This peptide corresponds to 17 amino acids near the carboxy terminus of human VGF.
PEP-0643 can be used as a blocking peptide with polyclonal antibody PA5-20523.
VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.
蛋白别名: Antimicrobial peptide VGF[554-577]; NERP-1; NERP-2; neuro-endocrine specific protein VGF; Neuroendocrine regulatory peptide-1; Neuroendocrine regulatory peptide-2; Neurosecretory protein VGF; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62
基因别名: SCG7; SgVII; VGF
UniProt ID: (Human) O15240
Entrez Gene ID: (Human) 7425