF,Patterson KR,Song Y,Andreadis A,Fu Y,Brady ST,Binder LI
MN1020B was used in immunohistochemistry to investigate the inhibitory effect of pathogenic forms of tau on anterograde fast axonal transport
Wed Jul 06 00:00:00 UTC 2011
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shipton OA,Leitz JR,Dworzak J,Acton CE,Tunbridge EM,Denk F,Dawson HN,Vitek MP,Wade-Martins R,Paulsen O,Vargas-Caballero M
MN1020B was used in western blot to study the role of Abeta in Tau phosphorylation and its mechanism
Wed Feb 02 00:00:00 UTC 2011
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Maeda J,Zhang MR,Okauchi T,Ji B,Ono M,Hattori S,Kumata K,Iwata N,Saido TC,Trojanowski JQ,Lee VM,Staufenbiel M,Tomiyama T,Mori H,Fukumura T,Suhara T,Higuchi M
MN1020B was used in immunohistochemistry to investigate the association of TSPO expression with pathology of Alzheimer disease
Wed Mar 23 00:00:00 UTC 2011
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sydow A,Van der Jeugd A,Zheng F,Ahmed T,Balschun D,Petrova O,Drexler D,Zhou L,Rune G,Mandelkow E,D'Hooge R,Alzheimer C,Mandelkow EM
MN1020B was used in immunohistochemistry to investigate the effect of Tau mutations on the behavior and electrophysiology of mice
Wed Feb 16 00:00:00 UTC 2011
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.
Molecular medicine (Cambridge, Mass.)
Ferreira A,Bigio EH
MN1020B was used in western blot to investigate tau cleavage mediated by calpain and its relationship with tau aggregation in tauopathies
Tue Dec 27 00:00:00 UTC 2011
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dumont M,Stack C,Elipenahli C,Jainuddin S,Gerges M,Starkova NN,Yang L,Starkov AA,Beal F
MN1020B was used in western blot to determine the role of oxidative stress in neurodegenerative disease progression
Tue Nov 01 00:00:00 UTC 2011
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
The American journal of pathology
Wilhelmus MM,Bol JG,Van Haastert ES,Rozemuller AJ,Bu G,Drukarch B,Hoozemans JJ
MN1020B was used in immunohistochemistry to study the potential roles of ApoE1 and LRP1 in the pathogenesis of Parkinson's disease
Tue Nov 01 00:00:00 UTC 2011
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Disease models & mechanisms
Copenhaver PF,Anekonda TS,Musashe D,Robinson KM,Ramaker JM,Swanson TL,Wadsworth TL,Kretzschmar D,Woltjer RL,Quinn JF
MN1020B was used in western blot to study the role of calcium homeostasis in Alzheimer disease using four model systems
Thu Sep 01 00:00:00 UTC 2011
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Laboratory investigation; a journal of technical methods and pathology
Castellani RJ,Gupta Y,Sheng B,Siedlak SL,Harris PL,Coller JM,Perry G,Lee HG,Tabaton M,Smith MA,Wang X,Zhu X
MN1020B was used in immunohistochemistry to study the phosphorylated ribosomal protein S6 in aging and Alzheimer disease
Thu Dec 01 00:00:00 UTC 2011
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Neurobiology of aging
Whitwell JL,Jack CR,Przybelski SA,Parisi JE,Senjem ML,Boeve BF,Knopman DS,Petersen RC,Dickson DW,Josephs KA
MN1020B was used in immunohistochemistry to study the temporoparietal atrophy in patients with Alzheimer disease
Thu Sep 01 00:00:00 UTC 2011
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
Human molecular genetics
Ambegaokar SS,Jackson GR
MN1020B was used in western blot to identify modifiers of tau toxicity and their relationships with tau phosphorylation state
Thu Dec 15 00:00:00 UTC 2011
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.
Journal of hypertension
Goodwin JE,Zhang J,Gonzalez D,Albinsson S,Geller DS
MN1020B was used in immunocytochemistry to investigate the role of the vasculature in the generation and maintenance of glucocorticoid-mediated hypertension
Fri Jul 01 00:00:00 UTC 2011
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Neurochemistry international
Alonso E,Vale C,Vieytes MR,Laferla FM,Giménez-Llort L,Botana LM
MN1020B was used in western blot to investigate the effect of 13-desmethyl spirolide-C on both tau and beta-amyloid peptide
Thu Dec 01 00:00:00 UTC 2011
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
Journal of Alzheimer's disease : JAD
Silva DF,Esteves AR,Arduino DM,Oliveira CR,Cardoso SM
MN1020B was used in western blot to investigate the impairment of autophagic lysosomal pathway caused by amyloid-beta-induced mitochondrial dysfunction
Wed Jan 11 00:00:00 UTC 2012
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Journal of neural transmission (Vienna, Austria : 1996)
Seilhean D,Le Ber I,Sarazin M,Lacomblez L,Millecamps S,Salachas F,Pradat PF,Le Forestier N,LeGuern E,Dubois B,Meininger V,Brice A,Hauw JJ,Duyckaerts C
MN1020B was used in immunohistochemistry to investigate the neuropathology of fronto-temporal lobar degeneration patients
Sun May 01 00:00:00 UTC 2011
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.
Journal of neural transmission (Vienna, Austria : 1996)
Braak H,Thal DR,Del Tredici K
MN1020B was used in immunohistochemistry to investigate the localization of p62 in specific brain regions of Parkinson disease patients
Sun May 01 00:00:00 UTC 2011
Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors.
The European journal of neuroscience
Roe AD,Staup MA,Serrats J,Sawchenko PE,Rissman RA
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Aug 01 00:00:00 UTC 2011
Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors.
The European journal of neuroscience
Roe AD,Staup MA,Serrats J,Sawchenko PE,Rissman RA
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunohistochemistry
Mon Aug 01 00:00:00 UTC 2011
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Behavioural brain research
Ramirez JJ,Poulton WE,Knelson E,Barton C,King MA,Klein RL
MN1020B was used in immunohistochemistry to investigate the phenotypes of rats with overexpression of P301L tau in entorhinal cortex
Sat Jan 01 00:00:00 UTC 2011
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Neuroscience letters
Ringman JM,Gylys KH,Medina LD,Fox M,Kepe V,Flores DL,Apostolova LG,Barrio JR,Small G,Silverman DH,Siu E,Cederbaum S,Hecimovic S,Malnar M,Chakraverty S,Goate AM,Bird TD,Leverenz JB
MN1020B was used in immunohistochemistry to characterize the effects of a novel presenilin 1 mutation in early-onset Alzheimer disease
Mon Jan 10 00:00:00 UTC 2011
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Neuroscience letters
Koike MA,Garcia FG,Kitazawa M,Green KN,Laferla FM
MN1020B was used in western blot to investigate the phosphorylation and aggregation of tau protein in the 3xTg-AD mice
Mon May 09 00:00:00 UTC 2011
Protein aggregation in the aging retina.
Journal of neuropathology and experimental neurology
Leger F,Fernagut PO,Canron MH,Léoni S,Vital C,Tison F,Bezard E,Vital A
MN1020B was used in immunohistochemistry to study the age-related protein aggregation in retina
Sat Jan 01 00:00:00 UTC 2011
Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.
Journal of neuropathology and experimental neurology
Panaite PA,Kielar M,Kraftsik R,Gourdon G,Kuntzer T,Barakat-Walter I
MN1020B was used in immunohistochemistry to investigate the role of peripheral neuropathy in myotonic dystrophy
Mon Aug 01 00:00:00 UTC 2011
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Journal of neuropathology and experimental neurology
Stone JG,Siedlak SL,Tabaton M,Hirano A,Castellani RJ,Santocanale C,Perry G,Smith MA,Zhu X,Lee HG
MN1020B was used in immunohistochemistry to investigate the association of phosphorylated Rb with hyperphosphorylated tau in distinct neurodegenerative diseases
Fri Jul 01 00:00:00 UTC 2011
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.
Journal of neuropathology and experimental neurology
Braak H,Thal DR,Ghebremedhin E,Del Tredici K
MN1020B was used in immunohistochemistry to investigate the progression of Alzheimer disease and the association between tauopathy and Alzheimer disease
Tue Nov 01 00:00:00 UTC 2011
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
Journal of neuropathology and experimental neurology
McMillan PJ,Kraemer BC,Robinson L,Leverenz JB,Raskind M,Schellenberg G
MN1020B was used in immunohistochemistry to investigate the role of a truncated tau in Alzheimer disease pathogenesis in mice
Tue Nov 01 00:00:00 UTC 2011
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.
