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View our on-demand webinars below.

 

Bringing tomography to cell biology via the National Network of Cryo-ET Centers

40:00

In this webinar, we will highlight the significance of tomography for cell biology and provide an introduction to the National Network of Cyro-Electron Tomography Centers. The mission of this network is to deploy these capabilities in support of original research efforts and to train new users in cryo-tomography.

A journey from 2D to 3D of cells and tissues using electron microscopy

37:00

Modern electron microscope technology has made it possible to meet a broader range of imaging needs, from conventional 2D surface imaging to large, high-resolution 3D volume imaging of cells and tissues. Here we will discuss how Thermo Scientific scanning and transmission electron microscopes enable researchers to explore the architecture of the cellular world.

Enterovirus membrane-assisted assembly and release revealed by cryo-electron tomography webinar

50:48

Discuss how the polivirus reshapes the membranes of infected cells during replication Visualize how virions assemble directly on replication membranes Reveal with in situ cryo-electron tomography the interplay between polivirus and cellular autophagy.

Towards a mechanistic understanding of motile and primary cilia with CLEM and cryo-electron tomography and expansion microscopy

1:12:04

Gaia Pigino will show how the power of modern electron microscopy (EM) techniques, coupled with light microscopy and expansion methods, can open a window to the molecular dynamics of cells, enabling us to discover details about cellular processes at unprecedented level of detail.

Turn on the lights in cryo-FIB tomography sample preparation

58:22

Dr. Alex Rigort, Thermo Fisher Scientific, introduces the Thermo Fisher Scientific iFLM Correlative System to the Aquilos 2 cryo-FIB, which facilitates correlative imaging and lamella targeting all in one system for cryo-tomography lamellae preparation.

Molecular Architecture of SARS-CoV-2 virus

1:03:54

As featured in the October 2020 New York Times cover article, Dr. Sai Li of Tsinghua University presents the molecular assembly of the authentic SARS-CoV-2 virus using cryo-electron tomography (cryo-ET) and subtomogram averaging (STA) to producing the most detailed view of the virus structure.

Journey to the center of the cell with cryo-electron tomography

1:00:28

Dr. Philipp Erdmann, Max Planck Inst-Biochemistry Learn how cellular cryo-ET images intact cells in native state & high resolution, allowing quantitative analysis of cellular constituents & modelling of dynamic processes.

Cellular cryotomography unravels a missing link in coronavirus replication

23:53

Dr. Montserrat Barcena, Assistant Professor, Leiden University Medical Center (LUMC), gives a presentation at Thermo Fisher Scientific's Science Against SARS-CoV-2 Virtual Conference.

Cryo-electron tomography for cell biology

34:03

Prof. Ben Engel, Hemholz Zentrum Muchen, formerly MPI, Cryo-electron tomography allows you to visualize macromolecular structures in situ, inside the cell.

Aquilos 2 Cryo-FIB – state-of-the-art tomography sample preparation for in situ structural biology

1:08:32

Dr. Alex Rigort, Thermo Fisher Scientific Learn how cryo-FIB/SEM technology produces lamellas from frozen-hydrated cells -- enabling structural investigations of biomolecules in the context of cellular structures, preserved in near-native state.

Cryo-electron tomography contributes to our understanding of bacterial interactions with their environment

45:01

Prof. Ariane Briegel, NeCEN, Leiden University Learn how cryo-electron tomography can help understand the macromolecular machines bacteria use to sense and interact with their environment.

Unraveling the structure of toxic protein aggregates in situ by cryo-electron microscopy

19:50

Dr. Rubén Fernández-Busnadiego, MPI Biochemistry Learn how cryo-electron tomography imaging of protein aggregates within cells illuminates their mechanisms of cytotoxicity.

Untangling neurodegenerative diseases using cryo-electron microscopy

59:46

Prof. Anthony Fitzpatrick, Columbia University Cryo-EM solves structures of amyloid fibrils from patient post-mortem brain tissue with a range of neurological disorders & elucidates the molecular/structural basis of neurodegeneration.

What's new in Cryo-Tomography for cell biology?

42:49

Dr. Alex Rigort, Thermo Fisher Scientific Recorded May 2020, webinar highlights recent publications in cell biology & neuroscience from Nature, Science using cryo-tomography--enabling an unprecedented look at protein function within cellular context.

Advances in studying cellular biology – automated sample preparation for cryo-electron tomography

50:47

In this webinar, Dr. Sebastian Tacke, Max Planck Institute of Molecular Physiology, Dortmund, Germany, presents a strategy to reduce the risk of contamination and shares his experience with the recently introduced software package AutoTEM cryo, which enables automated cryo-FIB milling on the Aquilos.



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