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Human IL-1 F6 quantitates human IL-1 F6 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-1 F6.
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1E, IL1F6, IL36A
基因ID : (Human) 27179
基因符号 : IL36A
蛋白别名 : FIL1 epsilon, IL-1 epsilon, IL-1F6, IL-1F6 (FIL-1-epsilon), interleukin 1 family, member 6 (epsilon), interleukin 1, epsilon, Interleukin-1 epsilon, Interleukin-1 family member 6, Interleukin-36 alpha
UniProt ID (Human) Q9UHA7