Journal of neuropathology and experimental neurology
Glöckner F,Meske V,Lütjohann D,Ohm TG
MN1020B was used in immunohistochemistry to investigate the effect of dietary cholesterol on phosphorylation and aggregation of tau protein
Fri Apr 01 00:00:00 UTC 2011
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Journal of molecular neuroscience : MN
Currais A,Kato K,Canuet L,Ishii R,Tanaka T,Takeda M,Soriano S
MN1020B was used in western blot to investigate the effect of caffeine on tau phosphorylation and Akt signaling
Tue Mar 01 00:00:00 UTC 2011
αB-crystallin negative astrocytic inclusions.
Brain & development
Barnett BP,Bressler J,Chen T,Hutchins GM,Crain BJ,Kaufmann WE
MN1020B was used in immunohistochemistry to describe the pathology of astrocyte inclusions.
Fri Apr 01 00:00:00 UTC 2011
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Neuropathology : official journal of the Japanese Society of Neuropathology
Takahashi RH,Tobiume M,Sato Y,Sata T,Gouras GK,Takahashi H
MN1020B was used in immunocytochemistry to study the prion protein accumulation in the Alzheimer disease brain
Wed Jun 01 00:00:00 UTC 2011
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Journal of neuroinflammation
Fonseca MI,Chu SH,Berci AM,Benoit ME,Peters DG,Kimura Y,Tenner AJ
MN1020B was used in immunohistochemistry to investigate the role of complement activation pathways in Alzheimer disease
Sat Jan 15 00:00:00 UTC 2011
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
BMC neurology
Rusina R,Kovacs GG,Fiala J,Hort J,Ridzoň P,Holmerová I,Ströbel T,Matěj R
MN1020B was used in immunohistochemistry to investigate the different phenotypes of TDP-43 proteinopathies
Tue May 10 00:00:00 UTC 2011
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
The Journal of biological chemistry
Cho SH,Sun B,Zhou Y,Kauppinen TM,Halabisky B,Wes P,Ransohoff RM,Gan L
MN1020B was used in western blot to study the role of CX3CR1 protein in microglial activation and cognitive deficits in Alzheimer disease mouse model
Fri Sep 16 00:00:00 UTC 2011
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
PloS one
Talbot K,Louneva N,Cohen JW,Kazi H,Blake DJ,Arnold SE
MN1020B was used in immunohistochemistry to investigate the changes of dysbindin-1 in schizophrenia patients
Tue Mar 01 00:00:00 UTC 2011
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
The Journal of biological chemistry
Ando K,Uemura K,Kuzuya A,Maesako M,Asada-Utsugi M,Kubota M,Aoyagi N,Yoshioka K,Okawa K,Inoue H,Kawamata J,Shimohama S,Arai T,Takahashi R,Kinoshita A
MN1020B was used in western blot to investigate the role of N-cadherin dysfunction in Alzheimer disease pathogenesis
Fri Mar 04 00:00:00 UTC 2011
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
International journal of Alzheimer's disease
Sparks DL,Ziolkowski C,Lawmaster T,Martin T
MN1020B was used in immunohistochemistry to investigate the effect of water quality on tau pathology induced by cholesterol in a rabbit model
Sun Apr 17 00:00:00 UTC 2011
Propofol directly increases tau phosphorylation.
PloS one
Whittington RA,Virág L,Marcouiller F,Papon MA,El Khoury NB,Julien C,Morin F,Emala CW,Planel E
MN1020B was used in immunocytochemistry to study the effect of propofol on tau phosphorylation
Mon Jan 31 00:00:00 UTC 2011
A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death.
International journal of Alzheimer's disease
Li L,Cheung T,Chen J,Herrup K
MN1020B was used in immunohistochemistry to study five mouse models of Alzheimer's disease that may represent different disease phenotypes
Thu Nov 10 00:00:00 UTC 2011
Caspase activation precedes and leads to tangles.
Nature
de Calignon A,Fox LM,Pitstick R,Carlson GA,Bacskai BJ,Spires-Jones TL,Hyman BT
MN1020B was used in immunohistochemistry to investigate the effect of caspase activation on tangle formation
Thu Apr 22 00:00:00 UTC 2010
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neuron
Min SW,Cho SH,Zhou Y,Schroeder S,Haroutunian V,Seeley WW,Huang EJ,Shen Y,Masliah E,Mukherjee C,Meyers D,Cole PA,Ott M,Gan L
MN1020B was used in western blot to investigate the effect of tau modification on its stability and function in neurons
Thu Sep 23 00:00:00 UTC 2010
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Acta neuropathologica
Blanchard J,Wanka L,Tung YC,Cárdenas-Aguayo Mdel C,LaFerla FM,Iqbal K,Grundke-Iqbal I
MN1020B was used in immunohistochemistry to study the therapeutic enhancement of neuronal generation and plasticity in a model of Alzheimer's disease.
Mon Nov 01 00:00:00 UTC 2010
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.
Acta neuropathologica
Braak H,Ludolph A,Thal DR,Del Tredici K
MN1020B was used in immunohistochemistry to study the phosphorylation and accumulation of TDP-43 in brainstem and spinal cord in amyotrophic lateral sclerosis
Thu Jul 01 00:00:00 UTC 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.
Acta neuropathologica
Del Tredici K,Hawkes CH,Ghebremedhin E,Braak H
MN1020B was used in immunohistochemistry to investigate the submandibular gland of patients with Parkinson disease, incidental Lewy body disease, and multiple system atrophy
Tue Jun 01 00:00:00 UTC 2010
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Acta neuropathologica
Bigio EH,Mishra M,Hatanpaa KJ,White CL,Johnson N,Rademaker A,Weitner BB,Deng HX,Dubner SD,Weintraub S,Mesulam M
MN1020B was used in immunohistochemistry to study the pathology of TDP-43 in primary progressive aphasia and frontotemporal dementia
Thu Jul 01 00:00:00 UTC 2010
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Brain : a journal of neurology
Loy CT,McCusker E,Kril JJ,Kwok JB,Brooks WS,McCann H,Isaacs AM,Halliday GM
MN1020B was used in immunohistochemistry to study the pathological manifestation of very early-onset frontotemporal dementia
Wed Dec 01 00:00:00 UTC 2010
Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.
Journal of neurology, neurosurgery, and psychiatry
Pretnar-Oblak J,Zaletel M,Hajnsek TM,Meglic B,Hocevar-Boltezar I,Popovic M
MN1020B was used in immunohistochemistry to report a clinical case of medullar tau pathology with isolated bulbar paralysis
Sun Aug 01 00:00:00 UTC 2010
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Proceedings of the National Academy of Sciences of the United States of America
van Eersel J,Ke YD,Liu X,Delerue F,Kril JJ,Götz J,Ittner LM
MN1020B was used in western blot to investigate the effect of sodium selenate on tau pathology
Tue Aug 03 00:00:00 UTC 2010
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
Experimental & molecular medicine
Lee JH,Won SM,Suh J,Son SJ,Moon GJ,Park UJ,Gwag BJ
MN1020B was used in immunohistochemistry to examine the correlation between induction of the unfolded protein response and neurofibrillary tangle
Mon May 31 00:00:00 UTC 2010
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Stroke
Van Nostrand WE,Xu F,Rozemuller AJ,Colton CA
MN1020B was used in immunohistochemistry to study cerebral amyloid angiopathy in mice lacking nitric oxide synthase-2.
Fri Oct 01 00:00:00 UTC 2010
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Movement disorders : official journal of the Movement Disorder Society
Josephs KA,Whitwell JL,Boeve BF,Knopman DS,Petersen RC,Hu WT,Parisi JE,Dickson DW,Jack CR
MN1020B was used in immunohistochemistry to compare the gross pathology between CBS-corticobasal degeneration and CBS-Alzheimer disease
Thu Jul 15 00:00:00 UTC 2010
Hyposmia in progressive supranuclear palsy.
