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Immunogen sequence: METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE GLQLPSPTAT SQLPLESDAV ECLNYQHYKG SDFDCELRLL IHQSLAGGII GVKGAKIKEL RENTQTTIKL FQECCPHSTD RVVLIGGKPD RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT MMFDDRRGRP VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY; Positive Samples: HeLa, Jurkat, 293T, MCF-7, HepG2, PC-12, Mouse testis; Cellular Location: Cell projection, Cytoplasm, Nucleus, nucleoplasm, podosome
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CSBP; dC stretch-binding protein; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; RP11-575L7.1; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP
基因别名: AUKS; CSBP; HNRNPK; HNRPK; KBBP; NOVA; TUNP
UniProt ID: (Human) P61978, (Rat) P61980, (Mouse) P61979
Entrez Gene ID: (Human) 3190, (Rat) 117282, (Mouse) 15387