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产品信息
PV4716
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
168-448
标签
GST-tag
分类
Recombinant
类型
Protein
偶联物
Unconjugated
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
Retinoic acid receptor beta, ligand binding domain (RARB-LBD) is a 59.20 kDa recombinant human protein (amino acids 168-448) expressed as a GST-tagged fusion protein in baculovirus-infected insect cells. RARB-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Protein Form: Ligand Binding Domain
靶标信息
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide
基因别名: HAP; MCOPS12; NR1B2; RARB; RARbeta1; RRB2
UniProt ID: (Human) P10826
Entrez Gene ID: (Human) 5915