Movement disorders : official journal of the Movement Disorder Society
Silveira-Moriyama L,Hughes G,Church A,Ayling H,Williams DR,Petrie A,Holton J,Revesz T,Kingsbury A,Morris HR,Burn DJ,Lees AJ
MN1020B was used in immunohistochemistry to investigate the changes of smell capability in progressive supranuclear palsy
Thu Apr 15 00:00:00 UTC 2010
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Movement disorders : official journal of the Movement Disorder Society
Poorkaj P,Raskind WH,Leverenz JB,Matsushita M,Zabetian CP,Samii A,Kim S,Gazi N,Nutt JG,Wolff J,Yearout D,Greenup JL,Steinbart EJ,Bird TD
MN1020B was used in immunohistochemistry to identify the locus associated with parkinsonian syndromes
Fri Jul 30 00:00:00 UTC 2010
Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Escribano L,Simón AM,Gimeno E,Cuadrado-Tejedor M,López de Maturana R,García-Osta A,Ricobaraza A,Pérez-Mediavilla A,Del Río J,Frechilla D
MN1020B was used in immunohistochemistry to investigate the effect of rosiglitazone on memory rescue in Alzheimer disease patients and its mechanism
Tue Jun 01 00:00:00 UTC 2010
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Glia
Höftberger R,Fink S,Aboul-Enein F,Botond G,Olah J,Berki T,Ovadi J,Lassmann H,Budka H,Kovacs GG
MN1020B was used in immunohistochemistry to investigate the expression tubulin polymerization promoting protein in oligodendrocytes in multiple sclerosis
Mon Nov 15 00:00:00 UTC 2010
Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy.
Brain pathology (Zurich, Switzerland)
Soontornniyomkij V,Lynch MD,Mermash S,Pomakian J,Badkoobehi H,Clare R,Vinters HV
MN1020B was used in immunohistochemistry to investigate the association of cerebral microinfarcts with severe cerebral beta-amyloid angiopathy
Mon Mar 01 00:00:00 UTC 2010
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
Neurobiology of disease
van Bebber F,Paquet D,Hruscha A,Schmid B,Haass C
MN1020B was used in immunohistochemistry to investigate the non-effectiveness of methylene blue on tau function and polyglutamine toxicity in zebrafish
Wed Sep 01 00:00:00 UTC 2010
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peethumnongsin E,Yang L,Kallhoff-Muñoz V,Hu L,Takashima A,Pautler RG,Zheng H
MN1020B was used in western blot to investigate the interaction between presenilin- and tau-mediated pathways
Wed Oct 06 00:00:00 UTC 2010
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Andrews-Zwilling Y,Bien-Ly N,Xu Q,Li G,Bernardo A,Yoon SY,Zwilling D,Yan TX,Chen L,Huang Y
MN1020B was used in immunohistochemistry to study the effect of apoE4 on GABAergic interneurons and its role in learning and memory deficits in mice
Wed Oct 13 00:00:00 UTC 2010
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Boutajangout A,Quartermain D,Sigurdsson EM
MN1020B was used in immunohistochemistry to investigate the effect of immunotherapy on cognitive decline in mouse
Wed Dec 08 00:00:00 UTC 2010
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tamayev R,Giliberto L,Li W,d'Abramo C,Arancio O,Vidal R,D'Adamio L
MN1020B was used in immunohistochemistry to investigate the influence of BRI2 mutation on learning and memory in mice
Wed Nov 03 00:00:00 UTC 2010
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
Neuropathology and applied neurobiology
Bhaskar K,Hobbs GA,Yen SH,Lee G
MN1020B was used in immunohistochemistry to compare the temporal and spatial distribution of Tyr18-phosphorylated tau with that of Ser202/Thr205-phosphorylated tau in the JNPL3 mouse model
Fri Oct 01 00:00:00 UTC 2010
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Neuropathology and applied neurobiology
Simpson JE,Ince PG,Haynes LJ,Theaker R,Gelsthorpe C,Baxter L,Forster G,Lace GL,Shaw PJ,Matthews FE,Savva GM,Brayne C,Wharton SB
MN1020B was used in immunohistochemistry to address the relationship of between astrocytic DNA damage response and Alzheimer pathology
Mon Feb 01 00:00:00 UTC 2010
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Stem cells (Dayton, Ohio)
Lee JK,Jin HK,Endo S,Schuchman EH,Carter JE,Bae JS
MN1020B was used in immunohistochemistry to evaluate bone marrow-derived mesenchymal stem cells as potential cellular therapy for Alzheimer disease
Mon Feb 01 00:00:00 UTC 2010
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology
Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM
MN1020B was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice
Mon Feb 01 00:00:00 UTC 2010
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology
Koike MA,Green KN,Blurton-Jones M,Laferla FM
MN1020B was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice
Thu Jul 01 00:00:00 UTC 2010
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
The American journal of pathology
Lee S,Varvel NH,Konerth ME,Xu G,Cardona AE,Ransohoff RM,Lamb BT
MN1020B was used in immunohistochemistry to investigate the influence of CX3CR1 deletion on A-beta accumulation in Alzheimer disease models
Mon Nov 01 00:00:00 UTC 2010
Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.
Neurobiology of aging
Khan TK,Alkon DL
MN1020B was used in immunohistochemistry to evaluate an approach for the early diagnostic of Alzheimer disease
Tue Jun 01 00:00:00 UTC 2010
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Endocrinology
Carroll JC,Rosario ER,Villamagna A,Pike CJ
MN1020B was used in immunohistochemistry to determine the effects of continuous and cyclic P4 treatments on levels of tau hyperphosphorylation
Tue Jun 01 00:00:00 UTC 2010
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.
Genetics
Ambegaokar SS,Jackson GR
MN1020B was used in western blot to study the interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila
Wed Sep 01 00:00:00 UTC 2010
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Journal of Alzheimer's disease : JAD
Liu XA,Liao K,Liu R,Wang HH,Zhang Y,Zhang Q,Wang Q,Li HL,Tian Q,Wang JZ
MN1020B was used in western blot to study the mechanism by which tau dephosphorylation facilitates apoptosis
Wed May 05 00:00:00 UTC 2010
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Greco SJ,Bryan KJ,Sarkar S,Zhu X,Smith MA,Ashford JW,Johnston JM,Tezapsidis N,Casadesus G
MN1020B was used in western blot to investigate the effect of leptin treatment on histopathology and memory capability in Alzheimer disease model
Thu Jul 22 00:00:00 UTC 2010
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD
Parachikova A,Vasilevko V,Cribbs DH,LaFerla FM,Green KN
MN1020B was used in western blot to investigate the effect of minocycline on endogenous neuroinflammation and tau modification in Alzheimer disease mouse model
Mon Dec 20 00:00:00 UTC 2010
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.
Journal of Alzheimer's disease : JAD
Chen X,Wagener JF,Morgan DH,Hui L,Ghribi O,Geiger JD
MN1020B was used in immunohistochemistry to study the role of elevated cholesterol ingestion on the pathology of Alzheimer's disease.
Wed May 25 00:00:00 UTC 2011
Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.
Brain structure & function
Dickstein DL,Brautigam H,Stockton SD,Schmeidler J,Hof PR
MN1020B was used in immunocytochemistry to investigate the alterations in dendrites and spines in the transgenic mice with human wild-type tau
Mon Mar 01 00:00:00 UTC 2010
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Neuroscience
Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V
MN1020B was used in immunohistochemistry to study the effect of caprospinol on amyloid deposits and cognitive function in a rodent Alzheimer disease model
Wed Jan 20 00:00:00 UTC 2010
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.
Neuroscience
Morawski M,Brückner G,Jäger C,Seeger G,Arendt T
MN1020B was used in immunohistochemistry to investigate the effect of aggrecan-based extracellular matrix on neuroprotection in Alzheimer disease
Wed Sep 01 00:00:00 UTC 2010
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Neuroscience
Bertrand J,Plouffe V,Sénéchal P,Leclerc N
MN1020B was used in western blot to study the relationship between Tau phosphorylation pattern and neurodegenerative diseases
Wed Jun 30 00:00:00 UTC 2010
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
The European journal of neuroscience
Härtig W,Kacza J,Paulke BR,Grosche J,Bauer U,Hoffmann A,Elsinghorst PW,Gütschow M
MN1020B was used in immunohistochemistry to evaluate nanoparticles as carriers of AChE inhibitors for the treatment of Alzheimer disease
Fri Jan 01 00:00:00 UTC 2010
Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.
