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MA5-15413 targets TNK1 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15413 immunogen is purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
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TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD38 negative kinase 1; MGC46193; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor 1; tyrosine kinase, non-receptor, 1
基因别名: TNK1
UniProt ID: (Human) Q13470
Entrez Gene ID: (Human) 8711