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Proteintech
TDG Recombinant Rabbit Monoclonal Antibody (240715E12)
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产品信息
83780-3-RR
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
240715E12
抗原
TDG fusion protein Ag4190
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MEAENAGSY SLQQAQAFYT FPFQQLMAEA PNMAVVNEQQ MPEEVPAPAP AQEPVQEAPK GRKRKPRTTE PKQPVEPKKP VESKKSGKSA KSKEKQEKIT DTFKVKRKVD RFNGVSEAEL LTKTLPDILT FNLDIVIIGI NPGLMAAYKG HHYPGPGNHF WKCLFMSGLS EVQLNHMDDH TLPGKYGIGF TNMVERTTPG SKDLSSKEFR EGGRILVQKL QKYQPRIAVF NGKCIYEIFS KEVFGVKVKN LEFGLQPHKI PDTETLCYGM PSSSARCAQF PRAQDKVHYY IKLKDLRDQL KGIERNMDVQ EVQYTFDLQL AQEDAKKMAV KEEKYDPGYE AAYGGAYGEN PCSSEPCGFS SNGLIESVEL RGESAFSGIP NGQWMTQSFT DQIPSFSNHC GTQEQEEESH A
靶标信息
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G/T mismatch-specific thymine DNA glycosylase; hTDG; Thymine-DNA glycosylase
基因别名: hTDG; TDG
UniProt ID: (Human) Q13569
Entrez Gene ID: (Human) 6996
RNA polymerase II transcription cofactor activity
damaged DNA binding
double-stranded DNA binding
uracil DNA N-glycosylase activity
protein kinase C binding
protein binding
pyrimidine-specific mismatch base pair DNA N-glycosylase activity
DNA N-glycosylase activity
mismatched DNA binding
SUMO binding
protein homodimerization activity
structure-specific DNA binding
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
base-excision repair
base-excision repair, AP site formation
mismatch repair
transcription, DNA-templated
embryo development
covalent chromatin modification
protein sumoylation
negative regulation of protein binding
oxidative DNA demethylation
negative regulation of chromatin binding
regulation of gene expression, epigenetic
depyrimidination
DNA demethylation