Brain research
Rosario ER,Carroll J,Pike CJ
MN1020B was used in immunohistochemistry to investigate the mechanism for the testosterone effect on Alzheimer disease-related pathology
Thu Nov 04 00:00:00 UTC 2010
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Brain research
Nicholson RM,Kusne Y,Nowak LA,LaFerla FM,Reiman EM,Valla J
MN1020B was used in immunohistochemistry to study areas of common vulnerability in different mouse models of Alzheimer's disease
Fri Aug 06 00:00:00 UTC 2010
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Brain research
Feuillette S,Deramecourt V,Laquerriere A,Duyckaerts C,Delisle MB,Maurage CA,Blum D,Buée L,Frébourg T,Campion D,Lecourtois M
MN1020B was used in immunohistochemistry to study the colocalization of filamin-A and myosin VI with fibrillary tau protein in neurodegenerative diseases
Fri Jul 23 00:00:00 UTC 2010
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.
Journal of neuropathology and experimental neurology
Caltagarone J,Hamilton RL,Murdoch G,Jing Z,DeFranco DB,Bowser R
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunofluorescence
Thu Apr 01 00:00:00 UTC 2010
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.
Journal of neuropathology and experimental neurology
Caltagarone J,Hamilton RL,Murdoch G,Jing Z,DeFranco DB,Bowser R
Published figure using Phospho-Tau (Ser202, Thr205) monoclonal antibody (Product # MN1020B) in Immunofluorescence
Thu Apr 01 00:00:00 UTC 2010
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Journal of neuropathology and experimental neurology
Mohorko N,Repovs G,Popović M,Kovacs GG,Bresjanac M
MN1020B was used in immunohistochemistry to detect neuronal fibrillar tau inclusions in human brain
Thu Apr 01 00:00:00 UTC 2010
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Journal of neuropathology and experimental neurology
McKee AC,Gavett BE,Stern RA,Nowinski CJ,Cantu RC,Kowall NW,Perl DP,Hedley-Whyte ET,Price B,Sullivan C,Morin P,Lee HS,Kubilus CA,Daneshvar DH,Wulff M,Budson AE
MN1020B was used in immunohistochemistry to study the mechanism for amyotrophic lateral sclerosis from head injury
Wed Sep 01 00:00:00 UTC 2010
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Heath JE,Siedlak SL,Zhu X,Lee HG,Thakur A,Yan R,Perry G,Smith MA,Castellani RJ
MN1020B was used in immunohistochemistry to investigate the distribution of membrane bound Reticulon proteins in neurodegenerative diseases
Wed Dec 01 00:00:00 UTC 2010
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Journal of comparative pathology
Capucchio MT,Márquez M,Pregel P,Foradada L,Bravo M,Mattutino G,Torre C,Schiffer D,Catalano D,Valenza F,Guarda F,Pumarola M
MN1020B was used in immunohistochemistry to investigate the lesions of parenchyma and vasculum in ageing equine brains with histological and immunohistochemical methods
Fri Jan 01 00:00:00 UTC 2010
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
The Journal of biological chemistry
Zheng YL,Amin ND,Hu YF,Rudrabhatla P,Shukla V,Kanungo J,Kesavapany S,Grant P,Albers W,Pant HC
MN1020B was used in western blot to investigate the effect of a p35 fragment on Cdk5-p25 activity and tau hyperphosphorylation
Fri Oct 29 00:00:00 UTC 2010
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
PloS one
Kakefuda K,Oyagi A,Ishisaka M,Tsuruma K,Shimazawa M,Yokota K,Shirai Y,Horie K,Saito N,Takeda J,Hara H
MN1020B was used in western blot to investigate the role of diacylglycerol kinase beta in behavioral changes
Mon Oct 18 00:00:00 UTC 2010
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
Journal of neuroinflammation
Stozicka Z,Zilka N,Novak P,Kovacech B,Bugos O,Novak M
MN1020B was used in immunohistochemistry to investigate the effect of genetic background on the pathology of Alzheimer disease rat model
Tue Oct 12 00:00:00 UTC 2010
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
PloS one
Pan-Montojo F,Anichtchik O,Dening Y,Knels L,Pursche S,Jung R,Jackson S,Gille G,Spillantini MG,Reichmann H,Funk RH
MN1020B was used in immunohistochemistry to study the ability of the pesticide and mitochondrial respiratory chain inhibitor rotenone to reproduce Parkinson's disease pathology in the mouse
Tue Jan 19 00:00:00 UTC 2010
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Frontiers in neuroanatomy
Blazquez-Llorca L,Garcia-Marin V,Defelipe J
MN1020B was used in immunohistochemistry to investigate the changes of synapses around tau positive neurons in the hippocampus of Alzheimer disease patients
Thu Jul 14 00:00:00 UTC 2011
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
PLoS genetics
Khurana V,Elson-Schwab I,Fulga TA,Sharp KA,Loewen CA,Mulkearns E,Tyynelä J,Scherzer CR,Feany MB
MN1020B was used in western blot to investigate the role of lysosomal dysfunction in tau cleavage and neurotoxicity in vivo
Thu Jul 15 00:00:00 UTC 2010
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
PloS one
Sharma A,Callahan LM,Sul JY,Kim TK,Barrett L,Kim M,Powers JM,Federoff H,Eberwine J
MN1020B was used in immunohistochemistry to characterize Elk-1 as a link between symptoms of neurodegenerative diseases
Tue Feb 02 00:00:00 UTC 2010
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Journal of neuroinflammation
Minami SS,Sidahmed E,Aid S,Shimoji M,Niikura T,Mocchetti I,Rebeck GW,Prendergast JS,Dealwis C,Wetzel R,Bosetti F,Matsuoka Y,Hoe HS,Turner RS
MN1020B was used in western blot to investigate the benefit vs. adverse effect of passive immunization in an Alzheimer disease model
Tue Sep 28 00:00:00 UTC 2010
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases.
BMC infectious diseases
Wang GR,Shi S,Gao C,Zhang BY,Tian C,Dong CF,Zhou RM,Li XL,Chen C,Han J,Dong XP
MN1020B was used in western blot to evaluate tau expression and phophorylatin profiles in scrapie experimental animals
Thu Apr 01 00:00:00 UTC 2010
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
PloS one
Bittner T,Fuhrmann M,Burgold S,Ochs SM,Hoffmann N,Mitteregger G,Kretzschmar H,LaFerla FM,Herms J
MN1020B was used in immunohistochemistry to investigate the dendritic spine loss during the progression of Alzheimer disease in a mouse model
Tue Nov 16 00:00:00 UTC 2010
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Acta neuropathologica
Nogalska A,Terracciano C,D'Agostino C,King Engel W,Askanas V
MN1020B was used in immunocytochemistry to investigate the distribution of p62 in sporadic inclusion-body myositis muscle fibers and its application as a biomarker
Tue Sep 01 00:00:00 UTC 2009
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.
