Proteintech

Rb Polyclonal Antibody

27 篇参考文献
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Rb Polyclonal Antibody

产品信息

17218-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
查看22篇已发表文章 22篇已发表文章

其他PubMed (Misc)

-
查看2篇已发表文章 2篇已发表文章

不适用 (N/A)

-
查看3篇已发表文章 3篇已发表文章
产品规格

种属反应

Human

已发表种属

Human, Rat, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Rb Fusion Protein Ag11035 (576-928 aa encoded by BC039060)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.14 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human RB1.

Immunogen sequence: SKDREGPTD HLESACPLNL PLQNNHTAAD MYLSPVRSPK KKGSTTRVNS TANAETQATS AFQTQKPLKS TSLSLFYKKV YRLAYLRLNT LCERLLSEHP ELEHIIWTLF QHTLQNEYEL MRDRHLDQIM MCSMYGICKV KNIDLKFKII VTAYKDLPHA VQETFKRVLI KEEEYDSIIV FYNSVFMQRL KTNILQYAST RPPTLSPIPH IPRSPYKFPS SPLRIPGGNI YISPLKSPYK ISEGLPTPTK MTPRSRILVS IGESFGTSEK FQKINQMVCN SDRVLKRSAE GSNPPKPLKK LRFDIEGSDE ADGSKHLPGE SKFQQKLAEM TSTRTRMQKQ KMNDSMDTSN KEEK (576-928 aa encoded by B C039060)

靶标信息

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; p105-Rb; P105RB; p110-RB1; Phospho-Retinoblastoma; pp110; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma gene; retinoblastoma suspectibility protein; Retinoblastoma-associated protein

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基因别名: OSRC; p105-Rb; pp110; PPP1R130; pRb; RB; RB1

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UniProt ID: (Human) P06400

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Entrez Gene ID: (Human) 5925

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功能
core promoter binding RNA polymerase II activating transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding kinase binding ubiquitin protein ligase binding identical protein binding androgen receptor binding phosphoprotein binding chromatin/chromatin-binding, or -regulatory protein
参与通路
cell cycle checkpoint G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle chromatin remodeling transcription, DNA-templated negative regulation of protein kinase activity cell cycle arrest negative regulation of transcription from RNA polymerase II promoter during mitosis mitotic cell cycle checkpoint Ras protein signal transduction regulation of mitotic cell cycle negative regulation of gene expression viral process covalent chromatin modification androgen receptor signaling pathway sister chromatid biorientation neuron projection development maintenance of mitotic sister chromatid cohesion glial cell apoptotic process skeletal muscle cell differentiation neuron maturation enucleate erythrocyte differentiation negative regulation of sequence-specific DNA binding transcription factor activity regulation of lipid kinase activity myoblast differentiation positive regulation of macrophage differentiation positive regulation of mitotic metaphase/anaphase transition negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development cell morphogenesis involved in neuron differentiation negative regulation of epithelial cell proliferation striated muscle cell differentiation cell division neuron apoptotic process protein localization to chromosome, centromeric region cellular response to xenobiotic stimulus regulation of cohesin loading negative regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of centromere complex assembly hepatocyte apoptotic process negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription regulatory region DNA binding
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