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LRFN5 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while LRFN2 and LRFN5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Leucine-rich repeat and fibronectin type-III domain-containing protein 5
基因别名: AI427653; AI604817; C130061B21; Kiaa4208; Lrfn5; mKIAA4208; Salm5
UniProt ID: (Mouse) Q8BXA0
Entrez Gene ID: (Mouse) 238205