Brain : a journal of neurology
Lace G,Savva GM,Forster G,de Silva R,Brayne C,Matthews FE,Barclay JJ,Dakin L,Ince PG,Wharton SB
MN1020B was used in immunohistochemistry to investigate the role of hippocampal tau stages in the diagnosis of cognitive impairment
Fri May 01 00:00:00 UTC 2009
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Ohmi K,Kudo LC,Ryazantsev S,Zhao HZ,Karsten SL,Neufeld EF
MN1020B was used in immunohistochemistry to investigate the dysregulation of gene expression and tau phosphorylation in MPS III B mice
Tue May 19 00:00:00 UTC 2009
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Movement disorders : official journal of the Movement Disorder Society
Kovacs GG,Murrell JR,Horvath S,Haraszti L,Majtenyi K,Molnar MJ,Budka H,Ghetti B,Spina S
MN1020B was used in immunohistochemistry to report on a case of TARDBP variation associated with non-ALS neurodegeneration
Tue Sep 15 00:00:00 UTC 2009
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
Movement disorders : official journal of the Movement Disorder Society
Shehadeh L,Mitsi G,Adi N,Bishopric N,Papapetropoulos S
MN1020B was used in immunohistochemistry to investigate the changes of SEPT4 production in Parkinson disease patients
Fri Jan 30 00:00:00 UTC 2009
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Ricobaraza A,Cuadrado-Tejedor M,Pérez-Mediavilla A,Frechilla D,Del Río J,García-Osta A
MN1020B was used in western blot to investigate the effect of phenylbutyrate on neurocognitive function and taupathy in Alzheimer disease murine model
Mon Jun 01 00:00:00 UTC 2009
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Grunberg SC,Bol JG,van Dam AM,Hoozemans JJ,Rozemuller AJ,Drukarch B
MN1020B was used in immunohistochemistry to study the role of transglutaminases and transglutaminase-catalyzed cross-links in Alzheimer's disease pathology
Thu Oct 01 00:00:00 UTC 2009
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
Brain pathology (Zurich, Switzerland)
Vidal R,Barbeito AG,Miravalle L,Ghetti B
MN1020B was used in immunohistochemistry to investigate the neuropathological features in a transgenic mouse model of familial Danish dementia
Thu Jan 01 00:00:00 UTC 2009
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
Neuropathology and applied neurobiology
Sikorska B,Liberski PP,Sobów T,Budka H,Ironside JW
MN1020B was used in immunohistochemistry to investigate the florid plaques in variant Creutzfeldt-Jakob diseases
Sun Feb 01 00:00:00 UTC 2009
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Planel E,Bretteville A,Liu L,Virag L,Du AL,Yu WH,Dickson DW,Whittington RA,Duff KE
MN1020B was used in western blot to investigate the neurofibrillary pathology in a mouse model of tauopathy
Sat Aug 01 00:00:00 UTC 2009
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Journal of neurochemistry
Kasher PR,De Vos KJ,Wharton SB,Manser C,Bennett EJ,Bingley M,Wood JD,Milner R,McDermott CJ,Miller CC,Shaw PJ,Grierson AJ
MN1020B was used in immunocytochemistry to investigate the effect of spastin mutation on the defective axonal transport in the pathogenesis of hereditary spastic paraplegia
Wed Jul 01 00:00:00 UTC 2009
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Neurobiology of aging
Ojala J,Alafuzoff I,Herukka SK,van Groen T,Tanila H,Pirttilä T
MN1020B was used in immunohistochemistry to examine the expression of interleukin 18 in the brains of Alzheimer disease patients
Sun Feb 01 00:00:00 UTC 2009
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Human molecular genetics
Chatterjee S,Sang TK,Lawless GM,Jackson GR
MN1020B was used in western blot to study the roles of GSK3 beta, MARK and Cdk5 in the relationship between tau toxicity and phosphorylation
Thu Jan 01 00:00:00 UTC 2009
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
Human molecular genetics
Tang J,LeGros RP,Louneva N,Yeh L,Cohen JW,Hahn CG,Blake DJ,Arnold SE,Talbot K
MN1020B was used in immunohistochemistry to study isoform-specific Dysbindin-1 decreases in the dorsolateral prefrontal cortex in schizophrenia
Thu Oct 15 00:00:00 UTC 2009
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Journal of Alzheimer's disease : JAD
Campos-Peña V,Tapia-Ramírez J,Sánchez-Torres C,Meraz-Rios MA
MN1020B was used in immunocytochemistry to study the generation of pathological-like tau assemblies at the plasma membrane
Thu Sep 16 00:00:00 UTC 2010
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Journal of Alzheimer's disease : JAD
Capsoni S,Covaceuszach S,Ugolini G,Spirito F,Vignone D,Stefanini B,Amato G,Cattaneo A
MN1020B was used in immunohistochemistry to evaluate intranasal and ocular nerve growth factor administration in mice
Wed Jun 17 00:00:00 UTC 2009
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
FEBS letters
Sasaki K,Shimura H,Itaya M,Tanaka R,Mori H,Mizuno Y,Kosik KS,Tanaka S,Hattori N
MN1020B was used in immunohistochemistry to show the association of excitatory amino acid transporter 2 with phosphorylated tau and its localization in neurofibrillary tangles
Tue Jul 07 00:00:00 UTC 2009
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Brain research
Bitner RS,Nikkel AL,Markosyan S,Otte S,Puttfarcken P,Gopalakrishnan M
MN1020B was used in immunohistochemistry to study the effect of alpha 7 nAChR activation on GSK3 and tau phosphorylation
Fri Apr 10 00:00:00 UTC 2009
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Brain research
Lee HG,Zhu X,Casadesus G,Pallàs M,Camins A,O'Neill MJ,Nakanishi S,Perry G,Smith MA
MN1020B was used in western blot to study the role of mGluR2 in the activation of ERK pathways and neuronal cell survival
Fri Jan 16 00:00:00 UTC 2009
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Biochemical and biophysical research communications
Greco SJ,Sarkar S,Johnston JM,Tezapsidis N
MN1020B was used in western blot to study the regulation of tau phosphorylation and amyloid by leptin in neuronal cells.
Fri Feb 27 00:00:00 UTC 2009
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Neuroscience letters
Greco SJ,Sarkar S,Casadesus G,Zhu X,Smith MA,Ashford JW,Johnston JM,Tezapsidis N
MN1020B was used in western blot to study the role of GSK-3beta in mediating the effectsof leptin on tau phosphorylation in neuronal cells
Fri May 22 00:00:00 UTC 2009
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Journal of neuropathology and experimental neurology
McKee AC,Cantu RC,Nowinski CJ,Hedley-Whyte ET,Gavett BE,Budson AE,Santini VE,Lee HS,Kubilus CA,Stern RA
MN1020B was used in immunohistochemistry to study the progressive tauopathy following repetitive head injury in athletes
Wed Jul 01 00:00:00 UTC 2009
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
PloS one
Willuweit A,Velden J,Godemann R,Manook A,Jetzek F,Tintrup H,Kauselmann G,Zevnik B,Henriksen G,Drzezga A,Pohlner J,Schoor M,Kemp JA,von der Kammer H
MN1020B was used in immunohistochemistry to evaluate the amyloid pathology in a new Alzheimer disease mouse model
Fri Nov 20 00:00:00 UTC 2009
Rapidly progressive neurodegenerative dementias.
Archives of neurology
Josephs KA,Ahlskog JE,Parisi JE,Boeve BF,Crum BA,Giannini C,Petersen RC
MN1020B was used in immunohistochemistry to study the neuropathology of patients with a neurodegenerative disease and a rapidly progressive course to death
Sun Feb 01 00:00:00 UTC 2009
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Aging
Bonda DJ,Evans TA,Santocanale C,Llosá JC,Viña J,Bajic V,Castellani RJ,Siedlak SL,Perry G,Smith MA,Lee HG
MN1020B was used in immunohistochemistry to study aberrant cell cycle progression and abnormal subcellular localization of phosphorylated Mcm2 in Alzheimer's disease and the significance for neronal degeneration
Wed Apr 01 00:00:00 UTC 2009
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
The Journal of biological chemistry
Ittner LM,Ke YD,Götz J
MN1020B was used in western blot to study the interaction between phosphorylated Tau and c-Jun N-terminal kinase-interacting protein 1 in Alzheimer disease
Fri Jul 31 00:00:00 UTC 2009
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
Journal of neural engineering
McConnell GC,Rees HD,Levey AI,Gutekunst CA,Gross RE,Bellamkonda RV
MN1020B was used in immunohistochemistry to study the inflammatory and neurodegenerative effects caused by implanted neural electrodes
Thu Oct 01 00:00:00 UTC 2009
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
PloS one
Rahman A,Ting K,Cullen KM,Braidy N,Brew BJ,Guillemin GJ
MN1020B was used in immunohistochemistry to study the effect of quinolinic acid on tau phosphorylation in neurons
Wed Jul 22 00:00:00 UTC 2009
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
The Journal of clinical investigation
Lim J,Balastik M,Lee TH,Nakamura K,Liou YC,Sun A,Finn G,Pastorino L,Lee VM,Lu KP
MN1020B was used in western blot to investigate the role of Pin1 in the regulation of tau in vivo
Thu May 01 00:00:00 UTC 2008
MAPT S305I mutation: implications for argyrophilic grain disease.
Acta neuropathologica
Kovacs GG,Pittman A,Revesz T,Luk C,Lees A,Kiss E,Tariska P,Laszlo L,Molnár K,Molnar MJ,Tolnay M,de Silva R
MN1020B was used in immunohistochemistry to study the role of MAPT mutation in argyrophilic grain disease.
Tue Jul 01 00:00:00 UTC 2008
Beta-amyloid burden is not associated with rates of brain atrophy.
