将冷冻电镜技术带给您

无论您是经验丰富的显微镜专家,还是刚刚起步,Thermo Scientific Tundra 冷冻透射电子显微镜(冷冻透射电镜)都是一种精心为您设计的结构分析解决方案,旨在以合理的价格为您的实验室带来冷冻电镜。简化的数据收集和快速的样品上下样使 Tundra Cryo-TEM 成为解决您最具挑战性的研究问题的强大工具。使用 Tundra Cryo-TEM,您在校内就可获得具有一定生物学意义的分辨率的结构以解释您的生物学问题,或可靠地制备及筛选高质量样品,以便在 Thermo Scientific Krios 或 Glacios Cryo-TEM 上进行进一步分析。
 

Molecular structures determined using the Tundra Cryo-TEM

 

 

Tundra Cryo-TEM key benefits

Cryo-TEM sample preparation and optimization

The Tundra Cryo-TEM can visualize the impact of biochemical adjustments to samples faster than other technologies. Exchange samples in and out of the microscope in minutes, with nearly instantaneous feedback, allowing you to optimize your sample conditions quickly without extensive training.

Cryo-EM structures at biologically relevant resolution

The optics of the Tundra Cryo-TEM are specifically designed so that you can answer fundamental questions on biology and human disease with data at biologically relevant resolutions. Operating at 100 kV, the Tundra Cryo-TEM can generate high-contrast biological images down to 3.5 Å at medium throughput with its high-performance, fraction-enabled Thermo Scientific Ceta Camera.

Meet your budget

Meet your budget

A wide range of funding proposals and grants were considered when designing the Tundra Cryo-TEM to keep its price within the reach of most instrumentation grants. Our Electron Microscopy Funding Support Center has additional information about our financial services as well as grant-writing guidance so you can get the tools you need, when you need them.

Artificial intelligence takes the guesswork out of cryo-TEM

Artificial intelligence takes the guesswork out of cryo-TEM

The Tundra Cryo-TEM comes with a complete suite of automation software for efficient optimization of your sample’s biochemistry as well as data collection for structural determination. This includes a user-friendly AI-enabled software solution capable of analyzing intermediate results, providing instant feedback, and steering data collection on the fly. Our AI algorithms are based on years of cryo-EM knowledge, providing expert decisions upfront to ensure that your instrument is working at optimal conditions. Focus on the science rather than on fine-tuning the microscope.

 

Cryo-TEM webinar

Learn more about the Tundra Cryo-TEM in this 30 minute on-demand webinar, including:

  • How to make impactful structural biology discoveries with the Tundra Cryo-TEM.
  • Easier sample loading and retrieval with our novel, semi-automated loading system.
  • And more ...

Register to watch

Tundra Cryo-TEM 如何为您提供帮助?

Tundra Cryo-TEM 的易用性功能和引导式自动化功能使您可以轻松开始使用冷冻电镜,并且其价格点位于许多基金和资金来源的可及范围内。

Tundra Cryo-TEM 提供高效的载网筛选和优化。培训新的团队成员使用冷冻电镜的同时,不会浪费Glacios 或 Krios Cryo-TEM 的宝贵时间。

Tundra Cryo-TEM 使您能够将冷冻电镜带到您的组织机构;不需要最高分辨率数据的课题不会因为等待高需求的仪器而停滞。当需要异地分析时,您还可以制备尽可能最好的样品,因为 Tundra Cryo-TEM 使您能够快速评估载网的质量。

培训新的团队成员使用冷冻电镜的同时,不会浪费 Glacios 或 Krios Cryo-TEM 的宝贵时间。Tundra Cryo-TEM 还可用作快速样品筛选的专用显微镜。

Tundra Cryo-TEM 的易用性功能和引导式自动化功能使您可以轻松开始使用冷冻电镜,并且其价格点位于许多基金和资金来源的可及范围内。

Tundra Cryo-TEM 提供高效的载网筛选和优化。培训新的团队成员使用冷冻电镜的同时,不会浪费Glacios 或 Krios Cryo-TEM 的宝贵时间。

Tundra Cryo-TEM 使您能够将冷冻电镜带到您的组织机构;不需要最高分辨率数据的课题不会因为等待高需求的仪器而停滞。当需要异地分析时,您还可以制备尽可能最好的样品,因为 Tundra Cryo-TEM 使您能够快速评估载网的质量。

培训新的团队成员使用冷冻电镜的同时,不会浪费 Glacios 或 Krios Cryo-TEM 的宝贵时间。Tundra Cryo-TEM 还可用作快速样品筛选的专用显微镜。

Tundra Cryo-TEM 的优势

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冷冻电镜资金帮助中心

冷冻电镜资金帮助中心

获得资金可能是一个要求严格、耗费时间且充满压力的过程。我们的冷冻电镜资助中心提供了方案撰写工具以及可以指导您完成整个过程的技术专家。

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Tundra Cryo-EM 服务和支持

Tundra Cryo-EM 服务和支持

我们的服务和支持选项可确保您最大限度地延长仪器的正常运行时间和提升数据质量。

 手册下载

Cryo-EM Ask the Experts Series

Cryo-EM Ask the Experts Series

Watch and engage with cryo-electron microscopy researchers while they discuss the practical and theoretical aspects of their work.

