Invitrogen

Rat IFN-beta Recombinant Protein

产品信息

134001

应用	建议稀释比	已发表文章
免疫印迹 (WB)	Assay-dependent	-
酶联免疫吸附实验 (ELISA)	Assay-dependent	-
免疫沉淀 (IP)	Assay-dependent	-

产品规格
种属	Mouse, Rat
表达系统	CHO cells
分子量	19.68 kDa
分类	Recombinant
类型	Protein
纯度	>95%
内毒素浓度	<1 EU/µg
活性	EC50 ~ 1 U/mL; determined by use of the cytopathic effect inhibition assay described in [Rubinstein, S. et al. (1981). J. Virol. 37, 755-758]; [Familletti, P.C. et al. (1981). Methods in Enzymology, Vol. 78, 387-394]As there is no international Rat IFN-alpha standard, units are determined with respect to the international reference standard for mouse interferon alpha/beta (mouse IFN-alpha/beta) provided by the National Institutes of Health.
偶联物	Unconjugated
形式	Lyophilized
纯化类型	purified
保存液	PBS with 0.125M trehalose
内含物	no preservative
保存条件	4° C

产品详细信息

After receipt, this product should be kept at -20°C while lyophilized and at -70°C after reconstitution in sterile distilled water for retention of full activity. After reconstitution, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. After thawing, this product is stable for at least four weeks at 4°C. Further dilute only in buffers containing protein such as 0.1% bovine serum albumin (BSA).

靶标信息

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。