Annals of neurology
Josephs KA,Whitwell JL,Ahmed Z,Shiung MM,Weigand SD,Knopman DS,Boeve BF,Parisi JE,Petersen RC,Dickson DW,Jack CR
MN1020B was used in immunohistochemistry to investigate the relation between beta-amyloid burden and brain atrophy
Fri Feb 01 00:00:00 UTC 2008
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Yoo MJ,Savonenko A,Stirling W,Price DL,Borchelt DR,Mamounas L,Lyons WE,Blue ME,Lee MK
MN1020B was used in immunocytochemistry to investigate the pathology of MAergic neurons in an Alzheimer disease mouse model
Wed Dec 17 00:00:00 UTC 2008
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Planel E,Krishnamurthy P,Miyasaka T,Liu L,Herman M,Kumar A,Bretteville A,Figueroa HY,Yu WH,Whittington RA,Davies P,Takashima A,Nixon RA,Duff KE
MN1020B was used in western blot to investigate the effect of anesthesia-induced hyperphosphorylation on the detachment of 3-repeat Tau and Tau stability
Wed Nov 26 00:00:00 UTC 2008
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wilcock DM,Lewis MR,Van Nostrand WE,Davis J,Previti ML,Gharkholonarehe N,Vitek MP,Colton CA
MN1020B was used in immunohistochemistry to study the amyloid pathology of Alzheimer disease
Wed Feb 13 00:00:00 UTC 2008
Argyrophilic grains: a distinct disease or an additive pathology?
Neurobiology of aging
Josephs KA,Whitwell JL,Parisi JE,Knopman DS,Boeve BF,Geda YE,Jack CR,Petersen RC,Dickson DW
MN1020B was used in immunohistochemistry to investigate the association between argyrophilic grains and atrophy
Tue Apr 01 00:00:00 UTC 2008
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
Molecular and cellular neurosciences
Hinners I,Hill A,Otto U,Michalsky A,Mack TG,Striggow F
MN1020B was used in immunohistochemistry to study the function of tau kinase inhibitors in protecting hippocampal synapses from accumulation of insoluble tau
Sat Mar 01 00:00:00 UTC 2008
Age and apoE associations with complex pathologic features in Alzheimer's disease.
Journal of the neurological sciences
Jicha GA,Parisi JE,Dickson DW,Cha RH,Johnson KA,Smith GE,Boeve BF,Petersen RC,Knopman DS
MN1020B was used in immunohistochemistry to study the role of age and apoE in Alzheimer disease pathology
Wed Oct 15 00:00:00 UTC 2008
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics
Matsuoka Y,Jouroukhin Y,Gray AJ,Ma L,Hirata-Fukae C,Li HF,Feng L,Lecanu L,Walker BR,Planel E,Arancio O,Gozes I,Aisen PS
MN1020B was used in western blot to investigate the effect of a neuronal microtubule-interacting agent NAPVSIPQ on tau pathology and cognitive function in an Alzheimer disease mouse model
Tue Apr 01 00:00:00 UTC 2008
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.
Hippocampus
Schrag M,Sharma S,Brown-Borg H,Ghribi O
MN1020B was used in immunohistochemistry to examine the resistance of Ames dwarf mice towards the beta-amyloid-induced neurotoxicities
Thu Mar 27 00:00:00 UTC 2008
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Brain research
Laporte V,Ait-Ghezala G,Volmar CH,Ganey C,Ganey N,Wood M,Mullan M
MN1020B was used in immunohistochemistry to study the role of CD40 ligation in plaque-associated tau phosphorylation in beta-amyloid overproducing mice
Mon Sep 22 00:00:00 UTC 2008
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Age (Dordrecht, Netherlands)
Myung NH,Zhu X,Kruman II,Castellani RJ,Petersen RB,Siedlak SL,Perry G,Smith MA,Lee HG
MN1020B was used in immunocytochemistry to investigate the changes of gamma H2AX production in astrocytes of Alzheimer disease patients
Mon Dec 01 00:00:00 UTC 2008
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Cell cycle (Georgetown, Tex.)
Rossi G,Dalprà L,Crosti F,Lissoni S,Sciacca FL,Catania M,Di Fede G,Mangieri M,Giaccone G,Croci D,Tagliavini F
MN1020B was used in immunocytochemistry to study a potential role of tau in chromosome stability via its interaction with chromatin and microtubules
Sun Jun 15 00:00:00 UTC 2008
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
International journal of clinical and experimental pathology
Thakur A,Siedlak SL,James SL,Bonda DJ,Rao A,Webber KM,Camins A,Pallàs M,Casadesus G,Lee HG,Bowser R,Raina AK,Perry G,Smith MA,Zhu X
MN1020B was used in immunocytochemistry to investigate the changes of pRb phosphorylation in neurons of Alzheimer disease patients
Tue Jan 01 00:00:00 UTC 2008
Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.
BMC research notes
Patil S,Balu D,Melrose J,Chan C
MN1020B was used in western blot to investigate the relationship between brain region-specific free fatty acid metabolism and region-specific brain damage observed in Alzheimer disease
Wed Jun 04 00:00:00 UTC 2008
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
The Journal of clinical investigation
Dias-Santagata D,Fulga TA,Duttaroy A,Feany MB
MN1020B was used in western blot to study the role of oxidative stress in tau-induced neurodegeneration in Drosophila
Mon Jan 01 00:00:00 UTC 2007
Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia.
Acta neuropathologica
Munoz DG,Woulfe J,Kertesz A
MN1020B was used in immunohistochemistry to study argyrophilic thorny astrocyte clusters in aphasia
Mon Oct 01 00:00:00 UTC 2007
Rates of cerebral atrophy differ in different degenerative pathologies.
Brain : a journal of neurology
Whitwell JL,Jack CR,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Ferman TJ,Dickson DW,Josephs KA
MN1020B was used in immunohistochemistry to study the neuropathology of patients with different degenerative pathologies
Sun Apr 01 00:00:00 UTC 2007
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology
Leverenz JB,Yu CE,Montine TJ,Steinbart E,Bekris LM,Zabetian C,Kwong LK,Lee VM,Schellenberg GD,Bird TD
MN1020B was used in immunohistochemistry to characterize a new progranulin mutation and its role in tau, TDP43 and alpha-synuclein pathology
Tue May 01 00:00:00 UTC 2007
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Proceedings of the National Academy of Sciences of the United States of America
Luo W,Dou F,Rodina A,Chip S,Kim J,Zhao Q,Moulick K,Aguirre J,Wu N,Greengard P,Chiosis G
MN1020B was used in western blot to study the contribution of heat-shock protein 90 towards tauopathies
Tue May 29 00:00:00 UTC 2007
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Green KN,Martinez-Coria H,Khashwji H,Hall EB,Yurko-Mauro KA,Ellis L,LaFerla FM
MN1020B was used in western blot to study the effect of docosahexaenoic acid and docosapentaenoic acid on amyloid beta and tau pathology
Wed Apr 18 00:00:00 UTC 2007
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Planel E,Richter KE,Nolan CE,Finley JE,Liu L,Wen Y,Krishnamurthy P,Herman M,Wang L,Schachter JB,Nelson RB,Lau LF,Duff KE
MN1020B was used in immunohistochemistry to examine the effect of anesthesia on tau hyperphosphorylation
Wed Mar 21 00:00:00 UTC 2007
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rissman RA,Lee KF,Vale W,Sawchenko PE
MN1020B was used in western blot to investigate the influence of CRFR on tau modification under stress conditions
Wed Jun 13 00:00:00 UTC 2007
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.
Neuropathology and applied neurobiology
Sikorska B,Papierz W,Preusser M,Liberski PP,Budka H
MN1020B was used in immunohistochemistry to characterize a unique case of synucleinopathy with multiple system atrophy and dementia
Thu Feb 01 00:00:00 UTC 2007
Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia.
The international journal of neuropsychopharmacology
Piggott MA,Ballard CG,Dickinson HO,McKeith IG,Perry RH,Perry EK
MN1020B was used in immunohistochemistry to investigate thalamic D2 density in Parkinson disease
Sun Apr 01 00:00:00 UTC 2007
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
Journal of neurochemistry
Leschik J,Welzel A,Weissmann C,Eckert A,Brandt R
MN1020B was used in western blot to investigate the regulatory effect of presenilin 1 and amyloid-beta on tau-dependent neurodegeneration
Fri Jun 01 00:00:00 UTC 2007
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.
