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Empower lead optimization with comprehensive SelectScreen profiling services designed to provide the critical data needed at every stage of compound refinement. By integrating validated biochemical and cell-based assays with kinase profiling, cell-based profiling, and hERG safety screening, we deliver reliable, high-quality data that enables informed decision-making, streamlines structure–activity relationship (SAR) studies, improves compound selectivity, and helps identify the strongest candidates for continued development. Supported by dedicated project management and experienced scientific experts, we work as an extension of your team to keep discovery programs moving forward.
SelectScreen Lead Optimization Services offer drug discovery researchers a faster method for narrowing the selection of drug candidates for downstream selectivity profiling and further investigation. The assays we perform can be target-based, investigating changes to function, or phenotypic, examining the biologic response that a compound has on cells.
Steamline your process for identifying your most promising drug compounds and enable your medicinal chemists to receive data faster with our cost-effective lead optimization services.
Our in-house team can run biochemical and cellular assays to optimize drug potency and generate dose-response curves, identifying the compounds that cause the desired effect in your target of interest. Choose from our broad portfolio of assay technologies*, or provide your own targets/assays and we can perform validation.
*We can also perform validation and screening of client-provided assays that do not utilize our technologies to fit your specific screening needs. If you would like to request a technology outside of the Thermo Fisher Scientific portfolio, please send us an inquiry.
Lead optimization services offer an advantage over broader screening because we can deliver data quickly, typically in 3 to 5 days (depending on the assay), and at lower cost than large panel screens. This enables you to make chemistry decisions more rapidly and move leads forward.
Example
|
Broad profiling |
Lead optimization |
|---|---|---|
Number of targets/assays |
Many |
Few |
Mode |
Single point with dose-response curve follow-up |
Dose-response curves |
Submission schedule |
On demand |
Weekly schedule |
Client commitment |
On demand |
6+ months |
Turnaround time |
Avg. 4 to 8 days |
Avg. 2 to 5 days |
Cost |
$$ |
$ |
After leads are optimized, top drug candidates can be carried forward for selectivity profiling to determine specificity and downstream impact in preparation for possible future clinical testing.
Personalized support is at the core of every SelectScreen project. From project initiation through data delivery, you'll work with a dedicated project manager who serves as your single point of contact, providing proactive communication, coordinating timelines and milestones, and ensuring proficient project execution.
Backed by experienced scientists and technical specialists, our team works as an extension of yours to deliver a responsive, collaborative experience and high-quality results tailored to your research goals.
For Research Use Only. Not for use in diagnostic procedures.