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产品信息
PEP-0438
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Dry ice
产品详细信息
This peptide corresponds to 18 amino acids near the center of human APH1
PEP-0438 can be used as a blocking peptide with polyclonal antibody PA5-20318.
靶标信息
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: anterior pharynx defective 1 homolog A; aph-1 homolog A, gamma secretase subunit; APH-1a; Aph-1alpha; APH1A gamma secretase subunit; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; RP4-790G17.3
基因别名: 6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3
Entrez Gene ID: (Human) 51107
