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产品信息
PA5-50890
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:10-1:50 | - |
免疫组化（冰冻） (IHC (F)) |
- | 查看1篇已发表文章 1篇已发表文章 |
| 产品规格 | |
|---|---|
种属反应 |
Human |
已发表种属 |
Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to a region derived from internal residues of human sulfatase 1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636342 |
产品详细信息
The antibody detects endogenous levels of total SULF1 protein.
靶标信息
Heparan sulfate proteoglycans act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Extracellular sulfatase Sulf-1; FLJ30905; FLJ38022; FLJ41750; hSulf-1; sulfatase FP
基因别名: KIAA1077; SULF-1; SULF1
UniProt ID: (Human) Q86YV8
Entrez Gene ID: (Human) 23213
分子生物学功能:
hydrolase
kidney development
negative regulation of endothelial cell proliferation
chondrocyte development
glomerular filtration
apoptotic process
positive regulation of vascular endothelial growth factor production
esophagus smooth muscle contraction
negative regulation of angiogenesis
positive regulation of Wnt signaling pathway
heparan sulfate proteoglycan metabolic process
negative regulation of cell migration
positive regulation of BMP signaling pathway
glomerular basement membrane development
glial cell-derived neurotrophic factor receptor signaling pathway
regulation of fibroblast growth factor receptor signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
embryonic skeletal system development
cartilage development
bone development
innervation
negative regulation of prostatic bud formation
