应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
免疫沉淀 (IP) |
1:100 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic phosphopeptide corresponding to residues surrounding pTyr490 of human TrkA |
偶联物 |
Unconjugated |
形式 |
Liquid |
纯化类型 |
Antigen affinity chromatography |
保存液 |
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
内含物 |
no preservative |
保存条件 |
-20°C |
RRID |
AB_10983106 |
It is not recommended to aliquot this antibody.
TrkA (tropomyosin receptor kinase A) encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
基因别名: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA
UniProt ID: (Human) P04629, (Mouse) Q3UFB7, (Rat) P35739
Entrez Gene ID: (Human) 4914, (Mouse) 18211, (Rat) 59109
分子生物学功能:
transmembrane signal receptor