FIGURE: 1 / 5
Immunogen sequence: SLDAVMPHLM HQHKSITTLQ GEDIVFLATD INLPGAVDWV MMQSCFGFHF MLVLEKQEKY DGHQQFFAIV QLIGTRKQAE NFAYRLELNG HRRRLTWEAT PRSIHEGIAT AIMNSDCLVF DTSIAQLFAE NGNLGINVTI SMC
Positive Samples: Mouse kidney; Cellular Location: Cytoplasm, Nucleus
This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase SIAH1A; E3 ubiquitin-protein ligase SIAH1B; FLJ08065; h HUMSIAH; hSIAH1; mSiah-1a; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH1A; RING-type E3 ubiquitin transferase SIAH1B; seven in absentia 1A; Seven in absentia homolog 1; Seven in absentia homolog 1a; Seven in absentia homolog 1b; Siah-1; Siah-1a; Siah-1b
Gene Aliases: AA960570; AA982064; AI853500; HUMSIAH; SIAH; siah-1b; SIAH1; SIAH1A; Siah1b; Sinh1a; Sinh1b