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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: TSKPPIYLQH QGHSRTVIGI EEKKNRTLCL LILDPGCPSR EMQKLLKQDI EASSLKQLRK SMGNLKHKQY QILAVEGALS LEEKLARRQA SQVFTA
Antigen sequence identity: Mouse 89%; Rat 84%
Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: lys-63-specific deubiquitinase ZUFSP; ubiquitin carboxyl-terminal hydrolase ZUFSP; unnamed protein product; zinc finger with UFM1-specific peptidase domain protein
基因别名: C6orf113; DUB; ZUFSP
UniProt ID: (Human) Q96AP4
Entrez Gene ID: (Human) 221302