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Rabbit MIP-1beta quantitates rabbit MIP-1beta in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rabbit MIP-1beta.
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : ACT2, CCL4, SCYA4
基因ID : (Rabbit) 100008984
基因符号 : CCL4
蛋白别名 : ACT-2, C-C motif chemokine 4, immune activation gene 2, Immune activation protein 2, Macrophage inflammatory protein 1-beta, MIP-1-beta, Small-inducible cytokine A4
UniProt ID (Rabbit) P46632