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Proteintech
RNF8 Polyclonal Antibody
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产品信息
14112-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RNF8 Fusion Protein Ag5292 (130-485 aa encoded by BC007517)
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ETIYPCLSP KNDQMIEKNK ELRTKRKFSL DELAGPGAEG PSNLKSKINK VSCESGQPVK SQGKGEVAST PSDNLDPKLT ALEPSKTTGA PIYPGFPKVT EVHHEQKASN SSASQRSLQM FKVTMSRILR LKIQMQEKHE AVMNVKKQTQ KGNSKKVVQM EQELQDLQSQ LCAEQAQQQA RVEQLEKTFQ EEEQHLQGLE IAQGEKDLKQ QLAQALQEHW ALMEELNRSK KDFEAIIQAK NKELEQTKEE KEKMQAQKEE VLSHMNDVLE NELQCIICSE YFIEAVTLNC AHSFCSYCIN EWMKRKIECP ICRKDIKSKT YSLVLDNCIN KMVNNLSSEV KERRIVLIRE RKAKRLF (130-485 aa encoded by BC007517 )
靶标信息
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ActA binding protein 2; ActA-interacting protein 37; AIP37; C3HC4-type zinc finger protein; E3 ubiquitin-protein ligase RNF8; FLJ12013; hRNF8; LaXp180; OTTHUMP00000039684; ring finger protein (C3HC4 type) 8; RING finger protein 8; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8; UBC13/UEV-interacting ring finger protein
基因别名: 3830404E21Rik; AIP37; hRNF8; KIAA0646; RNF8
UniProt ID: (Human) O76064, (Rat) Q4KLN8, (Mouse) Q8VC56
Entrez Gene ID: (Human) 9025, (Rat) 361815, (Mouse) 58230
chromatin binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
ubiquitin protein ligase binding
histone binding
protein homodimerization activity
molecular_function
acid-amino acid ligase activity
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
double-strand break repair
double-strand break repair via nonhomologous end joining
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
mitotic nuclear division
spermatid development
response to ionizing radiation
histone H2A ubiquitination
histone H2B ubiquitination
negative regulation of transcription elongation from RNA polymerase II promoter
interstrand cross-link repair
histone exchange
isotype switching
positive regulation of DNA repair
cell division
protein autoubiquitination
protein K63-linked ubiquitination
histone H2A K63-linked ubiquitination
protein K48-linked ubiquitination
biological_process
DNA repair
cell cycle
protein ubiquitination
chromatin modification
