Invitrogen

SOD1 Polyclonal Antibody

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说明书
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SOD1 Polyclonal Antibody

产品信息

PA1-18275

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫细胞化学 (ICC/IF)

1:200
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues A(24) S G E P V V L S G Q I T(36) of mouse superoxide dismutase (SOD1).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1087610

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

靶标信息

SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu/Zn SOD; HGNC:11179; Indophenoloxidase A (IPOA); superoxide dismutase; Superoxide Dismutase 1 (SOD1); Superoxide dismutase [Cu-Zn]

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基因别名: B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1; Ipo1; Sod-1; Sod1; SODC

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UniProt ID: (Mouse) P08228, (Rat) P07632

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Entrez Gene ID: (Mouse) 20655, (Rat) 24786

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功能
superoxide dismutase activity copper ion binding protein binding zinc ion binding antioxidant activity oxidoreductase activity enzyme binding protein phosphatase 2B binding identical protein binding metal ion binding Rac GTPase binding chaperone binding oxidoreductase
参与通路
activation of MAPK activity response to reactive oxygen species response to superoxide ovarian follicle development positive regulation of cytokine production retina homeostasis myeloid cell homeostasis glutathione metabolic process superoxide metabolic process cellular iron ion homeostasis response to oxidative stress spermatogenesis embryo implantation aging cell aging sensory perception of sound locomotory behavior anterograde axonal transport retrograde axonal transport regulation of blood pressure response to heat response to organic substance transmission of nerve impulse removal of superoxide radicals response to nutrient levels peripheral nervous system myelin maintenance positive regulation of superoxide anion generation regulation of multicellular organism growth response to drug response to hydrogen peroxide superoxide anion generation negative regulation of apoptotic process positive regulation of catalytic activity regulation of GTPase activity negative regulation of neuron apoptotic process response to ethanol negative regulation of cholesterol biosynthetic process regulation of protein kinase activity response to copper ion muscle cell cellular homeostasis response to axon injury hydrogen peroxide biosynthetic process regulation of mitochondrial membrane potential oxidation-reduction process heart contraction neurofilament cytoskeleton organization relaxation of vascular smooth muscle auditory receptor cell stereocilium organization reactive oxygen species metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway response to amphetamine double-strand break repair apoptotic DNA fragmentation response to carbon monoxide cellular response to oxidative stress cellular response to potassium ion response to antibiotic cellular response to cadmium ion cellular response to ATP response to antipsychotic drug
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