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Invitrogen
RNA pol II CTD Monoclonal Antibody
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RNA pol II CTD Antibody (49-1033) in ChIP-seq
ChIP was performed on sheared chromatin from 1 million HeLaS3 cells using 2 µL of the anti-Pol II antibody (Product # 49-1033). The IP’d DNA was subsequently analysed on an Illumina HiSeq. Library preparation, cluster generation and sequencing were performed according to the manufacturer’s instructions. The 51 bp tags were aligned to the human genome using the BWA algorithm. The figure shows the enrichment ... View More
产品信息
49-1033
应用
建议稀释比
已发表文章
产品规格
已发表种属
C. elegans,
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
抗原
Raised against the largest subunit of RNA polymerase II of wheat germ and interacts with the highly conserved C-terminal domain of this protein containing the repeat YSPTSPS.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
RNA polymerase II is the enzyme responsible for the synthesis of mRNA and many non-coding RNAs. POLR2A encodes RNA polymerase II subunit B1 (RPB1), the largest subunit of RNA polymerase II. The C-terminal domain (CTD) of RPB1 contains tandem heptapeptide repeats with the consensus sequence YSPTSPS. Phosphorylation and other modifications within this sequence influence the recruitment of factors that regulate the transcription cycle. Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the CTD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
