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Translational Research Resources

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Unlock the full potential of your translational research with comprehensive resources and latest insights.

Biomarker discovery

Plasma profiling–reliable large cohort analysis with a fully automated workflow

Using automated workflows to process and analyze plasma large cohorts.

High-throughput plasma proteomics workflow on a Thermo Scientific Orbitrap Exploris 480 mass spectrometer

Scalable plasma proteomic workflows using Orbitrap Exploris 480 MS.

Unveiling hidden protein depths: a high-throughput plasma proteomics workflow for enhanced biomarker discovery

Scalable plasma proteomic workflows using Orbitrap Astral MS.

Unveil plasma proteomics with cutting-edge hybrid-DIA methods utilizing two strategies on the Orbitrap Astral Zoom MS

Discover hybrid-DIA methods that utilize two strategies to simultaneously
perform targeted peptide quantitation and DIA discovery proteomics.

Plasma proteomics: harnessing cutting-edge technologies for unprecedented depth and throughput

Experience unprecedented plasma proteomic depth with Seer Proteograph and Thermo technology.

Elevating plasma proteomics: high-throughput, quantitative analysis with automated MagNet workflow with Evosep One and the Orbitrap Astral mass spectrometer

The integration of the MagNet workflow with Evosep One and Orbitrap Astral MS significantly enhances throughput, sensitivity, and reproducibility in plasma proteomics, providing a powerful and efficient platform for large-scale studies and clinical research.

Uncovering biological differences at scale: High-throughput and in-depth plasma proteomics with the Seer Proteograph ONE workflow and Orbitrap Astral Zoom mass spectrometer

Enabling scalable, reproducible plasma proteomics with clear detection of biological differences for biomarker discovery applications.

Comprehensive and high-throughput plasma proteome profiling for biomarker discovery

Unlocking the full potential of plasma proteomics using the Orbitrap Astral Zoom Mass Spectrometer and the Seer Proteograph ONE Assay.

High-throughput plasma proteomics for translational biomarker discovery using PreOmics sample preparation and the Orbitrap Astral mass spectrometer

Discovering how PreOmics workflows combined with the Orbitrap Astral MS deliver deep, precise, and biologically meaningful plasma proteomics data ideal

Scalable and deep plasma proteomics on the Orbitrap Excedion Pro mass spectrometer

Plasma proteomics workflows on Orbitrap Excedion Pro MS and OptiSpray Ion Source.

Biomarker verification

Breaking barriers: Practical approaches to translating proteins from biomarker candidates to verified biomarkers

Discover how Stellar mass spectrometer significantly enhances biomarker discovery and verification.

Breaking barriers for biomarker translation toward validation: Creating a new verification-class mass spectrometer with the Stellar Mass Spectrometer

How the Stellar Mass Spectrometer breaks barriers for biomarker verification.

Democratizing proteomics: Highly multiplex targeted analysis of biofluids

Large plasma protein panel PRM targeted proteomics with Stellar Mass Spectrometer.

Transitioning biomarkers from discovery to validation at unprecedented scale with the Stellar Mass Spectrometer

Exploring technological advancements and capabilities of Stellar Mass Spectrometer.

Global plasma proteome quantification using internal standard triggered targeted analyses

Plasma proteome analysis using SureQuant on Orbitrap instruments.

Translation of Proteograph XT nanoparticle-enriched plasma proteomics features to a targeted assay

Verification of cancer plasma biomarker candidates generated from Seer Proteograph XT Assay technology.

New paradigm for plasma proteomics biomarker research

Large-scale targeted PRM proteomics assays enabled by the Stellar mass spectrometer.

Unlocking biological insights with Stellar MS for adaptive RT-enhanced quantitative proteomics for plasma biomarker analysis

Discover how Stellar mass spectrometer enables large-scale, highly multiplexed targeted proteomics.

How Monash University is expanding what’s possible in proteomics with Orbitrap Astral MS

Learn how Monash University is combining high-throughput performance with reproducible, in-depth analysis to achieve deeper biological insight in discovery-focused research.

Absolute quantification of plasma proteins using recombinant protein standards and high-throughput targeted mass spectrometry

ProteomEdge qRePS with Stellar MS enables scalable, reproducible absolute quantification in plasma proteomics.

Discover key insights: Translational research FAQs

Translational Research applies scientific discoveries to improve human health by developing new diagnostic tools, treatments, and interventions that benefit patients and ultimately improve patient outcomes.

Biomarkers are measurable indicators used in medicine, research, and drug development to assess diseases, monitor treatment effectiveness, and identify therapeutic targets. They can provide valuable insights into complex biological processes, inform decisions and drive advancements in healthcare.

The discovery and validation of biomarkers present challenges due to the complexity of biological systems, the requirement for rigorous scientific investigation, and adherence to regulatory standards. Additionally, the variability within patient populations and the iterative nature of biomarker development poses a challenge.

Proteins serve as biomarkers by capturing the effects of genetic variations, environmental factors, and lifestyle influences, offering real-time information on disease progression and treatment response. Unlike genetic tests or imaging results, proteins reflect the dynamic nature of disease-associated alterations, serving as functional molecules in biological systems.

Our advanced mass spectrometry solutions empower studies with precise protein identification, quantitation, and analysis. Together, we can revolutionize science, uncover disease mechanisms, and discover biomarkers. With our trusted expertise, accelerate breakthroughs and make a profound impact to experience the future of proteomics today.

Biofluids and tissues are used in translational research because they provide critical, real-time insights into the physiological and pathological states of an organism, enabling the identification and validation of biomarkers for disease diagnosis, prognosis, and therapeutic response.

Our general purpose product lines, including LC-MS products, are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

 

Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks. They are designated for Research Use Only Applications.

 

For Research Use Only - Not For Use In Diagnostic Procedures.

General Laboratory Equipment – Not For Diagnostic Procedures. © 2026 Thermo Fisher Scientific Inc. All rights reserved. Thermo Scientific™ products are designated as General Laboratory Equipment and are not intended for use in diagnostic procedures or for in vitro diagnostic purposes. These products are intended for general laboratory use only and have not been tested or validated for diagnostic applications; use for such purposes may result in inaccurate results and may pose health and safety risks. They are designed for research, academic, and industrial applications and for general-purpose analytical use, including high-resolution and accurate-mass measurements, without reference to specific clinical conditions, analytes, or diagnostic decisions.

The Thermo Scientific Orbitrap Exploris and Excedion series mass spectrometers are Orbitrap instruments with an atmospheric pressure ionization (API) source for liquid chromatography (LC) mass spectrometry (MS) high-throughput applications. The instruments are designed to be placed on a bench in the laboratory and maintain mass accuracy across chromatographic peaks, supporting confident identification and quantitation using high-resolution accurate-mass detection.