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Mouse Leptin R quantitates mouse Leptin R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Leptin R.
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : Db, diabetes, Lepr, Leprb, LEPROT, Modb1, OB-RGRP, obese-like, obl, Obr
基因ID : (Mouse) 16847
基因符号 : Lepr
蛋白别名 : B219, CD295, LEP-R, Leptin receptor, leptin receptor gene-related protein, OB receptor, OB-R
UniProt ID (Mouse) Q61215