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产品信息
PEP-0874
产品规格
种属反应
Human
宿主/亚型
Artificial Control
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 16 amino acids near the center of human RGS21.
PEP-0874 can be used as a blocking peptide with polyclonal antibody PA5-20760.
靶标信息
Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.
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生物信息学
蛋白别名: Regulator of G-protein signaling 21; regulator of G-protein signalling 21; RGS21
基因别名: RGS21
UniProt ID: (Human) Q2M5E4
Entrez Gene ID: (Human) 431704
