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Gibco
Human TGF-beta 3 Recombinant Protein
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产品信息
PHG9302
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
Human TGF-beta 3 recombinant protein is a homodimer containing two 112 amino acid subunits
分子量
25.4 kDa
分类
Recombinant
类型
Protein
纯度
>98% by SDS-PAGE and HPLC
内毒素浓度
<0.1 ng/µg
活性
ED50 ≤ 0.05 ng/mL (≥ 12.5x10e6 IU/mg); determined by a toxicity assay using the WHO Standard 98/608 for direct comparison.
偶联物
形式
Liquid
纯化类型
purified
保存液
0.12% acetic acid with 20% ethanol
内含物
no preservative
保存条件
4°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
•Purity: >98% by SDS-PAGE and HPLC
•Endotoxin Concentration: <0.1 ng/µg
•Protein Length: 112 aa (2 identical subunits)
•Biological Activity: ED50 ≤0.05 ng/mL
•Molecular Weight: 17.5 kDa
靶标信息
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3
基因别名: ARVD; ARVD1; LDS5; RNHF; TGF-beta3; TGFB3
UniProt ID: (Human) P10600
Entrez Gene ID: (Human) 7043
