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产品信息
PEP-0749
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Dry ice
产品详细信息
This peptide corresponds to 12 amino acids near the amino terminus of human Dact2.
PEP-0749 can be used as a blocking peptide with polyclonal antibody PA5-20629.
靶标信息
The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
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生物信息学
蛋白别名: Dapper antagonist of catenin 2; Dapper homolog 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2; dishevelled-binding antagonist of beta-catenin 2; RP11-503C24.7
基因别名: bA503C24.7; C6orf116; DACT2; DAPPER2; DPR2; PP13671
UniProt ID: (Human) Q5SW24
Entrez Gene ID: (Human) 168002
