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Proteintech
TTC30A Polyclonal Antibody
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产品信息
25352-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TTC30A Fusion Protein Ag18361 (1-342 aa encoded by BC042848)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAGLSGAQI PDGEFTALVY RLIRDARYAE AVQLLGRELQ RSPRSRAGLS LLGYCYYRLQ EFALAAECYE QLGQLHPELE QYRLYQAQAL YKACLYPEAT RVAFLLLDNP AYHSRVLRLQ AAIKYSEGDL PGSRSLVEQL LSGEGGEESG GDNETDGQVN LGCLLYKEGQ YEAACSKFSA TLQASGYQPD LSYNLALAYY SSRQYASALK HIAEIIERGI RQHPELGVGM TTEGFDVRSV GNTLVLHQTA LVEAFNLKAA IEYQLRNYEV AQETLTDMPP RAEEELDPVT LHNQALMNMD ARPTEGFEKL QFLLQQNPFP PETFGNLLLL YCKYEYFDLA ADV (1-342 aa encoded by BC042848)
靶标信息
The TTC30A gene encodes for the Tetratricopeptide Repeat Domain 30A, which is part of the intraflagellar transport (IFT) complex B, critical for ciliary function. TTC30A and its paralog TTC30B are involved in the stability and functioning of the IFT complex. These proteins play a redundant role in maintaining cilia integrity, necessary for proper cellular signaling and homeostasis. Disruption of TTC30A, through CRISPR/Cas9 gene editing, has shown to impair ciliogenesis, leading to developmental defects such as limb malformations and polycystic kidney disease due to altered tubulin acetylation and ciliary transport. This highlights the importance of TTC30A in cellular and developmental processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Intraflagellar transport protein 70A; tetratricopeptide repeat domain 30B; Tetratricopeptide repeat protein 30A; TPR repeat protein 30A
基因别名: IFT70A; TTC30A
UniProt ID: (Human) Q86WT1
Entrez Gene ID: (Human) 92104, (Rat) 100362431