Neurobiology of aging
Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM
MN1020B was used in immunohistochemistry to investigate the pathological changes in locus coeruleus of Alzheimer disease patients
Thu Mar 01 00:00:00 UTC 2007
Inflammatory changes parallel the early stages of Alzheimer disease.
Neurobiology of aging
Parachikova A,Agadjanyan MG,Cribbs DH,Blurton-Jones M,Perreau V,Rogers J,Beach TG,Cotman CW
MN1020B was used in immunohistochemistry to study the immune dysfunction in early stages of Alzheimer disease
Sat Dec 01 00:00:00 UTC 2007
Insular pathology in Parkinson's disease patients with orthostatic hypotension.
Parkinsonism & related disorders
Papapetropoulos S,Mash DC
MN1020B was used in immunohistochemistry to study the association between the severity of insular cortex pathology in Parkinson's disease and the occurrence orthostatic hypotension
Sun Jul 01 00:00:00 UTC 2007
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.
Journal of neural transmission (Vienna, Austria : 1996)
Papapetropoulos S,Mash DC
MN1020B was used in immunohistochemistry to investigate the prevalence of motor fluctuations and dyskinesias in end stage patients with Parkinson disease
Thu Mar 01 00:00:00 UTC 2007
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Neuroscience letters
Magaki S,Raghavan R,Mueller C,Oberg KC,Vinters HV,Kirsch WM
MN1020B was used in immunohistochemistry to study the role of iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias
Fri May 11 00:00:00 UTC 2007
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Journal of neuropathology and experimental neurology
Moreira PI,Siedlak SL,Wang X,Santos MS,Oliveira CR,Tabaton M,Nunomura A,Szweda LI,Aliev G,Smith MA,Zhu X,Perry G
MN1020B was used in immunohistochemistry to investigate the autophagocytosis of mitochondria in Alzheimer disease
Fri Jun 01 00:00:00 UTC 2007
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Journal of neuropathology and experimental neurology
Josephs KA,Ahmed Z,Katsuse O,Parisi JF,Boeve BF,Knopman DS,Petersen RC,Davies P,Duara R,Graff-Radford NR,Uitti RJ,Rademakers R,Adamson J,Baker M,Hutton ML,Dickson DW
MN1020B was used in immunohistochemistry to conduct neuropathologic analysis on frontotemporal lobar degeneration
Thu Feb 01 00:00:00 UTC 2007
Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.
Forensic science international
Gelpi E,Preusser M,Bauer G,Budka H
MN1020B was used in immunohistochemistry to study neuropathological features of a brain fixed 2 months after death
Thu May 24 00:00:00 UTC 2007
Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.
Synapse (New York, N.Y.)
Piggott MA,Ballard CG,Rowan E,Holmes C,McKeith IG,Jaros E,Perry RH,Perry EK
MN1020B was used in immunohistochemistry to investigate the changes of D2 receptors in dementia patients
Thu Nov 01 00:00:00 UTC 2007
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Neuropathology : official journal of the Japanese Society of Neuropathology
Preusser M,Kitzwoegerer M,Budka H,Brugger S
MN1020B was used in immunohistochemistry to investigate the changes of brain structure in a patient with longstanding hypoparathyroidism
Mon Oct 01 00:00:00 UTC 2007
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
International journal of medical sciences
Evans TA,Raina AK,Delacourte A,Aprelikova O,Lee HG,Zhu X,Perry G,Smith MA
MN1020B was used in immunohistochemistry to study the role of BRCA1 in Alzheimer disease
Sat May 12 00:00:00 UTC 2007
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Brain : a journal of neurology
Boeve BF,Baker M,Dickson DW,Parisi JE,Giannini C,Josephs KA,Hutton M,Pickering-Brown SM,Rademakers R,Tang-Wai D,Jack CR,Kantarci K,Shiung MM,Golde T,Smith GE,Geda YE,Knopman DS,Petersen RC
MN1020B was used in immunohistochemistry to investigate the relationship between frontotemporal dementia and parkinsonism and progranulin mutation
Wed Nov 01 00:00:00 UTC 2006
Neuropathology in the S305S tau gene mutation.
Brain : a journal of neurology
Halliday GM,Song YJ,Creasey H,Morris JG,Brooks WS,Kril JJ
MN1020B was used in immunohistochemistry to study the neuropathology of S305S mutation in tau gene
Wed Mar 01 00:00:00 UTC 2006
Memory complaints are related to Alzheimer disease pathology in older persons.
Neurology
Barnes LL,Schneider JA,Boyle PA,Bienias JL,Bennett DA
MN1020B was used in immunohistochemistry to investigate the relationship between memory complaints and Alzheimer disease pathology
Tue Nov 14 00:00:00 UTC 2006
A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
Neurobiology of disease
Blain JF,Sullivan PM,Poirier J
MN1020B was used in western blot to investigate the effect of apoE4 on astroglial repair process and synaptic remodeling
Wed Mar 01 00:00:00 UTC 2006
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wahle T,Thal DR,Sastre M,Rentmeister A,Bogdanovic N,Famulok M,Heneka MT,Walter J
MN1020B was used in immunohistochemistry to study the expression of GGA1 and its effect on amyloid beta peptide
Wed Dec 06 00:00:00 UTC 2006
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.
Experimental neurology
Ghribi O,Larsen B,Schrag M,Herman MM
MN1020B was used in western blot to study the effect of high cholesterol content on BACE, beta-amyloid and phosphorylated tau levels in hippocampus
Tue Aug 01 00:00:00 UTC 2006
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Journal of neuroscience research
Lee HG,Ueda M,Zhu X,Perry G,Smith MA
MN1020B was used in immunocytochemistry to investigate the alteration of transforming growth factor-beta pathway in Alzheimer disease
Fri Dec 01 00:00:00 UTC 2006
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
Journal of neuroscience research
Oka T,Tamada Y,Nakajima E,Shearer TR,Azuma M
MN1020B was used in western blot to demonstrate the assocation of calpain-dependent proteolysis with inner retinal neuronal cell death and retinal dysfunction
Mon May 15 00:00:00 UTC 2006
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations.
Parkinsonism & related disorders
Papapetropoulos S,McCorquodale DS,Gonzalez J,Jean-Gilles L,Mash DC
MN1020B was used in immunohistochemistry to study the Lewy body in Parkinson disease
Mon May 01 00:00:00 UTC 2006
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
Journal of neuropathology and experimental neurology
Jicha GA,Petersen RC,Knopman DS,Boeve BF,Smith GE,Geda YE,Johnson KA,Cha R,Delucia MW,Braak H,Dickson DW,Parisi JE
MN1020B was used in immunohistochemistry to study the argyrophilic grain disease pathology in demented subjects with amnestic mild cognitive impairment
Thu Jun 01 00:00:00 UTC 2006
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
Journal of feline medicine and surgery
Gunn-Moore DA,McVee J,Bradshaw JM,Pearson GR,Head E,Gunn-Moore FJ
MN1020B was used in immunohistochemistry to study the age-dependent pathological changes in cat brains
Tue Aug 01 00:00:00 UTC 2006
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Methods in enzymology
Ikonomovic MD,Abrahamson EE,Isanski BA,Debnath ML,Mathis CA,Dekosky ST,Klunk WE
MN1020B was used in immunohistochemistry to describe methods for the fluorescent labeling of abnormal protein aggregates in Alzheimer's disease
Tue Nov 14 00:00:00 UTC 2006
Cognitive impairment and celiac disease.
Archives of neurology
Hu WT,Murray JA,Greenaway MC,Parisi JE,Josephs KA
MN1020B was used in immunohistochemistry to characterize the histological features of cognitive impaired patients associated with celiac disease
Sun Oct 01 00:00:00 UTC 2006
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Archives of neurology
Jicha GA,Parisi JE,Dickson DW,Johnson K,Cha R,Ivnik RJ,Tangalos EG,Boeve BF,Knopman DS,Braak H,Petersen RC
MN1020B was used in immunohistochemistry to investigate the neuropathologic outcome of mild cognitive impairment following progression to clinical dementia
Mon May 01 00:00:00 UTC 2006
Tau interacts with Golgi membranes and mediates their association with microtubules.
