Invitrogen

beta Amyloid (1-40) Polyclonal Antibody

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2个已发表图片
11 篇参考文献
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说明书
实验方案
问题与答案
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beta Amyloid (1-40) Polyclonal Antibody

产品信息

44-348A

应用
建议稀释比
已发表文章

免疫组化 (IHC)

Assay-dependent
查看6篇已发表文章 6篇已发表文章

免疫组化（石蜡） (IHC (P))

-
查看3篇已发表文章 3篇已发表文章

免疫组化（冰冻） (IHC (F))

-
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent
查看1篇已发表文章 1篇已发表文章

酶联免疫吸附实验 (ELISA)

1 µg/mL
-

放射免疫测定 (RIA)

Assay-dependent
-

点杂交 (DB)

Assay-dependent
-
产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

The antibody was produced using a synthetic peptide derived from amino acids 34-40 within the C-terminal region of human beta-Amyloid protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.3

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533639

产品详细信息

This antibody reacts with human beta Amyloid (1-40). No significant cross-reactivity to beta Amyloid (1-42) has been observed. Previous lots have shown no cross-reactivity against beta Amyloid (1-43).

The antibody has been used in ELISA. Previous lots of this antibody have been used in dot blots, RIA, and other related assays.

靶标信息

Beta-amyloid is a 40-43 amino acid peptide cleaved from amyloid precursor protein, and a putative gamma-secretase. Amyloid beta (1-40) together with Amyloid beta (1-42) are two major C-terminal variants of the amyloid beta protein, constituting the majority of amyloid beta proteins. Both the amyloid beta (40) and amyloid beta (42) alloforms are major components of the extracellular plaques found in Alzheimer's disease brain tissue.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: A beta 1 40; A β 1 40; AB40; ABPP; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; Amyloid beta 1 40; Amyloid precursor protein; Amyloid β; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; APP; APPI; Aβ 1 40; B APP40; BAPP40; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; BetaAPP40; Cerebral vascular amyloid peptide; CVAP; peptidase nexin-II; PN-II; PreA4; Protease nexin-II; testicular tissue protein Li 2; β APP40; βAPP40

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基因别名: A4; AAA; ABETA; ABPP; AD1; APP; APPI; CTFgamma; CVAP; PN-II; PN2

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UniProt ID: (Human) P05067

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Entrez Gene ID: (Human) 351

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功能
DNA binding serine-type endopeptidase inhibitor activity receptor binding protein binding heparin binding peptidase activator activity enzyme binding identical protein binding transition metal ion binding PTB domain binding growth factor receptor binding protease inhibitor
参与通路
response to yeast suckling behavior platelet degranulation mRNA polyadenylation regulation of translation protein phosphorylation cellular copper ion homeostasis endocytosis response to oxidative stress cell adhesion regulation of epidermal growth factor-activated receptor activity Notch signaling pathway axonogenesis mating behavior locomotory behavior axo-dendritic transport cholesterol metabolic process adult locomotory behavior visual learning cellular process response to lead ion negative regulation of endopeptidase activity positive regulation of peptidase activity positive regulation of G2/M transition of mitotic cell cycle axon midline choice point recognition neuron remodeling dendrite development antibacterial humoral response antifungal humoral response extracellular matrix organization forebrain development neuron projection development ionotropic glutamate receptor signaling pathway regulation of multicellular organism growth regulation of protein binding cellular protein metabolic process innate immune response negative regulation of neuron differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter collateral sprouting in absence of injury regulation of synapse structure or activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium neuromuscular process controlling balance synaptic growth at neuromuscular junction neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis cellular response to cAMP cellular response to norepinephrine stimulus amyloid fibril formation cellular response to nerve growth factor stimulus
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