Gibco CTS Dynabeads T Cell Expansion Products

The first step in manufacturing an immunotherapy – autologous or allogeneic – is to collect peripheral blood mononuclear cells (PBMCs) from a patient (or donor for allogeneic). The cells then need to be isolated from the other mononuclear cells. Gibco CTS Dynabeads magnetic beads are a trusted technology for the isolation, activation, and/or expansion of T cells ex vivo. Whether working with polyclonal T cells, antigen-specific T cells, gene-modified T cells, regulatory T cells, or other T cell subtypes, CTS Dynabeads magnetic beads enable the recovery of T cells with properties comparable to in vivo–activated T cells. Select the correct Dynabeads magnetic beads for your specific work. 

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Gibco CTS Dynabeads T cell expansion product features:

  • Suitable for the isolation, activation, and/or expansion of polyclonal T cells, antigen-specific T cells, gene-modified T cells, and other T cell subtypes
  • Isolated and activated T cells help enable efficient gene transduction
  • Expanded T cells have a T central memory phenotype with in vivo persistence
  • Help deliver 100- to 1,000-fold expansion in 9–14 days

CTS Dynabeads CD3/CD28*

  • CTS Dynabeads CD3/CD28 isolate CD3+ CD28+ T cells  to high purity with high efficiency
  • Isolated and activated CD4+ and CD8⁺ T cells expand 100- to 800-fold in 10 days while retaining a young phenotype (CD45RA+/– CD127+/– CD62L⁺   PD-1–)
  • Expanded T cells have increased clonal diversity based on TCRβ sequencing 
  • Bead removal on day 2 improves transduction efficiency of a γ-retrovirus
  • cGMP-compliant

CTS Dynabeads Treg Xpander*

  • Aseptically manufactured and ready for clinical trials and cell therapy manufacturing process development 
  • Drug Master File (DMF) to cross-reference in IND applications
  • >800-fold expansion after two stimulations 
  • Treg phenotype (FOXP3) and suppressive function maintained
  • cGMP-compliant

Dynabeads Human T-Activator CD3/CD28*

  • Activation of T cells without the need for feeder cells
  • Activated cells that retain in vivo-like function
  • Maximum reproducibility without contamination by soluble antibodies or mitogens
  • From 100- to 1,000-fold T cell expansion
In addition, camelid-derived, single-domain (VHH) antibody fragments with binding specificity for human CD3 receptors and human CD28 receptors are available by request to Thermo Fisher Scientific.  Please submit requests for samples to captureselectsupport@thermofisher.com
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