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Proteintech
WNK4 Polyclonal Antibody
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产品信息
22326-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
WNK4 Fusion Protein Ag17773 (845-1243 aa encoded by BC136664)
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: PISSQVSSN PSPHPTSSPL PFSSSTPEFP VPLSQCPWSS LPTTSPPTFS PTCSQVTLSS PFFPPCPSTS SFPSTTAAPL LSLASAFSLA VMTVAQSLLS PSPGLLSQSP PAPPSPLPSL PLPPPVAPGG QESPSPHTAE VESEASPPPA RPLPGEARLA PISEEGKPQL VGRFQVTSSK EPAEPLPLQP TSPTLSGSPK PSTPQLTSES SDTEDSAGGG PETREALAES DRAAEGLGAG VEEEGDDGKE PQVGGSPQPL SHPSPVWMNY SYSSLCLSSE ESESSGEDEE FWAELQSLRQ KHLSEVETLQ TLQKKEIEDL YSRLGKQPPP GIVAPAAMLS SRQRRLSKGS FPTSRRNSLQ RSEPPGPGIM RRNSLSGSST GSQEQRASKG VTFAGDVGRM (845-1243 aa encoded by BC136664)
靶标信息
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; protein kinase, lysine deficient 4; RP23-281C18.8; Serine/threonine-protein kinase WNK4
基因别名: 2010002J11Rik; PHA2B; PRKWNK4; WNK4
UniProt ID: (Human) Q96J92, (Mouse) Q80UE6
Entrez Gene ID: (Human) 65266, (Mouse) 69847
protein phosphorylation
ion transport
chloride transport
protein localization
positive regulation of ion transmembrane transporter activity
intracellular signal transduction
regulation of cellular process
ion homeostasis
renal sodium ion absorption
distal tubule morphogenesis
negative regulation of pancreatic juice secretion
regulation of ion homeostasis
phosphorylation
cellular chloride ion homeostasis
