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It is not recommended to aliquot this antibody.
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
基因别名: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA
UniProt ID: (Human) Q9UIU7, (Mouse) Q3UFB7, (Rat) P35739
Entrez Gene ID: (Human) 4914, (Mouse) 18211, (Rat) 59109
分子生物学功能: transmembrane signal receptor