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Proteintech
SPIRE2 Polyclonal Antibody
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产品信息
17757-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SPIRE2 Fusion Protein Ag12117 (318-666 aa encoded by BC111030)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: IRSRPPLKQ VSERRLRPLP PKQRSLHEKI LEEIKQERRL RPVRGEGWAA RGFGSLPCIL NACSGDAKST SCINLSVTDA GGSAQRPRPR VLLKAPTLAE MEEMNTSEEE ESPCGEVTLK RDRSFSEHDL AQLRSEVASG LQSATHPPGG TEPPRPRAGS AHVWRPGSRD QGTCPASVSD PSHPLLSNRG SSGDRPEASM TPDAKHLWLE FSHPVESLAL TVEEVMDVRR VLVKAEMEKF LQNKELFSSL KKGKICCCCR AKFPLFSWPP SCLFCKRSLQ GPQWQSVEEA FPHIYSHGCV LKDVCSECTS FVADVVRSSR KSVDVLNTTP RRSRQTQSLY IPNTRTLDFK (318-666 aa encoded by BC111030)
靶标信息
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Protein spire homolog 2; Spir-2; spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; spire-type actin nucleation factor 2
基因别名: BC026502; KIAA1832; Spir-2; SPIR2; SPIRE2
UniProt ID: (Human) Q8WWL2, (Mouse) Q8K1S6
Entrez Gene ID: (Human) 84501, (Rat) 307925, (Mouse) 234857