Cell motility and the cytoskeleton
Farah CA,Perreault S,Liazoghli D,Desjardins M,Anton A,Lauzon M,Paiement J,Leclerc N
MN1020B was used in western blot to study the interaction between Tau and Golgi membranes and its function
Wed Nov 01 00:00:00 UTC 2006
Neuropathologic features of amnestic mild cognitive impairment.
Archives of neurology
Petersen RC,Parisi JE,Dickson DW,Johnson KA,Knopman DS,Boeve BF,Jicha GA,Ivnik RJ,Smith GE,Tangalos EG,Braak H,Kokmen E
MN1020B was used in immunohistochemistry to compare the amyloid and neurofibrillary pathologic features in healthy, amnestic mild cognitive impairment, and Alzheimer disease cases
Mon May 01 00:00:00 UTC 2006
Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates.
Acta neuropathologica
Fukuda T,Shimizu J,Furuhata H,Abe T,Shimizu K,Oishi T,Ogihara M,Kubota J,Sasaki A,Sasaki K,Azuma T,Umemura S
MN1020B was used in immunohistochemistry to study HSP overexpression in nonhuman aged primate pallido-nigral axonal spheroids
Mon Aug 01 00:00:00 UTC 2005
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Acta neuropathologica
Newman J,Rissman RA,Sarsoza F,Kim RC,Dick M,Bennett DA,Cotman CW,Rohn TT,Head E
MN1020B was used in immunohistochemistry to study the accumulation of Tau fragments in neurodegenerative diseases
Mon Aug 01 00:00:00 UTC 2005
Antemortem diagnosis of frontotemporal lobar degeneration.
Annals of neurology
Knopman DS,Boeve BF,Parisi JE,Dickson DW,Smith GE,Ivnik RJ,Josephs KA,Petersen RC
MN1020B was used in immunohistochemistry to diagnose and classify frontotemporal lobar degenerations based on tau and ubiquitin immunostaining
Fri Apr 01 00:00:00 UTC 2005
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Annals of neurology
Obici L,Demarchi A,de Rosa G,Bellotti V,Marciano S,Donadei S,Arbustini E,Palladini G,Diegoli M,Genovese E,Ferrari G,Coverlizza S,Merlini G
MN1020B was used in immunohistochemistry to investigate the association between a APP mutation and cerebral amyloid angiopathy.
Sat Oct 01 00:00:00 UTC 2005
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
Movement disorders : official journal of the Movement Disorder Society
Klos KJ,Josephs KA,Parisi JE,Dickson DW
MN1020B was used in immunohistochemistry to study the clinicopathological features of co-occurring idiopathic Parkinson disease and motor neuron disease
Tue Nov 01 00:00:00 UTC 2005
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Experimental neurology
Frasier M,Walzer M,McCarthy L,Magnuson D,Lee JM,Haas C,Kahle P,Wolozin B
MN1020B was used in immunohistochemistry to study the effect of A30P alpha synuclein on tau phosphorylation
Fri Apr 01 00:00:00 UTC 2005
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
Toxicology
Sakaue M,Okazaki M,Hara S
MN1020B was used in western blot to investigate the mechanism of apoptosis stimulated by methylmercury in vivo
Thu Sep 15 00:00:00 UTC 2005
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Journal of neuropathology and experimental neurology
Hung KS,Hwang SL,Liang CL,Chen YJ,Lee TH,Liu JK,Howng SL,Wang CH
MN1020B was used in immunohistochemistry to investigate the influence of calpain inhibition on spinal cord hemisection treatment
Sat Jan 01 00:00:00 UTC 2005
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Brain research. Developmental brain research
Yang W,Ang LC,Strong MJ
MN1020B was used in immunohistochemistry to characterize the age-dependent tau protein aggregation in frontal and entorhinal cortices
Thu May 12 00:00:00 UTC 2005
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Acta neuropathologica
Lee HG,Ogawa O,Zhu X,O'Neill MJ,Petersen RB,Castellani RJ,Ghanbari H,Perry G,Smith MA
MN1020B was used in immunocytochemistry to study the involvement of metabotropic glutamate receptor 2 in the pathogenesis of Alzheimer disease
Thu Apr 01 00:00:00 UTC 2004
Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease.
Brain : a journal of neurology
Heckmann JM,Low WC,de Villiers C,Rutherfoord S,Vorster A,Rao H,Morris CM,Ramesar RS,Kalaria RN
MN1020B was used in immunohistochemistry to investigate the phenotypes of Southern African patients with presenilin 1 disruption
Thu Jan 01 00:00:00 UTC 2004
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Annals of neurology
Mesulam M,Shaw P,Mash D,Weintraub S
MN1020B was used in immunohistochemistry to study cholinergic nucleus basalis tauopathy at the early stage of neurodegeneration
Tue Jun 01 00:00:00 UTC 2004
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Journal of neuropathology and experimental neurology
Vidal R,Ghetti B,Takao M,Brefel-Courbon C,Uro-Coste E,Glazier BS,Siani V,Benson MD,Calvas P,Miravalle L,Rascol O,Delisle MB
MN1020B was used in immunohistochemistry to investigate ferritin accumulation in neurodegenerative diseases
Thu Apr 01 00:00:00 UTC 2004
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
The Journal of biological chemistry
Shimura H,Miura-Shimura Y,Kosik KS
MN1020B was used in western blot to investigate the influence of heat shock protein 27 interaction with tau on tau phosphorylation and cell survival
Fri Apr 23 00:00:00 UTC 2004
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
The Journal of biological chemistry
Li G,Yin H,Kuret J
MN1020B was used in western blot to study the tau phosphorylation by Cki delta and its effect on microtubule binding
Fri Apr 16 00:00:00 UTC 2004
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Journal of neurology, neurosurgery, and psychiatry
Tang-Wai DF,Josephs KA,Boeve BF,Petersen RC,Parisi JE,Dickson DW
MN1020B was used in immunohistochemistry to study a clinical case with both Lewy body and Alzheimer diseases
Sat Mar 01 00:00:00 UTC 2003
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Journal of neurochemistry
Zhu X,Sun Z,Lee HG,Siedlak SL,Perry G,Smith MA
MN1020B was used in immunocytochemistry to characterize the MEK1 protein in Alzheimer disease
Tue Jul 01 00:00:00 UTC 2003
Neuropathology of cognitively normal elderly.
Journal of neuropathology and experimental neurology
Knopman DS,Parisi JE,Salviati A,Floriach-Robert M,Boeve BF,Ivnik RJ,Smith GE,Dickson DW,Johnson KA,Petersen LE,McDonald WC,Braak H,Petersen RC
MN1020B was used in immunohistochemistry to investigate the neuropathology of cognitively normal elderly
Sat Nov 01 00:00:00 UTC 2003
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.
The Journal of biological chemistry
Agarwal-Mawal A,Qureshi HY,Cafferty PW,Yuan Z,Han D,Lin R,Paudel HK
MN1020B was used in western blot to investigate the role of 14-3-3 in tau function in brain
Fri Apr 11 00:00:00 UTC 2003
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Biochemistry
Yoshida H,Goedert M
MN1020B was used in western blot to investigate the function of chicken brain tau
Tue Dec 24 00:00:00 UTC 2002
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ko J,Humbert S,Bronson RT,Takahashi S,Kulkarni AB,Li E,Tsai LH
MN1020B was used in western blot to investigate the role of p35 and p39 in the regulation of cyclin-dependent kinase 5 activity during neurodevelopment
Sat Sep 01 00:00:00 UTC 2001
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
The American journal of pathology
King ME,Ghoshal N,Wall JS,Binder LI,Ksiezak-Reding H
MN1020B was used in western blot to investigate the differences between the structure of tau filaments from variant sources
Sun Apr 01 00:00:00 UTC 2001
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Mechanisms of ageing and development
Zhu X,Castellani RJ,Takeda A,Nunomura A,Atwood CS,Perry G,Smith MA
MN1020B was used in immunocytochemistry to investigate the regulation of MAPK pathways during the progression of Alzheimer disease
Sat Dec 01 00:00:00 UTC 2001
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Acta neuropathologica
Braak E,Braak H,Mandelkow EM
MN1020B was used in immunocytochemistry to investigate the correlation between the changes in the cytoskeleton and the formation of neurofibrillary tangles and neuropil threads
Mon Oct 17 00:00:00 UTC 1994
