Translational Research Resources

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Biomarker discovery

Plasma profiling–reliable large cohort analysis with a fully automated workflow

Using automated workflows to process and analyze plasma large cohorts.

High-throughput plasma proteomics workflow on a Thermo Scientific Orbitrap Exploris 480 mass spectrometer

Scalable plasma proteomic workflows using Orbitrap Exploris 480 MS.

Unveiling hidden protein depths: a high-throughput plasma proteomics workflow for enhanced biomarker discovery

Scalable plasma proteomic workflows using Orbitrap Astral MS.

Combining data- and hypothesis-driven approaches in one go via a novel Intelligent data acquisition hybrid-DIA mass spectrometry strategy

Leveraging Hybrid-DIA for advanced detection of target peptides during discovery data acquisition.

Plasma proteomics: harnessing cutting-edge technologies for unprecedented depth and throughput

Experience unprecedented plasma proteomic depth with Seer Proteograph and Thermo technology.

Elevating plasma proteomics: high-throughput, quantitative analysis with automated MagNet workflow with Evosep One and the Orbitrap Astral mass spectrometer

The integration of the MagNet workflow with Evosep One and Orbitrap Astral MS significantly enhances throughput, sensitivity, and reproducibility in plasma proteomics, providing a powerful and efficient platform for large-scale studies and clinical research.

Uncovering biological differences at scale: High-throughput and in-depth plasma proteomics with the Seer Proteograph ONE workflow and Orbitrap Astral Zoom mass spectrometer

Enabling scalable, reproducible plasma proteomics with clear detection of biological differences for biomarker discovery applications.

Comprehensive and high-throughput plasma proteome profiling for biomarker discovery

Unlocking the full potential of plasma proteomics using the Orbitrap Astral Zoom Mass Spectrometer and the Seer Proteograph ONE Assay.

Biomarker verification

Breaking barriers for biomarker translation toward validation: Creating a new verification-class mass spectrometer with the Stellar Mass Spectrometer

How the Stellar Mass Spectrometer breaks barriers for biomarker verification.

Democratizing proteomics: Highly multiplex targeted analysis of biofluids

Large plasma protein panel PRM targeted proteomics with Stellar Mass Spectrometer.

Transitioning biomarkers from discovery to validation at unprecedented scale with the Stellar Mass Spectrometer

Exploring technological advancements and capabilities of Stellar Mass Spectrometer.

Global plasma proteome quantification using internal standard triggered targeted analyses

Plasma proteome analysis using SureQuant on Orbitrap instruments.

Translation of Proteograph XT nanoparticle-enriched plasma proteomics features to a targeted assay

Verification of cancer plasma biomarker candidates generated from Seer Proteograph XT Assay technology.

New paradigm for plasma proteomics biomarker research

Large-scale targeted PRM proteomics assays enabled by the Stellar mass spectrometer.

Discover key insights: Translational research FAQs

Translational Research applies scientific discoveries to improve human health by developing new diagnostic tools, treatments, and interventions that benefit patients and ultimately improve patient outcomes.

Biomarkers are measurable indicators used in medicine, research, and drug development to assess diseases, monitor treatment effectiveness, and identify therapeutic targets. They can provide valuable insights into complex biological processes, inform decisions and drive advancements in healthcare.

The discovery and validation of biomarkers present challenges due to the complexity of biological systems, the requirement for rigorous scientific investigation, and adherence to regulatory standards. Additionally, the variability within patient populations and the iterative nature of biomarker development poses a challenge.

Proteins serve as biomarkers by capturing the effects of genetic variations, environmental factors, and lifestyle influences, offering real-time information on disease progression and treatment response. Unlike genetic tests or imaging results, proteins reflect the dynamic nature of disease-associated alterations, serving as functional molecules in biological systems.

Our advanced mass spectrometry solutions empower studies with precise protein identification, quantitation, and analysis. Together, we can revolutionize science, uncover disease mechanisms, and discover biomarkers. With our trusted expertise, accelerate breakthroughs and make a profound impact to experience the future of proteomics today.

Biofluids and tissues are used in translational research because they provide critical, real-time insights into the physiological and pathological states of an organism, enabling the identification and validation of biomarkers for disease diagnosis, prognosis, and therapeutic response.

For Research Use Only. Not for use in diagnostic procedures.