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This peptide corresponds to 16 amino acids near the center of human TEM7.
PEP-0545 can be used as a blocking peptide with polyclonal antibody PA5-20428.
Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2410003I07Rik; DKFZp686F0937; FLJ36270; FLJ45632; Plexin domain-containing protein 1; Tumor endothelial marker 3; Tumor endothelial marker 7
基因别名: PLXDC1; TEM3; TEM7
UniProt ID: (Human) Q8IUK5
Entrez Gene ID: (Human) 57125