This peptide corresponds to 17 amino acid peptide near the amino terminus of human AGR2.
PEP-1560 can be used as a blocking peptide with polyclonal antibody PA5-34517. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37°C.
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
蛋白别名: AG-2; anterior gradient homolog 2; Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog
基因别名: AG2; AGR2; GOB-4; HAG-2; HEL-S-116; PDIA17; UNQ515/PRO1030; XAG-2
UniProt ID: (Human) O95994
Entrez Gene ID: (Human) 10551