Register now

性能数据

Tundra Cryo-TEM 的技术亮点

  • 24-72 小时内 3.5 Å 脱铁铁蛋白结构的测定
  • 高亮度X-FEG(极场发射枪)
  • 固定加速电压 100 kV
  • 半自动上样
  • 冷冻上样工作站可实现无污染样品更换
  • 用于将单个 AutoGrid 传输至显微镜的样品转移装置
    • 固定式Cryo-box可保持样品不受污染长达 72 小时
  • 电脑控制的样品冷冻样品台
  • 具有剂量分割功能的高性能 Thermo Scientific Ceta 相机,针对低剂量成像进行了优化
  • 用于自动单颗粒分析筛选和数据采集的 EPU 2 软件
  • Smart EPU 软件:一种支持 AI 的软件解决方案,可为数据收集提供反馈。包括一个开放的应用程序编程接口

相关资源

The Tundra Cryo-TEM is a dedicated structure-determination solution designed to bring single particle analysis to every biochemistry laboratory.

Dr. Jiri Novacek from CEITEC, Masaryk University, discusses how cryo-EM is accelerating his plant research, by understanding the structure and function of plum pox virus.

Dr. Jared Auclair, Director of Biopharmaceutical Analysis Laboratory, Northwestern University, talks about using the Tundra Cryo-TEM to gather data on molecules including batch-to-batch consistency. The automation, flexibility, and integration of cryo-EM is critical in biopharmaceutical laboratories.

Dr. James Whisstock, professor from Monash University, discusses how the Tundra Cryo-TEM can collect complete data sets at near atomic resolution in less than a few days for structural drug discovery.

Cryo-TEM webinar

Learn more about the Tundra Cryo-TEM in this 30 minute on-demand webinar, including:

  • How to make impactful structural biology discoveries with the Tundra Cryo-TEM.
  • Easier sample loading and retrieval with our novel, semi-automated loading system.
  • And more ...

Register to watch

The Tundra Cryo-TEM is a dedicated structure-determination solution designed to bring single particle analysis to every biochemistry laboratory.

Dr. Jiri Novacek from CEITEC, Masaryk University, discusses how cryo-EM is accelerating his plant research, by understanding the structure and function of plum pox virus.

Dr. Jared Auclair, Director of Biopharmaceutical Analysis Laboratory, Northwestern University, talks about using the Tundra Cryo-TEM to gather data on molecules including batch-to-batch consistency. The automation, flexibility, and integration of cryo-EM is critical in biopharmaceutical laboratories.

Dr. James Whisstock, professor from Monash University, discusses how the Tundra Cryo-TEM can collect complete data sets at near atomic resolution in less than a few days for structural drug discovery.

Cryo-TEM webinar

Learn more about the Tundra Cryo-TEM in this 30 minute on-demand webinar, including:

  • How to make impactful structural biology discoveries with the Tundra Cryo-TEM.
  • Easier sample loading and retrieval with our novel, semi-automated loading system.
  • And more ...

Register to watch

 

 

Smart EPU software for Cryo-TEM

User-friendly software for day-to-day operation

  • Microscope-embedded solution for single particle analysis and data acquisition
  • Reduced need for prior expertise: software assists with experimental set-up, providing real-time feedback
  • Optimized for high-throughput particle collection

The open API of Smart EPU Software allows you to develop your own functions for the Tundra Cryo-TEM.

应用

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使用冷冻电镜进行传染病研究

传染病研究

冷冻电镜技术可在近天然状态下对生物大分子的 3D 结构进行多尺度的观察,有助于提高治疗方法的开发速度和效率。

使用冷冻电镜进行结构生物学研究

结构生物学研究

借助冷冻电镜(Cryo-EM)对具有挑战性的生物靶标(例如大型复合物、柔性物质和膜蛋白)进行结构分析。

神经退行性病变研究

神经退行性疾病研究

冷冻电镜可以确定与神经退行性疾病有关的蛋白质聚集体的结构特性,从而使科学家们能够解决有关这类蛋白质聚集体如何形成、与细胞环境相互作用以及改变大脑功能的问题。

技术

单颗粒分析

单颗粒分析(SPA)是一种冷冻电镜技术,可实现近原子分辨率的结构表征,揭示动态生物学过程以及生物分子复合物/组装体的结构。

了解更多 ›

单颗粒分析

单颗粒分析(SPA)是一种冷冻电镜技术,可实现近原子分辨率的结构表征,揭示动态生物学过程以及生物分子复合物/组装体的结构。

了解更多 ›


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Style Sheet for Komodo Tabs
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用于将 H3 更改为具有 em-h3-header 类 p 的样式表
用于将应用程序 H3 更改为具有 em-h3-header 类 p 的样式表
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电子显微镜服务

为实现理想的系统性能,我们为您提供了由现场服务专家、技术支持部门和认证备件组成的全球网络支持。

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