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Invitrogen
TRBP Polyclonal Antibody
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图: 1 / 4
TRBP Antibody (PA5-106384) in ICC/IF
Immunofluorescent analysis of TRBP in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and TRBP polyclonal antibody (Product # PA5-106384) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106384
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TARBP2(Accession Q15633), corresponding to amino acid residues H244-C294.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total TRBP.
靶标信息
TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PRM-1 RNA-binding protein; Protamine-1 RNA-binding protein; RISC-loading complex subunit TARBP2; RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}; TAR (HIV) RNA binding protein 2; TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein
基因别名: Prbp; TARBP2; TRBP
UniProt ID: (Mouse) P97473, (Rat) Q3SWU0
Entrez Gene ID: (Mouse) 21357, (Rat) 363006
regulation of translation
spermatid development
single fertilization
production of siRNA involved in RNA interference
targeting of mRNA for destruction involved in RNA interference
gene silencing by RNA
pre-miRNA processing
siRNA loading onto RISC involved in RNA interference
production of miRNAs involved in gene silencing by miRNA
multicellular organism growth
miRNA loading onto RISC involved in gene silencing by miRNA
positive regulation of viral genome replication
positive regulation of translation
regulation of viral transcription
negative regulation of defense response to virus by host
biological_process
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